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Combining the Tyrosine Kinase Inhibitor Cabozantinib and the mTORC1/2 Inhibitor Sapanisertib Blocks ERK Pathway Activity and Suppresses Tumor Growth in Renal Cell Carcinoma.

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Title: Combining the Tyrosine Kinase Inhibitor Cabozantinib and the mTORC1/2 Inhibitor Sapanisertib Blocks ERK Pathway Activity and Suppresses Tumor Growth in Renal Cell Carcinoma.
Authors: Wu Y; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, Missouri., Chen S; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, Missouri., Yang X; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri., Sato K; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, Missouri., Lal P; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri., Wang Y; Department of Pathology, Johns Hopkins University, Baltimore, Maryland., Shinkle AT; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri., Wendl MC; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, Missouri.; Department of Genetics, Washington University in St. Louis, St. Louis, Missouri.; McKelvey School of Engineering, Washington University in St. Louis, St. Louis, Missouri., Primeau TM; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri., Zhao Y; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri., Gould A; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri., Sun H; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, Missouri., Mudd JL; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri., Hoog J; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri., Mashl RJ; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, Missouri., Wyczalkowski MA; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, Missouri., Mo CK; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, Missouri., Liu R; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, Missouri., Herndon JM; Siteman Cancer Center, Washington University in St. Louis, St. Louis, Missouri.; Department of Surgery, Washington University in St. Louis, St. Louis, Missouri., Davies SR; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri., Liu D; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri., Ding X; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri., Evrard YA; Frederick National Laboratory for Cancer Research, Frederick, Maryland., Welm BE; Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah., Lum D; Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah., Koh MY; Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah., Welm AL; Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah., Chuang JH; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut., Moscow JA; Investigational Drug Branch, National Cancer Institute, Bethesda, Maryland., Meric-Bernstam F; The University of Texas MD Anderson Cancer Center, Houston, Texas., Govindan R; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.; Department of Genetics, Washington University in St. Louis, St. Louis, Missouri., Li S; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.; Department of Genetics, Washington University in St. Louis, St. Louis, Missouri., Hsieh J; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri., Fields RC; Department of Genetics, Washington University in St. Louis, St. Louis, Missouri., Lim KH; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.; Department of Genetics, Washington University in St. Louis, St. Louis, Missouri., Ma CX; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.; Department of Genetics, Washington University in St. Louis, St. Louis, Missouri., Zhang H; Department of Pathology, Johns Hopkins University, Baltimore, Maryland., Ding L; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, Missouri.; Department of Genetics, Washington University in St. Louis, St. Louis, Missouri.; Siteman Cancer Center, Washington University in St. Louis, St. Louis, Missouri., Chen F; Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.; Department of Genetics, Washington University in St. Louis, St. Louis, Missouri.
Source: Cancer research [Cancer Res] 2023 Dec 15; Vol. 83 (24), pp. 4161-4178.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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