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Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir.

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Title: Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir.
Authors: Prévost J; Centre de Recherche du CHUM, Montreal, QC, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada., Chen Y; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Zhou F; Unit on Structural Biology, Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA., Tolbert WD; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Gasser R; Centre de Recherche du CHUM, Montreal, QC, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada., Medjahed H; Centre de Recherche du CHUM, Montreal, QC, Canada., Nayrac M; Centre de Recherche du CHUM, Montreal, QC, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada., Nguyen DN; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Gottumukkala S; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Hessell AJ; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA., Rao VB; Department of Biology, the Catholic University of America, Washington, DC, USA., Pozharski E; Institute for Bioscience and Biotechnology Research, Rockville, MD, 20850, USA.; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA., Huang RK; Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, USA., Matthies D; Unit on Structural Biology, Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA., Finzi A; Centre de Recherche du CHUM, Montreal, QC, Canada. andres.finzi@umontreal.ca.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada. andres.finzi@umontreal.ca., Pazgier M; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. marzena.pazgier@usuhs.edu.
Source: Nature communications [Nat Commun] 2023 Oct 23; Vol. 14 (1), pp. 6710. Date of Electronic Publication: 2023 Oct 23.
Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir.
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  Data: <searchLink fieldCode="AU" term="%22Prévost+J%22">Prévost J</searchLink>; Centre de Recherche du CHUM, Montreal, QC, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+F%22">Zhou F</searchLink>; Unit on Structural Biology, Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Tolbert+WD%22">Tolbert WD</searchLink>; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Gasser+R%22">Gasser R</searchLink>; Centre de Recherche du CHUM, Montreal, QC, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Medjahed+H%22">Medjahed H</searchLink>; Centre de Recherche du CHUM, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Nayrac+M%22">Nayrac M</searchLink>; Centre de Recherche du CHUM, Montreal, QC, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Nguyen+DN%22">Nguyen DN</searchLink>; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Gottumukkala+S%22">Gottumukkala S</searchLink>; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Hessell+AJ%22">Hessell AJ</searchLink>; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA.<br /><searchLink fieldCode="AU" term="%22Rao+VB%22">Rao VB</searchLink>; Department of Biology, the Catholic University of America, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Pozharski+E%22">Pozharski E</searchLink>; Institute for Bioscience and Biotechnology Research, Rockville, MD, 20850, USA.; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Huang+RK%22">Huang RK</searchLink>; Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, USA.<br /><searchLink fieldCode="AU" term="%22Matthies+D%22">Matthies D</searchLink>; Unit on Structural Biology, Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Finzi+A%22">Finzi A</searchLink>; Centre de Recherche du CHUM, Montreal, QC, Canada. andres.finzi@umontreal.ca.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada. andres.finzi@umontreal.ca.<br /><searchLink fieldCode="AU" term="%22Pazgier+M%22">Pazgier M</searchLink>; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. marzena.pazgier@usuhs.edu.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2023 Oct 23; Vol. 14 (1), pp. 6710. <i>Date of Electronic Publication: </i>2023 Oct 23.
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