A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneity.
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| Title: | A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneity. |
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| Authors: | Patel AG; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.; These authors contributed equally., Ashenberg O; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; These authors contributed equally., Collins NB; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, USA.; These authors contributed equally., Segerstolpe Å; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jiang S; Department of Pathology, Stanford University, Stanford, CA, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Slyper M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Huang X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Caraccio C; Department of Pathology, Stanford University, Stanford, CA, USA., Jin H; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA., Sheppard H; Comparative Pathology Core, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Xu K; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA., Chang TC; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA., Orr BA; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Shirinifard A; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA., Chapple RH; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Shen A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Clay MR; Department of Pathology, University of Colorado School of Medicine, Aurora, CO, USA., Tatevossian RG; Cancer Biomarkers Laboratory, St. Jude Children's Research Hospital, Memphis, TN, USA., Reilly C; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Patel J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Lupo M; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA., Cline C; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA., Dionne D; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Porter CBM; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Waldman J; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bai Y; Department of Pathology, Stanford University, Stanford, CA, USA., Zhu B; Department of Pathology, Stanford University, Stanford, CA, USA., Barrera I; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Murray E; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Vigneau S; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Napolitano S; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Wakiro I; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Wu J; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Grimaldi G; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Dellostritto L; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Helvie K; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Rotem A; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Lako A; Center for Immuno-Oncology (CIO), Dana-Farber Cancer Institute, Boston, MA, USA., Cullen N; Center for Immuno-Oncology (CIO), Dana-Farber Cancer Institute, Boston, MA, USA., Pfaff KL; Center for Immuno-Oncology (CIO), Dana-Farber Cancer Institute, Boston, MA, USA., Karlström Å; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA., Jané-Valbuena J; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Todres E; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Thorner A; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Geeleher P; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Rodig SJ; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Zhou X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Stewart E; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA., Johnson BE; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Wu G; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Chen F; Broad Institute of MIT and Harvard, Boston, MA, USA., Yu J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Goltsev Y; Department of Pathology, Stanford University, Stanford, CA, USA., Nolan GP; Department of Pathology, Stanford University, Stanford, CA, USA., Rozenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Current address: Research and Early Development, Genentech Inc., South San Francisco, CA, 94080, USA., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Koch Institute of Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Current address: Research and Early Development, Genentech Inc., South San Francisco, CA, 94080, USA.; Lead contacts., Dyer MA; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Lead contacts. |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2024 Jan 16. Date of Electronic Publication: 2024 Jan 16. |
| Publication Type: | Preprint; Journal Article |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 38260392 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneity. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Patel+AG%22">Patel AG</searchLink>; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.; These authors contributed equally.<br /><searchLink fieldCode="AU" term="%22Ashenberg+O%22">Ashenberg O</searchLink>; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; These authors contributed equally.<br /><searchLink fieldCode="AU" term="%22Collins+NB%22">Collins NB</searchLink>; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, USA.; These authors contributed equally.<br /><searchLink fieldCode="AU" term="%22Segerstolpe+Å%22">Segerstolpe Å</searchLink>; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+S%22">Jiang S</searchLink>; Department of Pathology, Stanford University, Stanford, CA, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Slyper+M%22">Slyper M</searchLink>; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Huang+X%22">Huang X</searchLink>; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Caraccio+C%22">Caraccio C</searchLink>; Department of Pathology, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jin+H%22">Jin H</searchLink>; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Sheppard+H%22">Sheppard H</searchLink>; Comparative Pathology Core, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Xu+K%22">Xu K</searchLink>; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Chang+TC%22">Chang TC</searchLink>; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Orr+BA%22">Orr BA</searchLink>; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Shirinifard+A%22">Shirinifard A</searchLink>; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Chapple+RH%22">Chapple RH</searchLink>; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Shen+A%22">Shen A</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Clay+MR%22">Clay MR</searchLink>; Department of Pathology, University of Colorado School of Medicine, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Tatevossian+RG%22">Tatevossian RG</searchLink>; Cancer Biomarkers Laboratory, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Reilly+C%22">Reilly