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Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets.

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Title: Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets.
Authors: Xu X; Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK., Khunsriraksakul C; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA., Eales JM; Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK., Rubin S; Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK., Scannali D; Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK., Saluja S; Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK., Talavera D; Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK., Markus H; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA., Wang L; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA., Drzal M; Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK., Maan A; Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK., Lay AC; Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK., Prestes PR; Health Innovation and Transformation Centre, Federation University Australia, Ballarat, Australia., Regan J; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA., Diwadkar AR; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA., Denniff M; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK., Rempega G; Department of Urology, Medical University of Silesia, Katowice, Poland., Ryszawy J; Department of Urology, Medical University of Silesia, Katowice, Poland., Król R; Department of General, Vascular and Transplant Surgery, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland., Dormer JP; Department of Cellular Pathology, University Hospitals of Leicester, Leicester, UK., Szulinska M; Department of Obesity, Metabolic Disorders Treatment and Clinical Dietetics, Karol Marcinkowski University of Medical Sciences, Poznan, Poland., Walczak M; Department of Internal Diseases, Metabolic Disorders and Arterial Hypertension, Poznan University of Medical Sciences, Poznan, Poland., Antczak A; Department of Urology and Uro-oncology, Karol Marcinkowski University of Medical Sciences, Poznan, Poland., Matías-García PR; Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany.; Research Unit Molecular Epidemiology, Helmholtz Center Munich, Neuherberg, Germany.; German Research Center for Cardiovascular Disease (DZHK), partner site Munich Heart Alliance, Munich, Germany., Waldenberger M; Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany.; Research Unit Molecular Epidemiology, Helmholtz Center Munich, Neuherberg, Germany.; German Research Center for Cardiovascular Disease (DZHK), partner site Munich Heart Alliance, Munich, Germany., Woolf AS; Division of Cell Matrix Biology and Regenerative Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Royal Manchester Children's Hospital and Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, UK., Keavney B; Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK.; Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust Manchester, Manchester Royal Infirmary, Manchester, UK., Zukowska-Szczechowska E; Department of Health Care, Silesian Medical College, Katowice, Poland., Wystrychowski W; Department of General, Vascular and Transplant Surgery, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland., Zywiec J; Department of Internal Medicine, Diabetology and Nephrology, Zabrze, Medical University of Silesia, Katowice, Poland., Bogdanski P; Department of Obesity, Metabolic Disorders Treatment and Clinical Dietetics, Karol Marcinkowski University of Medical Sciences, Poznan, Poland., Danser AHJ; Department of Internal Medicine, Division of Pharmacology and Vascular Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Guzik TJ; Department of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland.; Centre for Cardiovascular Sciences, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.; Center for Medical Genomics OMICRON, Jagiellonian University Medical College, Kraków, Poland., Morris AP; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal & Dermatological Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK., Liu DJ; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA., Charchar FJ; Health Innovation and Transformation Centre, Federation University Australia, Ballarat, Australia.; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; Department of Physiology, University of Melbourne, Melbourne, Australia., Tomaszewski M; Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK. maciej.tomaszewski@manchester.ac.uk.; Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust Manchester, Manchester Royal Infirmary, Manchester, UK. maciej.tomaszewski@manchester.ac.uk.
Corporate Authors: Human Kidney Tissue Resource Study Group
Source: Nature communications [Nat Commun] 2024 Mar 19; Vol. 15 (1), pp. 2359. Date of Electronic Publication: 2024 Mar 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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