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Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells.

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Title: Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells.
Authors: Linder SJ; The Krantz Family Center for Cancer Research, The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Bernasocchi T; The Krantz Family Center for Cancer Research, The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA. tbernasocchi@mgh.harvard.edu.; Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Denver, CO, USA. tbernasocchi@mgh.harvard.edu., Martínez-Pastor B; The Krantz Family Center for Cancer Research, The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.; Spanish National Cancer Research Center (CNIO), Madrid, Spain., Sullivan KD; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Section of Developmental Biology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Galbraith MD; Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Denver, CO, USA.; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Lewis CA; The Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Ferrer CM; The Krantz Family Center for Cancer Research, The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA., Boon R; The Krantz Family Center for Cancer Research, The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Galapagos de Wittelaan, Mechelen, Belgium., Silveira GG; The Krantz Family Center for Cancer Research, The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA., Cho HM; The Krantz Family Center for Cancer Research, The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA., Vidoudez C; Harvard Center for Mass Spectrometry, Cambridge, MA, USA., Shroff S; Department of Pathology, The Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Oliveira-Costa JP; The Krantz Family Center for Cancer Research, The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Takeda Pharmaceuticals, Cambridge, MA, USA., Ross KN; Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Massri R; The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel., Matoba Y; Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA, USA.; Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA., Kim E; Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA, USA.; Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA., Rueda BR; Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA, USA.; Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA., Stott SL; The Krantz Family Center for Cancer Research, The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Center for Engineering in Medicine and Surgery, The Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, MA, USA., Gottlieb E; The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.; MD Anderson Cancer Center, Houston, TX, USA., Espinosa JM; Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Denver, CO, USA.; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Mostoslavsky R; The Krantz Family Center for Cancer Research, The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA. rmostoslavsky@mgh.harvard.edu.; Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Denver, CO, USA. rmostoslavsky@mgh.harvard.edu.
Source: Nature metabolism [Nat Metab] 2023 Dec; Vol. 5 (12), pp. 2131-2147. Date of Electronic Publication: 2023 Nov 13.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
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  Data: Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells.
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  Data: <searchLink fieldCode="AU" term="%22Linder+SJ%22">Linder SJ</searchLink>; The Krantz Family Center for Cancer Research, The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bernasocchi+T%22">Bernasocchi T</searchLink>; The Krantz Family Center for Cancer Research, The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA. tbernasocchi@mgh.harvard.edu.; Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Denver, CO, USA. tbernasocchi@mgh.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Martínez-Pastor+B%22">Martínez-Pastor B</searchLink>; The Krantz Family Center for Cancer Research, The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.; Spanish National Cancer Research Center (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Sullivan+KD%22">Sullivan KD</searchLink>; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; 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MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Espinosa+JM%22">Espinosa JM</searchLink>; Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Denver, CO, USA.; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Mostoslavsky+R%22">Mostoslavsky R</searchLink>; The Krantz Family Center for Cancer Research, The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA. rmostoslavsky@mgh.harvard.edu.; Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Denver, CO, USA. rmostoslavsky@mgh.harvard.edu.
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