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TREX1 Inactivation Unleashes Cancer Cell STING-Interferon Signaling and Promotes Antitumor Immunity.

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Title: TREX1 Inactivation Unleashes Cancer Cell STING-Interferon Signaling and Promotes Antitumor Immunity.
Authors: Tani T; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Mathsyaraja H; Gilead Sciences, Foster City, California., Campisi M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Li ZH; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Haratani K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Fahey CG; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Ota K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Mahadevan NR; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts., Shi Y; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Saito S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Mizuno K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Thai TC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Sasaki N; Department of Cell Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan., Homme M; Department of Cell Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan., Yusuf CFB; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts., Kashishian A; Gilead Sciences, Foster City, California., Panchal J; Gilead Sciences, Foster City, California., Wang M; Gilead Sciences, Foster City, California., Wolf BJ; Gilead Sciences, Foster City, California., Barbie TU; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Paweletz CP; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts., Gokhale PC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts., Liu D; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Uppaluri R; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Kitajima S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Cell Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan., Cain J; Gilead Sciences, Foster City, California., Barbie DA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Source: Cancer discovery [Cancer Discov] 2024 May 01; Vol. 14 (5), pp. 752-765.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: TREX1 Inactivation Unleashes Cancer Cell STING-Interferon Signaling and Promotes Antitumor Immunity.
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  Data: <searchLink fieldCode="AU" term="%22Tani+T%22">Tani T</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Mathsyaraja+H%22">Mathsyaraja H</searchLink>; Gilead Sciences, Foster City, California.<br /><searchLink fieldCode="AU" term="%22Campisi+M%22">Campisi M</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Li+ZH%22">Li ZH</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Haratani+K%22">Haratani K</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Fahey+CG%22">Fahey CG</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Ota+K%22">Ota K</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Mahadevan+NR%22">Mahadevan NR</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Shi+Y%22">Shi Y</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Saito+S%22">Saito S</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Mizuno+K%22">Mizuno K</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Thai+TC%22">Thai TC</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Sasaki+N%22">Sasaki N</searchLink>; Department of Cell Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Homme+M%22">Homme M</searchLink>; Department of Cell Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yusuf+CFB%22">Yusuf CFB</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Kashishian+A%22">Kashishian A</searchLink>; Gilead Sciences, Foster City, California.<br /><searchLink fieldCode="AU" term="%22Panchal+J%22">Panchal J</searchLink>; Gilead Sciences, Foster City, California.<br /><searchLink fieldCode="AU" term="%22Wang+M%22">Wang M</searchLink>; Gilead Sciences, Foster City, California.<br /><searchLink fieldCode="AU" term="%22Wolf+BJ%22">Wolf BJ</searchLink>; Gilead Sciences, Foster City, California.<br /><searchLink fieldCode="AU" term="%22Barbie+TU%22">Barbie TU</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Paweletz+CP%22">Paweletz CP</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Gokhale+PC%22">Gokhale PC</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Liu+D%22">Liu D</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Uppaluri+R%22">Uppaluri R</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Kitajima+S%22">Kitajima S</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Cell Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Cain+J%22">Cain J</searchLink>; Gilead Sciences, Foster City, California.<br /><searchLink fieldCode="AU" term="%22Barbie+DA%22">Barbie DA</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101561693 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2159-8290 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221598274%22">21598274 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Discov <i>Subsets: </i>MEDLINE
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