Targeting DNA2 overcomes metabolic reprogramming in multiple myeloma.

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Title: Targeting DNA2 overcomes metabolic reprogramming in multiple myeloma.
Authors: Thongon N; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ma F; Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA., Baran N; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lockyer P; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Liu J; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Jackson C; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Rose A; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Furudate K; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wildeman B; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Marchesini M; IRCCS Instituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori, Meldola, Italy., Marchica V; Department of Medicine and Surgery, University of Parma, Parma, Italy., Storti P; Department of Medicine and Surgery, University of Parma, Parma, Italy., Todaro G; Department of Medicine and Surgery, University of Parma, Parma, Italy., Ganan-Gomez I; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Adema V; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Rodriguez-Sevilla JJ; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Qing Y; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ha MJ; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Fonseca R; Department of Medicine, Mayo Clinic, Scottsdale, AZ, USA., Stein C; Department of Medicine, Mayo Clinic, Scottsdale, AZ, USA., Class C; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Butler University, Indianapolis, IN, USA., Tan L; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Attanasio S; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Garcia-Manero G; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Giuliani N; Department of Medicine and Surgery, University of Parma, Parma, Italy., Berrios Nolasco D; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Santoni A; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Cerchione C; IRCCS Instituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori, Meldola, Italy., Bueso-Ramos C; Department of Hemopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Konopleva M; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lorenzi P; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Takahashi K; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Manasanch E; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Sammarelli G; Department of Medicine and Surgery, University of Parma, Parma, Italy., Kanagal-Shamanna R; Department of Hemopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Viale A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chesi M; Department of Medicine, Mayo Clinic, Scottsdale, AZ, USA., Colla S; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. scolla@mdanderson.org.
Source: Nature communications [Nat Commun] 2024 Feb 08; Vol. 15 (1), pp. 1203. Date of Electronic Publication: 2024 Feb 08.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Targeting DNA2 overcomes metabolic reprogramming in multiple myeloma.
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  Data: <searchLink fieldCode="AU" term="%22Thongon+N%22">Thongon N</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ma+F%22">Ma F</searchLink>; Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Baran+N%22">Baran N</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Lockyer+P%22">Lockyer P</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Jackson+C%22">Jackson C</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Rose+A%22">Rose A</searchLink>; 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Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Adema+V%22">Adema V</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Sevilla+JJ%22">Rodriguez-Sevilla JJ</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Qing+Y%22">Qing Y</searchLink>; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ha+MJ%22">Ha MJ</searchLink>; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Fonseca+R%22">Fonseca R</searchLink>; Department of Medicine, Mayo Clinic, Scottsdale, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Stein+C%22">Stein C</searchLink>; Department of Medicine, Mayo Clinic, Scottsdale, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Class+C%22">Class C</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Butler University, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Tan+L%22">Tan L</searchLink>; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Attanasio+S%22">Attanasio S</searchLink>; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Garcia-Manero+G%22">Garcia-Manero G</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Giuliani+N%22">Giuliani N</searchLink>; Department of Medicine and Surgery, University of Parma, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Berrios+Nolasco+D%22">Berrios Nolasco D</searchLink>; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Santoni+A%22">Santoni A</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Cerchione+C%22">Cerchione C</searchLink>; IRCCS Instituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori, Meldola, Italy.<br /><searchLink fieldCode="AU" term="%22Bueso-Ramos+C%22">Bueso-Ramos C</searchLink>; Department of Hemopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Konopleva+M%22">Konopleva M</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Lorenzi+P%22">Lorenzi P</searchLink>; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Takahashi+K%22">Takahashi K</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Manasanch+E%22">Manasanch E</searchLink>; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Sammarelli+G%22">Sammarelli G</searchLink>; Department of Medicine and Surgery, University of Parma, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Kanagal-Shamanna+R%22">Kanagal-Shamanna R</searchLink>; Department of Hemopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Viale+A%22">Viale A</searchLink>; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Chesi+M%22">Chesi M</searchLink>; Department of Medicine, Mayo Clinic, Scottsdale, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Colla+S%22">Colla S</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. scolla@mdanderson.org.
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