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Late-stage meta-C-H alkylation of pharmaceuticals to modulate biological properties and expedite molecular optimisation in a single step.

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Title: Late-stage meta-C-H alkylation of pharmaceuticals to modulate biological properties and expedite molecular optimisation in a single step.
Authors: Guillemard L; Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Ackermann L; Institut für Organische und Biomolekulare Chemie and Wöhler Research Institute for Sustainable Chemistry (WISCh), Georg-August-Universität Göttingen, Göttingen, Germany. lutz.ackermann@chemie.uni-goettingen.de.; German Centre for Cardiovascular Research (DZHK), Berlin, Germany. lutz.ackermann@chemie.uni-goettingen.de., Johansson MJ; Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. magnus.j.johansson2@astrazeneca.com.
Source: Nature communications [Nat Commun] 2024 Apr 18; Vol. 15 (1), pp. 3349. Date of Electronic Publication: 2024 Apr 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Guillemard+L%22">Guillemard L</searchLink>; Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Ackermann+L%22">Ackermann L</searchLink>; Institut für Organische und Biomolekulare Chemie and Wöhler Research Institute for Sustainable Chemistry (WISCh), Georg-August-Universität Göttingen, Göttingen, Germany. lutz.ackermann@chemie.uni-goettingen.de.; German Centre for Cardiovascular Research (DZHK), Berlin, Germany. lutz.ackermann@chemie.uni-goettingen.de.<br /><searchLink fieldCode="AU" term="%22Johansson+MJ%22">Johansson MJ</searchLink>; Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. magnus.j.johansson2@astrazeneca.com.
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        Value: 10.1038/s41467-024-46697-8
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