Sequential immunotherapy and targeted therapy for metastatic BRAF V600 mutated melanoma: 4-year survival and biomarkers evaluation from the phase II SECOMBIT trial.
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| Title: | Sequential immunotherapy and targeted therapy for metastatic BRAF V600 mutated melanoma: 4-year survival and biomarkers evaluation from the phase II SECOMBIT trial. |
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| Authors: | Ascierto PA; Department of Melanoma, Cancer Immunotherapy and Development Therapeutics. I.N.T. IRCCS Fondazione 'G. Pascale', Napoli, Italy. p.ascierto@istitutotumori.na.it., Casula M; Immuno-Oncology & Targeted Cancer Biotherapies, University of Sassari - Unit of Cancer Genetics, IRGB-CNR, 07100, Sassari, Italy., Bulgarelli J; Immunotherapy, Cell Therapy Unit and Biobank Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., Pisano M; Immuno-Oncology & Targeted Cancer Biotherapies, University of Sassari - Unit of Cancer Genetics, IRGB-CNR, 07100, Sassari, Italy., Piccinini C; Immunotherapy, Cell Therapy Unit and Biobank Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., Piccin L; Melanoma Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy., Cossu A; Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy., Mandalà M; University of Perugia, Perugia, Italy.; Department of Oncology and Haematology, Papa Giovanni XXIII Cancer Center Hospital, Bergamo, Italy., Ferrucci PF; Biotherapy of Tumors Unit, Department of Experimental Oncology, European Institute of Oncology, IRCCS, Milan, Italy., Guidoboni M; Immunotherapy, Cell Therapy Unit and Biobank Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., Rutkowski P; Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska Curie National Research Institute of Oncology, 02-781 -, Warsaw, Poland., Ferraresi V; Department of Medical Oncology 1, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Arance A; Department of Medical Oncology, Hospital Clínic Barcelona, 08036, Barcelona, Spain., Guida M; Rare Tumors and Melanoma Unit, IRCCS Istituto dei Tumori 'Giovanni Paolo II', Bari, Italy., Maiello E; Oncology Unit, Foundation IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Gogas H; First Department of Medicine, National and Kapodistrian University of Athens, Athens, Greece., Richtig E; Department of Dermatology, Medical University of Graz, Graz, Austria., Fierro MT; Department of Medical Sciences, Dermatologic Clinic, University of Turin, Turin, Italy., Lebbe C; Dermato-Oncology and CIC AP-HP Hôpital Saint Louis,Cancer Institute APHP. Nord-Université Paris Cite F-75010, Paris, INSERM U976, France., Helgadottir H; Department of Oncology-Pathology, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden., Queirolo P; Skin Cancer Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy.; Division of melanoma Sarcoma and Rare Tumors, IRCCS European Institute of Oncology, Milan, Italy., Spagnolo F; Skin Cancer Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Tucci M; Department of Interdisciplinary Medicine, Oncology Unit, University of Bari 'Aldo Moro', Bari, Italy., Del Vecchio M; Unit of Melanoma Medical Oncology, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Cao MG; Department of Medical Oncology, University Hospital Dexeus, Barcelona, Spain., Minisini AM; Academic Hospital 'Santa Maria della Misericordia', Udine, Italy., De Placido S; Department of Clinical Medicine and Surgery, University of Naples 'Federico II', Naples, Italy., Sanmamed MF; Department of Interdisciplinary Medicine, Oncology Unit, University of Bari 'Aldo Moro', Bari, Italy., Mallardo D; Department of Melanoma, Cancer Immunotherapy and Development Therapeutics. I.N.T. IRCCS Fondazione 'G. Pascale', Napoli, Italy., Paone M; Department of Melanoma, Cancer Immunotherapy and Development Therapeutics. I.N.T. IRCCS Fondazione 'G. Pascale', Napoli, Italy., Vitale MG; Department of Melanoma, Cancer Immunotherapy and Development Therapeutics. I.N.T. IRCCS Fondazione 'G. Pascale', Napoli, Italy., Melero