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The CHK1 inhibitor prexasertib in BRCA wild-type platinum-resistant recurrent high-grade serous ovarian carcinoma: a phase 2 trial.

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Title: The CHK1 inhibitor prexasertib in BRCA wild-type platinum-resistant recurrent high-grade serous ovarian carcinoma: a phase 2 trial.
Authors: Giudice E; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.; Institute of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, 00168, Rome, Italy., Huang TT; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, 20892, USA., Nair JR; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, 20892, USA., Zurcher G; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, 20892, USA., McCoy A; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, 20892, USA., Nousome D; Center for Cancer Research Collaborative Bioinformatics Resource, CCR, NCI, NIH, Bethesda, MD, 20892, USA., Radke MR; Department of Ob/Gyn, University of Washington, Seattle, WA, 98195, USA., Swisher EM; Department of Ob/Gyn, University of Washington, Seattle, WA, 98195, USA., Lipkowitz S; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, 20892, USA., Ibanez K; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, 20892, USA., Donohue D; Statistical Consulting and Scientific Programming Group, Computer and Statistical Services, Data Management Services, Inc. (a BRMI company), NCI, Frederick, MD, 21702, USA., Malys T; Statistical Consulting and Scientific Programming Group, Computer and Statistical Services, Data Management Services, Inc. (a BRMI company), NCI, Frederick, MD, 21702, USA., Lee MJ; Developmental Therapeutics Branch, CCR, NCI, NIH, Bethesda, MD, 20892, USA., Redd B; Clinical Image Processing Service, Department of Radiology and Imaging Sciences, CCR, NCI, NIH, Bethesda, MD, 20892, USA., Levy E; Interventional Radiology, CCR, NCI, NIH, Bethesda, MD, 20892, USA., Rastogi S; Developmental Therapeutics Branch, CCR, NCI, NIH, Bethesda, MD, 20892, USA., Sato N; Developmental Therapeutics Branch, CCR, NCI, NIH, Bethesda, MD, 20892, USA., Trepel JB; Developmental Therapeutics Branch, CCR, NCI, NIH, Bethesda, MD, 20892, USA., Lee JM; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, 20892, USA. leej6@mail.nih.gov.
Source: Nature communications [Nat Commun] 2024 Mar 30; Vol. 15 (1), pp. 2805. Date of Electronic Publication: 2024 Mar 30.
Publication Type: Clinical Trial, Phase II; Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: The CHK1 inhibitor prexasertib in BRCA wild-type platinum-resistant recurrent high-grade serous ovarian carcinoma: a phase 2 trial.
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  Data: <searchLink fieldCode="AU" term="%22Giudice+E%22">Giudice E</searchLink>; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.; Institute of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, 00168, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Huang+TT%22">Huang TT</searchLink>; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Nair+JR%22">Nair JR</searchLink>; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Zurcher+G%22">Zurcher G</searchLink>; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22McCoy+A%22">McCoy A</searchLink>; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Nousome+D%22">Nousome D</searchLink>; Center for Cancer Research Collaborative Bioinformatics Resource, CCR, NCI, NIH, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Radke+MR%22">Radke MR</searchLink>; Department of Ob/Gyn, University of Washington, Seattle, WA, 98195, USA.<br /><searchLink fieldCode="AU" term="%22Swisher+EM%22">Swisher EM</searchLink>; Department of Ob/Gyn, University of Washington, Seattle, WA, 98195, USA.<br /><searchLink fieldCode="AU" term="%22Lipkowitz+S%22">Lipkowitz S</searchLink>; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Ibanez+K%22">Ibanez K</searchLink>; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Donohue+D%22">Donohue D</searchLink>; Statistical Consulting and Scientific Programming Group, Computer and Statistical Services, Data Management Services, Inc. (a BRMI company), NCI, Frederick, MD, 21702, USA.<br /><searchLink fieldCode="AU" term="%22Malys+T%22">Malys T</searchLink>; Statistical Consulting and Scientific Programming Group, Computer and Statistical Services, Data Management Services, Inc. (a BRMI company), NCI, Frederick, MD, 21702, USA.<br /><searchLink fieldCode="AU" term="%22Lee+MJ%22">Lee MJ</searchLink>; Developmental Therapeutics Branch, CCR, NCI, NIH, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Redd+B%22">Redd B</searchLink>; Clinical Image Processing Service, Department of Radiology and Imaging Sciences, CCR, NCI, NIH, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Levy+E%22">Levy E</searchLink>; Interventional Radiology, CCR, NCI, NIH, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Rastogi+S%22">Rastogi S</searchLink>; Developmental Therapeutics Branch, CCR, NCI, NIH, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Sato+N%22">Sato N</searchLink>; Developmental Therapeutics Branch, CCR, NCI, NIH, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Trepel+JB%22">Trepel JB</searchLink>; Developmental Therapeutics Branch, CCR, NCI, NIH, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Lee+JM%22">Lee JM</searchLink>; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, 20892, USA. leej6@mail.nih.gov.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2024 Mar 30; Vol. 15 (1), pp. 2805. <i>Date of Electronic Publication: </i>2024 Mar 30.
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