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PCSK9 stimulates Syk, PKCδ, and NF-κB, leading to atherosclerosis progression independently of LDL receptor.

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Title: PCSK9 stimulates Syk, PKCδ, and NF-κB, leading to atherosclerosis progression independently of LDL receptor.
Authors: Shin D; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea., Kim S; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea., Lee H; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea., Lee HC; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea., Lee J; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea., Park HW; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Program in Stem Cell Biology, Seoul National University College of Medicine, Seoul, Republic of Korea., Fukai M; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea., Choi E; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea., Choi S; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea., Koo BJ; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea., Yu JH; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea., No G; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea., Cho S; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Program in Stem Cell Biology, Seoul National University College of Medicine, Seoul, Republic of Korea., Kim CW; Department of Preclinical Trial, Laboratory Animal Center, Osong Medical Innovation Foundation (KBIO), Cheongju, Chungbuk, Republic of Korea., Han D; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea., Jang HD; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea. 65765@snuh.org.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea. 65765@snuh.org., Kim HS; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea. hyosoo@snu.ac.kr.; Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea. hyosoo@snu.ac.kr.; Program in Stem Cell Biology, Seoul National University College of Medicine, Seoul, Republic of Korea. hyosoo@snu.ac.kr.; Cardiovascular Center & Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea. hyosoo@snu.ac.kr.
Source: Nature communications [Nat Commun] 2024 Mar 30; Vol. 15 (1), pp. 2789. Date of Electronic Publication: 2024 Mar 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: PCSK9 stimulates Syk, PKCδ, and NF-κB, leading to atherosclerosis progression independently of LDL receptor.
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  Data: <searchLink fieldCode="AU" term="%22Shin+D%22">Shin D</searchLink>; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+S%22">Kim S</searchLink>; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+H%22">Lee H</searchLink>; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+HC%22">Lee HC</searchLink>; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+HW%22">Park HW</searchLink>; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Program in Stem Cell Biology, Seoul National University College of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Fukai+M%22">Fukai M</searchLink>; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+E%22">Choi E</searchLink>; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+S%22">Choi S</searchLink>; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Koo+BJ%22">Koo BJ</searchLink>; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yu+JH%22">Yu JH</searchLink>; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22No+G%22">No G</searchLink>; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Cho+S%22">Cho S</searchLink>; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Program in Stem Cell Biology, Seoul National University College of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+CW%22">Kim CW</searchLink>; Department of Preclinical Trial, Laboratory Animal Center, Osong Medical Innovation Foundation (KBIO), Cheongju, Chungbuk, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Han+D%22">Han D</searchLink>; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jang+HD%22">Jang HD</searchLink>; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea. 65765@snuh.org.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea. 65765@snuh.org.<br /><searchLink fieldCode="AU" term="%22Kim+HS%22">Kim HS</searchLink>; Center of CBT (Cell and BioTherapy), Seoul National University Hospital, Seoul, Republic of Korea. hyosoo@snu.ac.kr.; Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea. hyosoo@snu.ac.kr.; Program in Stem Cell Biology, Seoul National University College of Medicine, Seoul, Republic of Korea. hyosoo@snu.ac.kr.; Cardiovascular Center & Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea. hyosoo@snu.ac.kr.
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