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Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations.

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Title: Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations.
Authors: Lennon NJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA. nlennon@broadinstitute.org., Kottyan LC; Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA., Kachulis C; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Abul-Husn NS; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Arias J; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Belbin G; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Below JE; Vanderbilt University Medical Center, Nashville, TN, USA., Berndt SI; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Chung WK; Columbia University, New York, NY, USA., Cimino JJ; University of Alabama at Birmingham, Birmingham, AL, USA., Clayton EW; Vanderbilt University Medical Center, Nashville, TN, USA., Connolly JJ; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Crosslin DR; Tulane University, New Orleans, LA, USA.; University of Washington, Seattle, WA, USA., Dikilitas O; Mayo Clinic, Rochester, MI, USA., Velez Edwards DR; Vanderbilt University Medical Center, Nashville, TN, USA., Feng Q; Vanderbilt University Medical Center, Nashville, TN, USA., Fisher M; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Freimuth RR; Mayo Clinic, Rochester, MI, USA., Ge T; Mass General Brigham, Boston, MA, USA., Glessner JT; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Gordon AS; Northwestern University, Evanston, IL, USA., Patterson C; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hakonarson H; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Harden M; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Harr M; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Hirschhorn JN; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Boston Children's Hospital, Boston, MA, USA., Hoggart C; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hsu L; Fred Hutchinson Cancer Center, Seattle, WA, USA., Irvin MR; University of Alabama at Birmingham, Birmingham, AL, USA., Jarvik GP; University of Washington, Seattle, WA, USA., Karlson EW; Mass General Brigham, Boston, MA, USA., Khan A; Columbia University, New York, NY, USA., Khera A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kiryluk K; Columbia University, New York, NY, USA., Kullo I; Mayo Clinic, Rochester, MI, USA., Larkin K; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Limdi N; University of Alabama at Birmingham, Birmingham, AL, USA., Linder JE; Vanderbilt University Medical Center, Nashville, TN, USA., Loos RJF; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Luo Y; Northwestern University, Evanston, IL, USA., Malolepsza E; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Manolio TA; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Martin LJ; Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA., McCarthy L; Broad Institute of MIT and Harvard, Cambridge, MA, USA., McNally EM; Northwestern University, Evanston, IL, USA., Meigs JB; Mass General Brigham, Boston, MA, USA., Mersha TB; Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA., Mosley JD; Vanderbilt University Medical Center, Nashville, TN, USA., Musick A; National Institutes of Health, Bethesda, MD, USA., Namjou B; Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA., Pai N; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Pesce LL; Northwestern University, Evanston, IL, USA., Peters U; Fred Hutchinson Cancer Center, Seattle, WA, USA., Peterson JF; Vanderbilt University Medical Center, Nashville, TN, USA., Prows CA; Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA., Puckelwartz MJ; Northwestern University, Evanston, IL, USA., Rehm HL; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Roden DM; Vanderbilt University Medical Center, Nashville, TN, USA., Rosenthal EA; University of Washington, Seattle, WA, USA., Rowley R; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Sawicki KT; Northwestern University, Evanston, IL, USA., Schaid DJ; Mayo Clinic, Rochester, MI, USA., Smit RAJ; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Smith JL; Mayo Clinic, Rochester, MI, USA., Smoller JW; Mass General Brigham, Boston, MA, USA., Thomas M; Fred Hutchinson Cancer Center, Seattle, WA, USA., Tiwari H; University of Alabama at Birmingham, Birmingham, AL, USA., Toledo DM; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Vaitinadin NS; Vanderbilt University Medical Center, Nashville, TN, USA., Veenstra D; University of Washington, Seattle, WA, USA., Walunas TL; Northwestern University, Evanston, IL, USA., Wang Z; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wei WQ; Vanderbilt University Medical Center, Nashville, TN, USA., Weng C; Columbia University, New York, NY, USA., Wiesner GL; Vanderbilt University Medical Center, Nashville, TN, USA., Yin X; Nanjing Medical University, Nanjing, China., Kenny EE; Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Corporate Authors: GIANT Consortium, All of Us Research Program
Source: Nature medicine [Nat Med] 2024 Feb; Vol. 30 (2), pp. 480-487. Date of Electronic Publication: 2024 Feb 19.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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            NameFull: Peters U
      – PersonEntity:
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            NameFull: Thomas M
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            NameFull: Tiwari H
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            NameFull: Vaitinadin NS
      – PersonEntity:
          Name:
            NameFull: Veenstra D
      – PersonEntity:
          Name:
            NameFull: Walunas TL
      – PersonEntity:
          Name:
            NameFull: Wang Z
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      – PersonEntity:
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          Dates:
            – D: 01
              M: 02
              Text: 2024 Feb
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-electronic
              Value: 1546-170X
          Numbering:
            – Type: volume
              Value: 30
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Nature medicine
              Type: main
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