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Opportunistic dried blood spot sampling validates and optimizes a pediatric population pharmacokinetic model of metronidazole.

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Title: Opportunistic dried blood spot sampling validates and optimizes a pediatric population pharmacokinetic model of metronidazole.
Authors: Randell RL; Department of Pediatrics, Duke University, Durham, North Carolina, USA.; Duke Clinical Research Institute, Durham, North Carolina, USA., Balevic SJ; Department of Pediatrics, Duke University, Durham, North Carolina, USA.; Duke Clinical Research Institute, Durham, North Carolina, USA., Greenberg RG; Department of Pediatrics, Duke University, Durham, North Carolina, USA.; Duke Clinical Research Institute, Durham, North Carolina, USA., Cohen-Wolkowiez M; Department of Pediatrics, Duke University, Durham, North Carolina, USA.; Duke Clinical Research Institute, Durham, North Carolina, USA., Thompson EJ; Department of Pediatrics, Duke University, Durham, North Carolina, USA.; Duke Clinical Research Institute, Durham, North Carolina, USA., Venkatachalam S; Duke Clinical Research Institute, Durham, North Carolina, USA., Smith MJ; Department of Pediatrics, Duke University, Durham, North Carolina, USA., Bendel C; Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Bliss JM; Department of Pediatrics, University of Rochester Medical Center, Rochester, New York, USA., Chaaban H; Division of Neonatology, Department of Pediatrics, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma, USA., Chhabra R; Division of Neonatology, Department of Pediatrics, Hackensack University Medical Center, Hackensack, New Jersey, USA., Dammann CEL; Department of Pediatrics, Tufts Medical Center, Tufts University, Boston, Massachusetts, USA., Downey LC; Department of Pediatrics, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA., Hornik C; Department of Pediatrics, Duke University, Durham, North Carolina, USA.; Duke Clinical Research Institute, Durham, North Carolina, USA., Hussain N; Division of Neonatology, Department of Pediatrics, Connecticut Children's, Hartford, Connecticut, USA., Laughon MM; Department of Pediatrics, Division of Neonatal-Perinatal Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Lavery A; Loma Linda University, Loma Linda, California, USA., Moya F; Division of Wilmington Pediatric Specialties, Department of Pediatrics, UNC School of Medicine, Chapel Hill, North Carolina, USA., Saxonhouse M; Division of Neonatology, Department of Pediatrics, Levine Children's Hospital, Wake Forest School of Medicine, Charlotte campus, Atrium Healthcare, Charlotte, North Carolina, USA., Sokol GM; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Trembath A; Division of Neonatal-Perinatal Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Weitkamp J-H; Mildred Stahlman Division of Neonatology, Monroe Carell Jr. Children's Hospital at Vanderbilt, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Hornik CP; Department of Pediatrics, Duke University, Durham, North Carolina, USA.; Duke Clinical Research Institute, Durham, North Carolina, USA.
Corporate Authors: Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee
Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2024 Apr 03; Vol. 68 (4), pp. e0153323. Date of Electronic Publication: 2024 Mar 14.
Publication Type: Clinical Trial, Phase I; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Validation Study
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Opportunistic dried blood spot sampling validates and optimizes a pediatric population pharmacokinetic model of metronidazole.
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  Data: <searchLink fieldCode="AU" term="%22Randell+RL%22">Randell RL</searchLink>; Department of Pediatrics, Duke University, Durham, North Carolina, USA.; Duke Clinical Research Institute, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Balevic+SJ%22">Balevic SJ</searchLink>; Department of Pediatrics, Duke University, Durham, North Carolina, USA.; Duke Clinical Research Institute, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Greenberg+RG%22">Greenberg RG</searchLink>; Department of Pediatrics, Duke University, Durham, North Carolina, USA.; Duke Clinical Research Institute, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Cohen-Wolkowiez+M%22">Cohen-Wolkowiez M</searchLink>; Department of Pediatrics, Duke University, Durham, North Carolina, USA.; Duke Clinical Research Institute, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Thompson+EJ%22">Thompson EJ</searchLink>; Department of Pediatrics, Duke University, Durham, North Carolina, USA.; Duke Clinical Research Institute, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Venkatachalam+S%22">Venkatachalam S</searchLink>; Duke Clinical Research Institute, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Smith+MJ%22">Smith MJ</searchLink>; Department of Pediatrics, Duke University, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Bendel+C%22">Bendel C</searchLink>; Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Bliss+JM%22">Bliss JM</searchLink>; Department of Pediatrics, University of Rochester Medical Center, Rochester, New York, USA.<br /><searchLink fieldCode="AU" term="%22Chaaban+H%22">Chaaban H</searchLink>; Division of Neonatology, Department of Pediatrics, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Chhabra+R%22">Chhabra R</searchLink>; Division of Neonatology, Department of Pediatrics, Hackensack University Medical Center, Hackensack, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Dammann+CEL%22">Dammann CEL</searchLink>; Department of Pediatrics, Tufts Medical Center, Tufts University, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Downey+LC%22">Downey LC</searchLink>; Department of Pediatrics, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Hornik+C%22">Hornik C</searchLink>; Department of Pediatrics, Duke University, Durham, North Carolina, USA.; Duke Clinical Research Institute, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Hussain+N%22">Hussain N</searchLink>; Division of Neonatology, Department of Pediatrics, Connecticut Children's, Hartford, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Laughon+MM%22">Laughon MM</searchLink>; Department of Pediatrics, Division of Neonatal-Perinatal Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Lavery+A%22">Lavery A</searchLink>; Loma Linda University, Loma Linda, California, USA.<br /><searchLink fieldCode="AU" term="%22Moya+F%22">Moya F</searchLink>; Division of Wilmington Pediatric Specialties, Department of Pediatrics, UNC School of Medicine, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Saxonhouse+M%22">Saxonhouse M</searchLink>; Division of Neonatology, Department of Pediatrics, Levine Children's Hospital, Wake Forest School of Medicine, Charlotte campus, Atrium Healthcare, Charlotte, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Sokol+GM%22">Sokol GM</searchLink>; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Trembath+A%22">Trembath A</searchLink>; Division of Neonatal-Perinatal Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Weitkamp+J-H%22">Weitkamp J-H</searchLink>; Mildred Stahlman Division of Neonatology, Monroe Carell Jr. Children's Hospital at Vanderbilt, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Hornik+CP%22">Hornik CP</searchLink>; Department of Pediatrics, Duke University, Durham, North Carolina, USA.; Duke Clinical Research Institute, Durham, North Carolina, USA.
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  Data: <searchLink fieldCode="JN" term="%220315061%22">Antimicrobial agents and chemotherapy</searchLink> [Antimicrob Agents Chemother] 2024 Apr 03; Vol. 68 (4), pp. e0153323. <i>Date of Electronic Publication: </i>2024 Mar 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Microbiology%22">American Society for Microbiology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0315061 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1098-6596 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200664804%22">00664804 </searchLink><i>NLM ISO Abbreviation: </i>Antimicrob Agents Chemother <i>Subsets: </i>MEDLINE
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              Text: 2024 Apr 03
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