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The translational gap for gene therapies in low- and middle-income countries.

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Title: The translational gap for gene therapies in low- and middle-income countries.
Authors: Doxzen KW; Strategic Analysis Inc., Arlington, VA, USA., Adair JE; Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Departments of Medical Oncology and Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Fonseca Bazzo YM; Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Brasília, Brasília, DF, Brazil., Bukini D; Sickle Cell Programme, Department of Haematology and Blood Transfusion, Muhimbili University of Health & Allied Sciences (MUHAS), Dar-es-Salaam, Tanzania.; SickleInAfrica Clinical Coordinating Center, Muhimbili University of Health & Allied Sciences (MUHAS), Dar-es-Salaam, Tanzania., Cornetta K; Indiana University School of Medicine, Indianapolis, IN, USA., Dalal V; Department of Health Research, Ministry of Health and Family Welfare, Government of India, New Delhi, India., Guerino-Cunha RL; Centro Paulista de Oncologia, Grupo Oncoclínicas, São Paulo, SP, Brazil.; Instituto Oncoclínicas, Rio de Janeiro, RJ, Brazil., Hongeng S; Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Jotwani G; Indian Council of Medical Research, New Delhi, India., Kityo-Mutuluuza C; Joint Clinical Research Centre (JCRC), Kampala, Uganda., Lakshmanan K; Department of Pediatric Hematology and Oncology, Yale School of Medicine, New Haven, CT, USA., Mahlangu J; Department of Molecular Medicine and Haematology, Faculty of Health Sciences, University of the Witwatersrand and NHLS, Johannesburg, South Africa., Makani J; Sickle Cell Programme, Department of Haematology and Blood Transfusion, Muhimbili University of Health & Allied Sciences (MUHAS), Dar-es-Salaam, Tanzania.; SickleInAfrica Clinical Coordinating Center, Muhimbili University of Health & Allied Sciences (MUHAS), Dar-es-Salaam, Tanzania.; Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, UK., Mathews V; Department of Haematology, Christian Medical College (CMC), Vellore, India., Ozelo MC; INCT Hemocentro UNICAMP, Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, SP, Brazil., Rangarajan S; Advanced Center for Oncology, Haematology & Rare Disorders (ACOHRD), K. J. Somaiya Medical College & Research Center, Somaiya Ayurvihar, Mumbai, Maharashtra, India.; Faculty of Medicine, University of Southampton, Southampton, UK., Scholefield J; Bioengineering and Integrated Genomics Group, Next Generation Health Cluster, Council for Scientific and Industrial Research, Pretoria, South Africa.; Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Batista Silva Júnior J; Brazilian Health Regulatory Agency-ANVISA, Brasília, DF, Brazil.; Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Brasília, Brasília, DF, Brazil., McCune JM; HIV Frontiers, Global Health Accelerator, Bill & Melinda Gates Foundation, Seattle, WA, USA.
Source: Science translational medicine [Sci Transl Med] 2024 May 08; Vol. 16 (746), pp. eadn1902. Date of Electronic Publication: 2024 May 08.
Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The translational gap for gene therapies in low- and middle-income countries.
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  Data: <searchLink fieldCode="AU" term="%22Doxzen+KW%22">Doxzen KW</searchLink>; Strategic Analysis Inc., Arlington, VA, USA.<br /><searchLink fieldCode="AU" term="%22Adair+JE%22">Adair JE</searchLink>; Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Departments of Medical Oncology and Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Fonseca+Bazzo+YM%22">Fonseca Bazzo YM</searchLink>; Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Brasília, Brasília, DF, Brazil.<br /><searchLink fieldCode="AU" term="%22Bukini+D%22">Bukini D</searchLink>; Sickle Cell Programme, Department of Haematology and Blood Transfusion, Muhimbili University of Health & Allied Sciences (MUHAS), Dar-es-Salaam, Tanzania.; SickleInAfrica Clinical Coordinating Center, Muhimbili University of Health & Allied Sciences (MUHAS), Dar-es-Salaam, Tanzania.<br /><searchLink fieldCode="AU" term="%22Cornetta+K%22">Cornetta K</searchLink>; Indiana University School of Medicine, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Dalal+V%22">Dalal V</searchLink>; Department of Health Research, Ministry of Health and Family Welfare, Government of India, New Delhi, India.<br /><searchLink fieldCode="AU" term="%22Guerino-Cunha+RL%22">Guerino-Cunha RL</searchLink>; Centro Paulista de Oncologia, Grupo Oncoclínicas, São Paulo, SP, Brazil.; Instituto Oncoclínicas, Rio de Janeiro, RJ, Brazil.<br /><searchLink fieldCode="AU" term="%22Hongeng+S%22">Hongeng S</searchLink>; Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Jotwani+G%22">Jotwani G</searchLink>; Indian Council of Medical Research, New Delhi, India.<br /><searchLink fieldCode="AU" term="%22Kityo-Mutuluuza+C%22">Kityo-Mutuluuza C</searchLink>; Joint Clinical Research Centre (JCRC), Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Lakshmanan+K%22">Lakshmanan K</searchLink>; Department of Pediatric Hematology and Oncology, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Mahlangu+J%22">Mahlangu J</searchLink>; Department of Molecular Medicine and Haematology, Faculty of Health Sciences, University of the Witwatersrand and NHLS, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Makani+J%22">Makani J</searchLink>; Sickle Cell Programme, Department of Haematology and Blood Transfusion, Muhimbili University of Health & Allied Sciences (MUHAS), Dar-es-Salaam, Tanzania.; SickleInAfrica Clinical Coordinating Center, Muhimbili University of Health & Allied Sciences (MUHAS), Dar-es-Salaam, Tanzania.; Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Mathews+V%22">Mathews V</searchLink>; Department of Haematology, Christian Medical College (CMC), Vellore, India.<br /><searchLink fieldCode="AU" term="%22Ozelo+MC%22">Ozelo MC</searchLink>; INCT Hemocentro UNICAMP, Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Rangarajan+S%22">Rangarajan S</searchLink>; Advanced Center for Oncology, Haematology & Rare Disorders (ACOHRD), K. J. Somaiya Medical College & Research Center, Somaiya Ayurvihar, Mumbai, Maharashtra, India.; Faculty of Medicine, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Scholefield+J%22">Scholefield J</searchLink>; Bioengineering and Integrated Genomics Group, Next Generation Health Cluster, Council for Scientific and Industrial Research, Pretoria, South Africa.; Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Batista+Silva+Júnior+J%22">Batista Silva Júnior J</searchLink>; Brazilian Health Regulatory Agency-ANVISA, Brasília, DF, Brazil.; Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Brasília, Brasília, DF, Brazil.<br /><searchLink fieldCode="AU" term="%22McCune+JM%22">McCune JM</searchLink>; HIV Frontiers, Global Health Accelerator, Bill & Melinda Gates Foundation, Seattle, WA, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2024 May 08; Vol. 16 (746), pp. eadn1902. <i>Date of Electronic Publication: </i>2024 May 08.
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