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Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals.

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Title: Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals.
Authors: Pérez-Vargas J; Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada., Lemieux G; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada., Thompson CAH; Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada., Désilets A; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada., Ennis S; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada., Gao G; Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada; Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada., Gordon DG; Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada., Schulz AL; Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada., Niikura M; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada., Nabi IR; Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada., Krajden M; British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, BC, V5Z 4R4, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada., Boudreault PL; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada., Leduc R; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada. Electronic address: richard.leduc@usherbrooke.ca., Jean F; Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada. Electronic address: fjean@mail.ubc.ca.
Source: Antiviral research [Antiviral Res] 2024 May; Vol. 225, pp. 105869. Date of Electronic Publication: 2024 Mar 26.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8109699 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9096 (Electronic) Linking ISSN: 01663542 NLM ISO Abbreviation: Antiviral Res Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Pérez-Vargas+J%22">Pérez-Vargas J</searchLink>; Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Lemieux+G%22">Lemieux G</searchLink>; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Thompson+CAH%22">Thompson CAH</searchLink>; Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Désilets+A%22">Désilets A</searchLink>; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Ennis+S%22">Ennis S</searchLink>; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Gao+G%22">Gao G</searchLink>; Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada; Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Gordon+DG%22">Gordon DG</searchLink>; Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Schulz+AL%22">Schulz AL</searchLink>; Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Niikura+M%22">Niikura M</searchLink>; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Nabi+IR%22">Nabi IR</searchLink>; Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Krajden+M%22">Krajden M</searchLink>; British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, BC, V5Z 4R4, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.<br /><searchLink fieldCode="AU" term="%22Boudreault+PL%22">Boudreault PL</searchLink>; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Leduc+R%22">Leduc R</searchLink>; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada. Electronic address: richard.leduc@usherbrooke.ca.<br /><searchLink fieldCode="AU" term="%22Jean+F%22">Jean F</searchLink>; Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada. Electronic address: fjean@mail.ubc.ca.
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