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A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan.

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Title: A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan.
Authors: Chamoli M; Buck Institute for Research on Aging, Novato, CA, USA. mchamoli@buckinstitute.org., Rane A; Buck Institute for Research on Aging, Novato, CA, USA., Foulger A; Buck Institute for Research on Aging, Novato, CA, USA., Chinta SJ; Buck Institute for Research on Aging, Novato, CA, USA.; Touro University California, Vallejo, CA, USA., Shahmirzadi AA; Buck Institute for Research on Aging, Novato, CA, USA.; University of Southern California, Los Angeles, CA, USA., Kumsta C; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Nambiar DK; Stanford University, Stanford, CA, USA., Hall D; Buck Institute for Research on Aging, Novato, CA, USA., Holcom A; Buck Institute for Research on Aging, Novato, CA, USA.; University of Southern California, Los Angeles, CA, USA., Angeli S; Buck Institute for Research on Aging, Novato, CA, USA., Schmidt M; Buck Institute for Research on Aging, Novato, CA, USA.; University of Southern California, Los Angeles, CA, USA., Pitteri S; Stanford University, Stanford, CA, USA., Hansen M; Buck Institute for Research on Aging, Novato, CA, USA.; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Lithgow GJ; Buck Institute for Research on Aging, Novato, CA, USA. glithgow@buckinstitute.org., Andersen JK; Buck Institute for Research on Aging, Novato, CA, USA. jkandersen@buckinstitute.org.
Source: Nature aging [Nat Aging] 2023 Dec; Vol. 3 (12), pp. 1529-1543. Date of Electronic Publication: 2023 Nov 13.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group US Country of Publication: United States NLM ID: 101773306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8465 (Electronic) Linking ISSN: 26628465 NLM ISO Abbreviation: Nat Aging Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan.
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  Data: <searchLink fieldCode="AU" term="%22Chamoli+M%22">Chamoli M</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA. mchamoli@buckinstitute.org.<br /><searchLink fieldCode="AU" term="%22Rane+A%22">Rane A</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22Foulger+A%22">Foulger A</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chinta+SJ%22">Chinta SJ</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.; Touro University California, Vallejo, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shahmirzadi+AA%22">Shahmirzadi AA</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.; University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kumsta+C%22">Kumsta C</searchLink>; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nambiar+DK%22">Nambiar DK</searchLink>; Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hall+D%22">Hall D</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22Holcom+A%22">Holcom A</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.; University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Angeli+S%22">Angeli S</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22Schmidt+M%22">Schmidt M</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.; University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Pitteri+S%22">Pitteri S</searchLink>; Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hansen+M%22">Hansen M</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lithgow+GJ%22">Lithgow GJ</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA. glithgow@buckinstitute.org.<br /><searchLink fieldCode="AU" term="%22Andersen+JK%22">Andersen JK</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA. jkandersen@buckinstitute.org.
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  Data: <searchLink fieldCode="JN" term="%22101773306%22">Nature aging</searchLink> [Nat Aging] 2023 Dec; Vol. 3 (12), pp. 1529-1543. <i>Date of Electronic Publication: </i>2023 Nov 13.
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              Text: 2023 Dec
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