C</searchLink>; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Patel+J%22">Patel J</searchLink>; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Lupo+M%22">Lupo M</searchLink>; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Cline+C%22">Cline C</searchLink>; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Dionne+D%22">Dionne D</searchLink>; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Porter+CBM%22">Porter CBM</searchLink>; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Waldman+J%22">Waldman J</searchLink>; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bai+Y%22">Bai Y</searchLink>; Department of Pathology, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+B%22">Zhu B</searchLink>; Department of Pathology, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Barrera+I%22">Barrera I</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Murray+E%22">Murray E</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Vigneau+S%22">Vigneau S</searchLink>; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Napolitano+S%22">Napolitano S</searchLink>; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wakiro+I%22">Wakiro I</searchLink>; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Grimaldi+G%22">Grimaldi G</searchLink>; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dellostritto+L%22">Dellostritto L</searchLink>; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Helvie+K%22">Helvie K</searchLink>; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rotem+A%22">Rotem A</searchLink>; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lako+A%22">Lako A</searchLink>; Center for Immuno-Oncology (CIO), Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cullen+N%22">Cullen N</searchLink>; Center for Immuno-Oncology (CIO), Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pfaff+KL%22">Pfaff KL</searchLink>; Center for Immuno-Oncology (CIO), Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Karlström+Å%22">Karlström Å</searchLink>; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Jané-Valbuena+J%22">Jané-Valbuena J</searchLink>; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Todres+E%22">Todres E</searchLink>; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Thorner+A%22">Thorner A</searchLink>; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Geeleher+P%22">Geeleher P</searchLink>; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Rodig+SJ%22">Rodig SJ</searchLink>; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Stewart+E%22">Stewart E</searchLink>; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+BE%22">Johnson BE</searchLink>; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wu+G%22">Wu G</searchLink>; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Chen+F%22">Chen F</searchLink>; Broad Institute of MIT and Harvard, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yu+J%22">Yu J</searchLink>; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Goltsev+Y%22">Goltsev Y</searchLink>; Department of Pathology, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nolan+GP%22">Nolan GP</searchLink>; Department of Pathology, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rozenblatt-Rosen+O%22">Rozenblatt-Rosen O</searchLink>; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Current address: Research and Early Development, Genentech Inc., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Regev+A%22">Regev A</searchLink>; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Koch Institute of Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Current address: Research and Early Development, Genentech Inc., South San Francisco, CA, 94080, USA.; Lead contacts.<br /><searchLink fieldCode="AU" term="%22Dyer+MA%22">Dyer MA</searchLink>; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Lead contacts. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2024 Jan 16. <i>Date of Electronic Publication: </i>2024 Jan 16. – Name: TypePub Label: Publication Type Group: TypPub Data: Preprint; 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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1101/2024.01.07.574538 Languages: – Code: eng Text: English Titles: – TitleFull: A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneity. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Patel AG – PersonEntity: Name: NameFull: Ashenberg O – PersonEntity: Name: NameFull: Collins NB – PersonEntity: Name: NameFull: Segerstolpe Å – PersonEntity: Name: NameFull: Jiang S – PersonEntity: Name: NameFull: Slyper M – PersonEntity: Name: NameFull: Huang X – PersonEntity: Name: NameFull: Caraccio C – PersonEntity: Name: NameFull: Jin H – PersonEntity: Name: NameFull: Sheppard H – PersonEntity: Name: NameFull: Xu K – PersonEntity: Name: NameFull: Chang TC – PersonEntity: Name: NameFull: Orr BA – PersonEntity: Name: NameFull: Shirinifard A – PersonEntity: Name: NameFull: Chapple RH – PersonEntity: Name: NameFull: Shen A – PersonEntity: Name: NameFull: Clay MR – PersonEntity: Name: NameFull: Tatevossian RG – PersonEntity: Name: NameFull: Reilly C – PersonEntity: Name: NameFull: Patel J – PersonEntity: Name: NameFull: Lupo M – PersonEntity: Name: NameFull: Cline C – PersonEntity: Name: NameFull: Dionne D – PersonEntity: Name: NameFull: Porter CBM – PersonEntity: Name: NameFull: Waldman J – PersonEntity: Name: NameFull: Bai Y – PersonEntity: Name: NameFull: Zhu B – PersonEntity: Name: NameFull: Barrera I – PersonEntity: Name: NameFull: Murray E – PersonEntity: Name: NameFull: Vigneau S – PersonEntity: Name: NameFull: Napolitano S – PersonEntity: Name: NameFull: Wakiro I – PersonEntity: Name: NameFull: Wu J – PersonEntity: Name: NameFull: Grimaldi G – PersonEntity: Name: NameFull: Dellostritto L – PersonEntity: Name: NameFull: Helvie K – PersonEntity: Name: NameFull: Rotem A – PersonEntity: Name: NameFull: Lako A – PersonEntity: Name: NameFull: Cullen N – PersonEntity: Name: NameFull: Pfaff KL – PersonEntity: Name: NameFull: Karlström Å – PersonEntity: Name: NameFull: Jané-Valbuena J – PersonEntity: Name: NameFull: Todres E – PersonEntity: Name: NameFull: Thorner A – PersonEntity: Name: NameFull: Geeleher P – PersonEntity: Name: NameFull: Rodig SJ – PersonEntity: Name: NameFull: Zhou X – PersonEntity: Name: NameFull: Stewart E – PersonEntity: Name: NameFull: Johnson BE – PersonEntity: Name: NameFull: Wu G – PersonEntity: Name: NameFull: Chen F – PersonEntity: Name: NameFull: Yu J – PersonEntity: Name: NameFull: Goltsev Y – PersonEntity: Name: NameFull: Nolan GP – PersonEntity: Name: NameFull: Rozenblatt-Rosen O – PersonEntity: Name: NameFull: Regev A – PersonEntity: Name: NameFull: Dyer MA IsPartOfRelationships: – BibEntity: Dates: – D: 16 M: 01 Text: 2024 Jan 16 Type: published Y: 2024 Identifiers: – Type: issn-electronic Value: 2692-8205 Titles: – TitleFull: BioRxiv : the preprint server for biology Type: main |
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