I; Department of Immunology and Oncology, Clínica Universidad de Navarra, Pamplona, Spain., Grimaldi AM; Department of Melanoma, Cancer Immunotherapy and Development Therapeutics. I.N.T. IRCCS Fondazione 'G. Pascale', Napoli, Italy.; Medical Oncology Unit, AORN San Pio, Benevento, Italy., Giannarelli D; Fondazione Policlinico Universitario A. Gemelli, IRCCS - Facility of Epidemiology and Biostatistics, Rome, Italy., Dummer R; Department of Dermatology, University and University Hospital Zurich, Zurich, Switzerland., Sileni VC; Melanoma Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy., Palmieri G; Immuno-Oncology & Targeted Cancer Biotherapies, University of Sassari - Unit of Cancer Genetics, IRGB-CNR, 07100, Sassari, Italy. |
| Source: | Nature communications [Nat Commun] 2024 Jan 02; Vol. 15 (1), pp. 146. Date of Electronic Publication: 2024 Jan 02. |
| Publication Type: | Randomized Controlled Trial; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 38167503 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Sequential immunotherapy and targeted therapy for metastatic BRAF V600 mutated melanoma: 4-year survival and biomarkers evaluation from the phase II SECOMBIT trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Ascierto+PA%22">Ascierto PA</searchLink>; Department of Melanoma, Cancer Immunotherapy and Development Therapeutics. I.N.T. IRCCS Fondazione 'G. Pascale', Napoli, Italy. p.ascierto@istitutotumori.na.it.<br /><searchLink fieldCode="AU" term="%22Casula+M%22">Casula M</searchLink>; Immuno-Oncology & Targeted Cancer Biotherapies, University of Sassari - Unit of Cancer Genetics, IRGB-CNR, 07100, Sassari, Italy.<br /><searchLink fieldCode="AU" term="%22Bulgarelli+J%22">Bulgarelli J</searchLink>; Immunotherapy, Cell Therapy Unit and Biobank Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy.<br /><searchLink fieldCode="AU" term="%22Pisano+M%22">Pisano M</searchLink>; Immuno-Oncology & Targeted Cancer Biotherapies, University of Sassari - Unit of Cancer Genetics, IRGB-CNR, 07100, Sassari, Italy.<br /><searchLink fieldCode="AU" term="%22Piccinini+C%22">Piccinini C</searchLink>; Immunotherapy, Cell Therapy Unit and Biobank Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy.<br /><searchLink fieldCode="AU" term="%22Piccin+L%22">Piccin L</searchLink>; Melanoma Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Cossu+A%22">Cossu A</searchLink>; Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy.<br /><searchLink fieldCode="AU" term="%22Mandalà+M%22">Mandalà M</searchLink>; University of Perugia, Perugia, Italy.; Department of Oncology and Haematology, Papa Giovanni XXIII Cancer Center Hospital, Bergamo, Italy.<br /><searchLink fieldCode="AU" term="%22Ferrucci+PF%22">Ferrucci PF</searchLink>; Biotherapy of Tumors Unit, Department of Experimental Oncology, European Institute of Oncology, IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Guidoboni+M%22">Guidoboni M</searchLink>; Immunotherapy, Cell Therapy Unit and Biobank Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy.<br /><searchLink fieldCode="AU" term="%22Rutkowski+P%22">Rutkowski P</searchLink>; Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska Curie National Research Institute of Oncology, 02-781 -, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Ferraresi+V%22">Ferraresi V</searchLink>; Department of Medical Oncology 1, IRCCS Regina Elena National Cancer Institute, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Arance+A%22">Arance A</searchLink>; Department of Medical Oncology, Hospital Clínic Barcelona, 08036, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Guida+M%22">Guida M</searchLink>; Rare Tumors and Melanoma Unit, IRCCS Istituto dei Tumori 'Giovanni Paolo II', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Maiello+E%22">Maiello E</searchLink>; Oncology Unit, Foundation IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.