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Multi-omic and functional analysis for classification and treatment of sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions.

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Title: Multi-omic and functional analysis for classification and treatment of sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions.
Authors: Schöpf J; Division of Applied Functional Genomics, German Cancer Research Center (DKFZ), and National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Translational Medical Oncology, DKFZ, and NCT Heidelberg, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Uhrig S; Computational Oncology Group, Molecular Precision Oncology Program, NCT Heidelberg, and DKFZ, Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany., Heilig CE; Division of Translational Medical Oncology, DKFZ, and NCT Heidelberg, Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany., Lee KS; Division of Translational Medical Oncology, DKFZ, and NCT Heidelberg, Heidelberg, Germany., Walther T; Division of Translational Medical Oncology, DKFZ, and NCT Heidelberg, Heidelberg, Germany., Carazzato A; Division of Translational Medical Oncology, DKFZ, and NCT Heidelberg, Heidelberg, Germany., Dobberkau AM; Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, DKFZ, and NCT Heidelberg, Heidelberg, Germany., Weichenhan D; Division of Cancer Epigenomics, DKFZ, Heidelberg, Germany., Plass C; Division of Cancer Epigenomics, DKFZ, Heidelberg, Germany., Hartmann M; Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, DKFZ, and NCT Heidelberg, Heidelberg, Germany., Diwan GD; Bioquant, Heidelberg University, Heidelberg, Germany.; Heidelberg University Biochemistry Center (BZH), Heidelberg, Germany., Carrero ZI; Department for Translational Medical Oncology, NCT, NCT/UCC Dresden, a Partnership Between DKFZ, Heidelberg Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; German Cancer Consortium (DKTK), Dresden, Germany., Ball CR; Department for Translational Medical Oncology, NCT, NCT/UCC Dresden, a Partnership Between DKFZ, Heidelberg Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; German Cancer Consortium (DKTK), Dresden, Germany.; Translational Medical Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD, Dresden, Germany.; Faculty of Biology, TUD Dresden University of Technology, Dresden, Germany., Hohl T; Division of Applied Functional Genomics, German Cancer Research Center (DKFZ), and National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Kindler T; University Cancer Center Mainz, Johannes Gutenberg University Mainz, Mainz, Germany.; Department of Hematology, Medical Oncology and Pneumology, University Medical Center, Mainz, Germany.; German Cancer Consortium (DKTK), Mainz, Germany., Rudolph-Hähnel P; University Cancer Center Mainz, Johannes Gutenberg University Mainz, Mainz, Germany.; Department of Hematology, Medical Oncology and Pneumology, University Medical Center, Mainz, Germany.; German Cancer Consortium (DKTK), Mainz, Germany., Helm D; Proteomics Core Facility, DKFZ, Heidelberg, Germany., Schneider M; Proteomics Core Facility, DKFZ, Heidelberg, Germany., Nilsson A; Pediatric Oncology and Coagulation, Karolinska University Hospital, Stockholm, Sweden., Øra I; Pediatric Oncology and Hematology, Skåne University Hospital, Lund University, Lund, Sweden., Imle R; Soft-Tissue Sarcoma Junior Research Group, DKFZ, Heidelberg, Germany.; Hopp Children's Cancer Center (KiTZ) and NCT Heidelberg, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany., Banito A; Soft-Tissue Sarcoma Junior Research Group, DKFZ, Heidelberg, Germany.; Hopp Children's Cancer Center (KiTZ) and NCT Heidelberg, Heidelberg, Germany., Russell RB; Bioquant, Heidelberg University, Heidelberg, Germany.; Heidelberg University Biochemistry Center (BZH), Heidelberg, Germany., Jones BC; German Cancer Consortium (DKTK), Heidelberg, Germany.; Hopp Children's Cancer Center (KiTZ) and NCT Heidelberg, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany., Lipka DB; Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, DKFZ, and NCT Heidelberg, Heidelberg, Germany., Glimm H; Department for Translational Medical Oncology, NCT, NCT/UCC Dresden, a Partnership Between DKFZ, Heidelberg Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; German Cancer Consortium (DKTK), Dresden, Germany.; Translational Medical Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD, Dresden, Germany.; Translational Functional Cancer Genomics, DKFZ, Heidelberg, Germany., Hübschmann D; Computational Oncology Group, Molecular Precision Oncology Program, NCT Heidelberg, and DKFZ, Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Pattern Recognition and Digital Medicine Group, Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany., Hartmann W; Gerhard Domagk Institute of Pathology, University Hospital Münster, Münster, Germany., Fröhling S; Division of Translational Medical Oncology, DKFZ, and NCT Heidelberg, Heidelberg, Germany. stefan.froehling@nct-heidelberg.de.; German Cancer Consortium (DKTK), Heidelberg, Germany. stefan.froehling@nct-heidelberg.de.; Institute of Human Genetics, Heidelberg University, Heidelberg, Germany. stefan.froehling@nct-heidelberg.de., Scholl C; Division of Applied Functional Genomics, German Cancer Research Center (DKFZ), and National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany. claudia.scholl@nct-heidelberg.de.
Source: Nature communications [Nat Commun] 2024 Jan 02; Vol. 15 (1), pp. 51. Date of Electronic Publication: 2024 Jan 02.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Schöpf+J%22">Schöpf J</searchLink>; Division of Applied Functional Genomics, German Cancer Research Center (DKFZ), and National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Translational Medical Oncology, DKFZ, and NCT Heidelberg, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Uhrig+S%22">Uhrig S</searchLink>; Computational Oncology Group, Molecular Precision Oncology Program, NCT Heidelberg, and DKFZ, Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Heilig+CE%22">Heilig CE</searchLink>; Division of Translational Medical Oncology, DKFZ, and NCT Heidelberg, Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Lee+KS%22">Lee KS</searchLink>; 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