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Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability.

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Title: Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability.
Authors: Gorman J; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Cheung CS; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Duan Z; NCI Antibody Engineering Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Ou L; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Wang M; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, 10032, USA., Chen X; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Cheng C; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Biju A; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Sun Y; NCI Antibody Engineering Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Wang P; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, 10032, USA., Yang Y; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Zhang B; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Boyington JC; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Bylund T; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Charaf S; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Chen SJ; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Du H; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Henry AR; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Liu T; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Sarfo EK; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Schramm CA; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Shen CH; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Stephens T; Electron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA., Teng IT; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Todd JP; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Tsybovsky Y; Electron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA., Verardi R; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Wang D; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Wang S; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Wang Z; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Zheng CY; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Zhou T; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Douek DC; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Mascola JR; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA., Ho DD; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, 10032, USA. dh2994@cumc.columbia.edu., Ho M; NCI Antibody Engineering Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA. homi@mail.nih.gov., Kwong PD; Vaccine Research Center, National Institutes of Health, Bethesda, MD, 20892, USA. pdkwong@nih.gov.
Source: Nature communications [Nat Commun] 2024 Jan 04; Vol. 15 (1), pp. 285. Date of Electronic Publication: 2024 Jan 04.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability.
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