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Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial.

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Title: Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial.
Authors: Datoo MS; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Dicko A; Clinical Research Unit of Bougouni-Ouelessebougou, Malaria Research and Training Centre, University of Sciences, Techniques, and Technologies of Bamako, Bamako, Mali., Tinto H; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Ouédraogo JB; Institut des Sciences et Techniques (INSTech), Bobo-Dioulasso, Burkina Faso., Hamaluba M; Kenya Medical Research Institute Centre for Geographical Medicine Research-Coast (KEMRI-CGMRC), Kilifi, Kenya; Centre for Tropical Medicine & Global Health, Nuffield Department of Medicine, Oxford, UK., Olotu A; Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania., Beaumont E; London School of Hygiene and Tropical Medicine, London, UK., Ramos Lopez F; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Natama HM; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Weston S; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Chemba M; Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania., Compaore YD; Institut des Sciences et Techniques (INSTech), Bobo-Dioulasso, Burkina Faso., Issiaka D; Clinical Research Unit of Bougouni-Ouelessebougou, Malaria Research and Training Centre, University of Sciences, Techniques, and Technologies of Bamako, Bamako, Mali., Salou D; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Some AM; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Omenda S; Kenya Medical Research Institute Centre for Geographical Medicine Research-Coast (KEMRI-CGMRC), Kilifi, Kenya., Lawrie A; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Bejon P; Kenya Medical Research Institute Centre for Geographical Medicine Research-Coast (KEMRI-CGMRC), Kilifi, Kenya., Rao H; Serum Institute of India, Pune, India., Chandramohan D; London School of Hygiene and Tropical Medicine, London, UK., Roberts R; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Bharati S; Serum Institute of India, Pune, India., Stockdale L; The Jenner Institute Laboratories, University of Oxford, Oxford, UK., Gairola S; Serum Institute of India, Pune, India., Greenwood BM; London School of Hygiene and Tropical Medicine, London, UK., Ewer KJ; The Jenner Institute Laboratories, University of Oxford, Oxford, UK., Bradley J; London School of Hygiene and Tropical Medicine, London, UK., Kulkarni PS; Serum Institute of India, Pune, India., Shaligram U; Serum Institute of India, Pune, India., Hill AVS; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK; The Jenner Institute Laboratories, University of Oxford, Oxford, UK. Electronic address: adrian.hill@ndm.ox.ac.uk.
Corporate Authors: R21/Matrix-M Phase 3 Trial Group
Source: Lancet (London, England) [Lancet] 2024 Feb 10; Vol. 403 (10426), pp. 533-544. Date of Electronic Publication: 2024 Feb 01.
Publication Type: Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase III; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE
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  Data: Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial.
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  Data: <searchLink fieldCode="AU" term="%22Datoo+MS%22">Datoo MS</searchLink>; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Dicko+A%22">Dicko A</searchLink>; Clinical Research Unit of Bougouni-Ouelessebougou, Malaria Research and Training Centre, University of Sciences, Techniques, and Technologies of Bamako, Bamako, Mali.<br /><searchLink fieldCode="AU" term="%22Tinto+H%22">Tinto H</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Ouédraogo+JB%22">Ouédraogo JB</searchLink>; Institut des Sciences et Techniques (INSTech), Bobo-Dioulasso, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Hamaluba+M%22">Hamaluba M</searchLink>; Kenya Medical Research Institute Centre for Geographical Medicine Research-Coast (KEMRI-CGMRC), Kilifi, Kenya; Centre for Tropical Medicine & Global Health, Nuffield Department of Medicine, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Olotu+A%22">Olotu A</searchLink>; Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania.<br /><searchLink fieldCode="AU" term="%22Beaumont+E%22">Beaumont E</searchLink>; London School of Hygiene and Tropical Medicine, London, UK.<br /><searchLink fieldCode="AU" term="%22Ramos+Lopez+F%22">Ramos Lopez F</searchLink>; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Natama+HM%22">Natama HM</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Weston+S%22">Weston S</searchLink>; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Chemba+M%22">Chemba M</searchLink>; Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania.<br /><searchLink fieldCode="AU" term="%22Compaore+YD%22">Compaore YD</searchLink>; Institut des Sciences et Techniques (INSTech), Bobo-Dioulasso, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Issiaka+D%22">Issiaka D</searchLink>; Clinical Research Unit of Bougouni-Ouelessebougou, Malaria Research and Training Centre, University of Sciences, Techniques, and Technologies of Bamako, Bamako, Mali.<br /><searchLink fieldCode="AU" term="%22Salou+D%22">Salou D</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Some+AM%22">Some AM</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Omenda+S%22">Omenda S</searchLink>; Kenya Medical Research Institute Centre for Geographical Medicine Research-Coast (KEMRI-CGMRC), Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Lawrie+A%22">Lawrie A</searchLink>; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Bejon+P%22">Bejon P</searchLink>; Kenya Medical Research Institute Centre for Geographical Medicine Research-Coast (KEMRI-CGMRC), Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Rao+H%22">Rao H</searchLink>; Serum Institute of India, Pune, India.<br /><searchLink fieldCode="AU" term="%22Chandramohan+D%22">Chandramohan D</searchLink>; London School of Hygiene and Tropical Medicine, London, UK.<br /><searchLink fieldCode="AU" term="%22Roberts+R%22">Roberts R</searchLink>; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Bharati+S%22">Bharati S</searchLink>; Serum Institute of India, Pune, India.<br /><searchLink fieldCode="AU" term="%22Stockdale+L%22">Stockdale L</searchLink>; The Jenner Institute Laboratories, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Gairola+S%22">Gairola S</searchLink>; Serum Institute of India, Pune, India.<br /><searchLink fieldCode="AU" term="%22Greenwood+BM%22">Greenwood BM</searchLink>; London School of Hygiene and Tropical Medicine, London, UK.<br /><searchLink fieldCode="AU" term="%22Ewer+KJ%22">Ewer KJ</searchLink>; The Jenner Institute Laboratories, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Bradley+J%22">Bradley J</searchLink>; London School of Hygiene and Tropical Medicine, London, UK.<br /><searchLink fieldCode="AU" term="%22Kulkarni+PS%22">Kulkarni PS</searchLink>; Serum Institute of India, Pune, India.<br /><searchLink fieldCode="AU" term="%22Shaligram+U%22">Shaligram U</searchLink>; Serum Institute of India, Pune, India.<br /><searchLink fieldCode="AU" term="%22Hill+AVS%22">Hill AVS</searchLink>; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK; The Jenner Institute Laboratories, University of Oxford, Oxford, UK. Electronic address: adrian.hill@ndm.ox.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%222985213R%22">Lancet (London, England)</searchLink> [Lancet] 2024 Feb 10; Vol. 403 (10426), pp. 533-544. <i>Date of Electronic Publication: </i>2024 Feb 01.
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