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N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity.

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Title: N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity.
Authors: Varland S; Department of Biomedicine, University of Bergen, N-5021, Bergen, Norway. sylvia.varland@gmail.com.; Department of Biological Sciences, University of Bergen, N-5006, Bergen, Norway. sylvia.varland@gmail.com.; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada. sylvia.varland@gmail.com., Silva RD; Algarve Biomedical Center Research Institute, Universidade do Algarve, 8005-139, Faro, Portugal. rfdsilva@gmail.com.; Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, 8005-139, Faro, Portugal. rfdsilva@gmail.com., Kjosås I; Department of Biomedicine, University of Bergen, N-5021, Bergen, Norway., Faustino A; Algarve Biomedical Center Research Institute, Universidade do Algarve, 8005-139, Faro, Portugal., Bogaert A; VIB-UGent Center for Medical Biotechnology, B-9052, Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, B-9052, Ghent, Belgium., Billmann M; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, Minneapolis, MN, 55455, USA.; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, D-53127, Bonn, Germany., Boukhatmi H; Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes 1, CNRS, UMR6290, 35065, Rennes, France., Kellen B; Algarve Biomedical Center Research Institute, Universidade do Algarve, 8005-139, Faro, Portugal., Costanzo M; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada., Drazic A; Department of Biomedicine, University of Bergen, N-5021, Bergen, Norway., Osberg C; Department of Biomedicine, University of Bergen, N-5021, Bergen, Norway., Chan K; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada., Zhang X; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, Minneapolis, MN, 55455, USA., Tong AHY; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada., Andreazza S; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0XY, UK., Lee JJ; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0XY, UK., Nedyalkova L; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada., Ušaj M; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada., Whitworth AJ; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0XY, UK., Andrews BJ; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 3E1, Canada., Moffat J; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 3E1, Canada.; Program in Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, M5G 1×8, Canada., Myers CL; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, Minneapolis, MN, 55455, USA.; Bioinformatics and Computational Biology Graduate Program, University of Minnesota-Twin Cities, Minneapolis, MN, 55455, USA., Gevaert K; VIB-UGent Center for Medical Biotechnology, B-9052, Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, B-9052, Ghent, Belgium., Boone C; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 3E1, Canada.; RIKEN Centre for Sustainable Resource Science, Wako, Saitama, 351-0106, Japan., Martinho RG; Algarve Biomedical Center Research Institute, Universidade do Algarve, 8005-139, Faro, Portugal. rgmartinho@ua.pt.; Departmento de Ciências Médicas, Universidade de Aveiro, 3810-193, Aveiro, Portugal. rgmartinho@ua.pt.; iBiMED - Institute of Biomedicine, Universidade de Aveiro, 3810-193, Aveiro, Portugal. rgmartinho@ua.pt., Arnesen T; Department of Biomedicine, University of Bergen, N-5021, Bergen, Norway. thomas.arnesen@uib.no.; Department of Biological Sciences, University of Bergen, N-5006, Bergen, Norway. thomas.arnesen@uib.no.; Department of Surgery, Haukeland University Hospital, N-5021, Bergen, Norway. thomas.arnesen@uib.no.
Source: Nature communications [Nat Commun] 2023 Oct 27; Vol. 14 (1), pp. 6774. Date of Electronic Publication: 2023 Oct 27.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity.
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  Data: <searchLink fieldCode="AU" term="%22Varland+S%22">Varland S</searchLink>; Department of Biomedicine, University of Bergen, N-5021, Bergen, Norway. sylvia.varland@gmail.com.; Department of Biological Sciences, University of Bergen, N-5006, Bergen, Norway. sylvia.varland@gmail.com.; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada. sylvia.varland@gmail.com.<br /><searchLink fieldCode="AU" term="%22Silva+RD%22">Silva RD</searchLink>; Algarve Biomedical Center Research Institute, Universidade do Algarve, 8005-139, Faro, Portugal. rfdsilva@gmail.com.; Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, 8005-139, Faro, Portugal. rfdsilva@gmail.com.<br /><searchLink fieldCode="AU" term="%22Kjosås+I%22">Kjosås I</searchLink>; Department of Biomedicine, University of Bergen, N-5021, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Faustino+A%22">Faustino A</searchLink>; Algarve Biomedical Center Research Institute, Universidade do Algarve, 8005-139, Faro, Portugal.<br /><searchLink fieldCode="AU" term="%22Bogaert+A%22">Bogaert A</searchLink>; VIB-UGent Center for Medical Biotechnology, B-9052, Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, B-9052, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Billmann+M%22">Billmann M</searchLink>; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, Minneapolis, MN, 55455, USA.; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, D-53127, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Boukhatmi+H%22">Boukhatmi H</searchLink>; Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes 1, CNRS, UMR6290, 35065, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Kellen+B%22">Kellen B</searchLink>; Algarve Biomedical Center Research Institute, Universidade do Algarve, 8005-139, Faro, Portugal.<br /><searchLink fieldCode="AU" term="%22Costanzo+M%22">Costanzo M</searchLink>; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.<br /><searchLink fieldCode="AU" term="%22Drazic+A%22">Drazic A</searchLink>; 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MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Nedyalkova+L%22">Nedyalkova L</searchLink>; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.<br /><searchLink fieldCode="AU" term="%22Ušaj+M%22">Ušaj M</searchLink>; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.<br /><searchLink fieldCode="AU" term="%22Whitworth+AJ%22">Whitworth AJ</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Andrews+BJ%22">Andrews BJ</searchLink>; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 3E1, Canada.<br /><searchLink fieldCode="AU" term="%22Moffat+J%22">Moffat J</searchLink>; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 3E1, Canada.; Program in Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, M5G 1×8, Canada.<br /><searchLink fieldCode="AU" term="%22Myers+CL%22">Myers CL</searchLink>; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, Minneapolis, MN, 55455, USA.; Bioinformatics and Computational Biology Graduate Program, University of Minnesota-Twin Cities, Minneapolis, MN, 55455, USA.<br /><searchLink fieldCode="AU" term="%22Gevaert+K%22">Gevaert K</searchLink>; VIB-UGent Center for Medical Biotechnology, B-9052, Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, B-9052, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Boone+C%22">Boone C</searchLink>; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 3E1, Canada.; RIKEN Centre for Sustainable Resource Science, Wako, Saitama, 351-0106, Japan.<br /><searchLink fieldCode="AU" term="%22Martinho+RG%22">Martinho RG</searchLink>; Algarve Biomedical Center Research Institute, Universidade do Algarve, 8005-139, Faro, Portugal. rgmartinho@ua.pt.; Departmento de Ciências Médicas, Universidade de Aveiro, 3810-193, Aveiro, Portugal. rgmartinho@ua.pt.; iBiMED - Institute of Biomedicine, Universidade de Aveiro, 3810-193, Aveiro, Portugal. rgmartinho@ua.pt.<br /><searchLink fieldCode="AU" term="%22Arnesen+T%22">Arnesen T</searchLink>; Department of Biomedicine, University of Bergen, N-5021, Bergen, Norway. thomas.arnesen@uib.no.; Department of Biological Sciences, University of Bergen, N-5006, Bergen, Norway. thomas.arnesen@uib.no.; Department of Surgery, Haukeland University Hospital, N-5021, Bergen, Norway. thomas.arnesen@uib.no.
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