CD3ζ ITAMs enable ligand discrimination and antagonism by inhibiting TCR signaling in response to low-affinity peptides.
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| Title: | CD3ζ ITAMs enable ligand discrimination and antagonism by inhibiting TCR signaling in response to low-affinity peptides. |
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| Authors: | Gaud G; Hematopoiesis and Lymphocyte Biology Section, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, Bethesda, MD, USA., Achar S; Immunodynamics Section, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Bourassa FXP; Département de Biochimie et Médecine Moléculaire, Université de Montréal, Montréal, Quebec, Canada.; Department of Physics, McGill University, Montréal QC, Canada., Davies J; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.; Department of Safety Assessment, Genentech, Inc., San Francisco, CA, USA., Hatzihristidis T; Hematopoiesis and Lymphocyte Biology Section, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, Bethesda, MD, USA., Choi S; Hematopoiesis and Lymphocyte Biology Section, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, Bethesda, MD, USA., Kondo T; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Gossa S; Viral Immunology & Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Lee J; Hematopoiesis and Lymphocyte Biology Section, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, Bethesda, MD, USA., Juneau P; National Institutes of Health Library, Office of Research Services, National Institutes of Health, Bethesda, MD, USA., Taylor N; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Hinrichs CS; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.; Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA., McGavern DB; Viral Immunology & Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., François P; Département de Biochimie et Médecine Moléculaire, Université de Montréal, Montréal, Quebec, Canada.; Mila Québec, Montréal, Quebec, Canada., Altan-Bonnet G; Immunodynamics Section, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Love PE; Hematopoiesis and Lymphocyte Biology Section, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, Bethesda, MD, USA. lovep@mail.nih.gov. |
| Source: | Nature immunology [Nat Immunol] 2023 Dec; Vol. 24 (12), pp. 2121-2134. Date of Electronic Publication: 2023 Nov 09. |
| Publication Type: | Journal Article; Research Support, N.I.H., Intramural |
| Journal Info: | Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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