<br /><searchLink fieldCode="AU" term="%22Gogas+H%22">Gogas H</searchLink>; First Department of Medicine, National and Kapodistrian University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Richtig+E%22">Richtig E</searchLink>; Department of Dermatology, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Fierro+MT%22">Fierro MT</searchLink>; Department of Medical Sciences, Dermatologic Clinic, University of Turin, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Lebbe+C%22">Lebbe C</searchLink>; Dermato-Oncology and CIC AP-HP Hôpital Saint Louis,Cancer Institute APHP. Nord-Université Paris Cite F-75010, Paris, INSERM U976, France.<br /><searchLink fieldCode="AU" term="%22Helgadottir+H%22">Helgadottir H</searchLink>; Department of Oncology-Pathology, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Queirolo+P%22">Queirolo P</searchLink>; Skin Cancer Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy.; Division of melanoma Sarcoma and Rare Tumors, IRCCS European Institute of Oncology, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Spagnolo+F%22">Spagnolo F</searchLink>; Skin Cancer Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy.<br /><searchLink fieldCode="AU" term="%22Tucci+M%22">Tucci M</searchLink>; Department of Interdisciplinary Medicine, Oncology Unit, University of Bari 'Aldo Moro', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Del+Vecchio+M%22">Del Vecchio M</searchLink>; Unit of Melanoma Medical Oncology, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Cao+MG%22">Cao MG</searchLink>; Department of Medical Oncology, University Hospital Dexeus, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Minisini+AM%22">Minisini AM</searchLink>; Academic Hospital 'Santa Maria della Misericordia', Udine, Italy.<br /><searchLink fieldCode="AU" term="%22De+Placido+S%22">De Placido S</searchLink>; Department of Clinical Medicine and Surgery, University of Naples 'Federico II', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Sanmamed+MF%22">Sanmamed MF</searchLink>; Department of Interdisciplinary Medicine, Oncology Unit, University of Bari 'Aldo Moro', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Mallardo+D%22">Mallardo D</searchLink>; Department of Melanoma, Cancer Immunotherapy and Development Therapeutics. I.N.T. IRCCS Fondazione 'G. Pascale', Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Paone+M%22">Paone M</searchLink>; Department of Melanoma, Cancer Immunotherapy and Development Therapeutics. I.N.T. IRCCS Fondazione 'G. Pascale', Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Vitale+MG%22">Vitale MG</searchLink>; Department of Melanoma, Cancer Immunotherapy and Development Therapeutics. I.N.T. IRCCS Fondazione 'G. Pascale', Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Melero+I%22">Melero I</searchLink>; Department of Immunology and Oncology, Clínica Universidad de Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Grimaldi+AM%22">Grimaldi AM</searchLink>; Department of Melanoma, Cancer Immunotherapy and Development Therapeutics. I.N.T. IRCCS Fondazione 'G. Pascale', Napoli, Italy.; Medical Oncology Unit, AORN San Pio, Benevento, Italy.<br /><searchLink fieldCode="AU" term="%22Giannarelli+D%22">Giannarelli D</searchLink>; Fondazione Policlinico Universitario A. Gemelli, IRCCS - Facility of Epidemiology and Biostatistics, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Dummer+R%22">Dummer R</searchLink>; Department of Dermatology, University and University Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Sileni+VC%22">Sileni VC</searchLink>; Melanoma Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Palmieri+G%22">Palmieri G</searchLink>; Immuno-Oncology & Targeted Cancer Biotherapies, University of Sassari - Unit of Cancer Genetics, IRGB-CNR, 07100, Sassari, Italy. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2024 Jan 02; Vol. 15 (1), pp. 146. <i>Date of Electronic Publication: </i>2024 Jan 02. – Name: TypePub Label: Publication Type Group: TypPub Data: Randomized Controlled Trial; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE |
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