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Intracellular proteomics and extracellular vesiculomics as a metric of disease recapitulation in 3D-bioprinted aortic valve arrays.

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Title: Intracellular proteomics and extracellular vesiculomics as a metric of disease recapitulation in 3D-bioprinted aortic valve arrays.
Authors: Clift CL; Division of Cardiovascular Medicine, Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Blaser MC; Division of Cardiovascular Medicine, Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Gerrits W; Division of Cardiovascular Medicine, Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Department of Cardiothoracic Surgery, University Medical Center Utrecht, Utrecht, Netherlands., Turner ME; Division of Cardiovascular Medicine, Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Sonawane A; Division of Cardiovascular Medicine, Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Pham T; Division of Cardiovascular Medicine, Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Andresen JL; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Fenton OS; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Grolman JM; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02134, USA.; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA.; Materials Science and Engineering, The Technion-Israel Institute of Technology, Haifa, Israel., Campedelli A; Division of Cardiovascular Medicine, Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Buffolo F; Division of Cardiovascular Medicine, Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Division of Internal Medicine and Hypertension Unite, Department of Medical Sciences, University of Torin, Turin, Italy., Schoen FJ; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Hjortnaes J; Department of Cardiothoracic Surgery, Leiden University Medical Center (LUMC), Leiden, Netherlands., Muehlschlegel JD; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Mooney DJ; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02134, USA.; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA., Aikawa M; Division of Cardiovascular Medicine, Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Division of Cardiovascular Medicine, Department of Medicine, Center for Excellence in Vascular Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Singh SA; Division of Cardiovascular Medicine, Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Langer R; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.; Harvard and MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Aikawa E; Division of Cardiovascular Medicine, Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Division of Cardiovascular Medicine, Department of Medicine, Center for Excellence in Vascular Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Source: Science advances [Sci Adv] 2024 Mar; Vol. 10 (9), pp. eadj9793. Date of Electronic Publication: 2024 Feb 28.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: Intracellular proteomics and extracellular vesiculomics as a metric of disease recapitulation in 3D-bioprinted aortic valve arrays.
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Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02134, USA.; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA.; Materials Science and Engineering, The Technion-Israel Institute of Technology, Haifa, Israel.<br /><searchLink fieldCode="AU" term="%22Campedelli+A%22">Campedelli A</searchLink>; Division of Cardiovascular Medicine, Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Buffolo+F%22">Buffolo F</searchLink>; Division of Cardiovascular Medicine, Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Division of Internal Medicine and Hypertension Unite, Department of Medical Sciences, University of Torin, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Schoen+FJ%22">Schoen FJ</searchLink>; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Hjortnaes+J%22">Hjortnaes J</searchLink>; Department of Cardiothoracic Surgery, Leiden University Medical Center (LUMC), Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Muehlschlegel+JD%22">Muehlschlegel JD</searchLink>; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Mooney+DJ%22">Mooney DJ</searchLink>; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02134, USA.; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Aikawa+M%22">Aikawa M</searchLink>; Division of Cardiovascular Medicine, Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Division of Cardiovascular Medicine, Department of Medicine, Center for Excellence in Vascular Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Singh+SA%22">Singh SA</searchLink>; Division of Cardiovascular Medicine, Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Langer+R%22">Langer R</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.; Harvard and MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Aikawa+E%22">Aikawa E</searchLink>; Division of Cardiovascular Medicine, Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Division of Cardiovascular Medicine, Department of Medicine, Center for Excellence in Vascular Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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