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Impact of LS Mutation on Pharmacokinetics of Preventive HIV Broadly Neutralizing Monoclonal Antibodies: A Cross-Protocol Analysis of 16 Clinical Trials in People without HIV.

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Title: Impact of LS Mutation on Pharmacokinetics of Preventive HIV Broadly Neutralizing Monoclonal Antibodies: A Cross-Protocol Analysis of 16 Clinical Trials in People without HIV.
Authors: Mayer BT; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Zhang L; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., deCamp AC; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Yu C; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Sato A; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Angier H; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Seaton KE; Duke University Medical Center, Durham, NC 27705, USA., Yates N; Duke University Medical Center, Durham, NC 27705, USA., Ledgerwood JE; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA., Mayer K; The Fenway Institute, Boston, MA 02215, USA., Caskey M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA., Nussenzweig M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA., Stephenson K; Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA 02139, USA., Julg B; Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA 02139, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Sobieszczyk ME; Columbia University Irving Medical Center, New York, NY 10032, USA., Edupuganti S; Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA., Kelley CF; Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA., McElrath MJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Gelderblom HC; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Pensiero M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA., McDermott A; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA., Gama L; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA., Koup RA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA., Gilbert PB; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA., Cohen MS; Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Corey L; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.; Departments of Medicine and Laboratory Medicine, University of Washington, Seattle, WA 98195, USA., Hyrien O; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Tomaras GD; Duke University Medical Center, Durham, NC 27705, USA., Huang Y; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.; Department of Global Health, University of Washington, Seattle, WA 98195, USA.
Source: Pharmaceutics [Pharmaceutics] 2024 Apr 27; Vol. 16 (5). Date of Electronic Publication: 2024 Apr 27.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Impact of LS Mutation on Pharmacokinetics of Preventive HIV Broadly Neutralizing Monoclonal Antibodies: A Cross-Protocol Analysis of 16 Clinical Trials in People without HIV.
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  Data: <searchLink fieldCode="AU" term="%22Mayer+BT%22">Mayer BT</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.<br /><searchLink fieldCode="AU" term="%22deCamp+AC%22">deCamp AC</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.<br /><searchLink fieldCode="AU" term="%22Yu+C%22">Yu C</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.<br /><searchLink fieldCode="AU" term="%22Sato+A%22">Sato A</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.<br /><searchLink fieldCode="AU" term="%22Angier+H%22">Angier H</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.<br /><searchLink fieldCode="AU" term="%22Seaton+KE%22">Seaton KE</searchLink>; Duke University Medical Center, Durham, NC 27705, USA.<br /><searchLink fieldCode="AU" term="%22Yates+N%22">Yates N</searchLink>; Duke University Medical Center, Durham, NC 27705, USA.<br /><searchLink fieldCode="AU" term="%22Ledgerwood+JE%22">Ledgerwood JE</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Mayer+K%22">Mayer K</searchLink>; The Fenway Institute, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Caskey+M%22">Caskey M</searchLink>; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Nussenzweig+M%22">Nussenzweig M</searchLink>; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Stephenson+K%22">Stephenson K</searchLink>; Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Julg+B%22">Julg B</searchLink>; Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA 02139, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Barouch+DH%22">Barouch DH</searchLink>; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Sobieszczyk+ME%22">Sobieszczyk ME</searchLink>; Columbia University Irving Medical Center, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Edupuganti+S%22">Edupuganti S</searchLink>; Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Kelley+CF%22">Kelley CF</searchLink>; Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22McElrath+MJ%22">McElrath MJ</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.<br /><searchLink fieldCode="AU" term="%22Gelderblom+HC%22">Gelderblom HC</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.<br /><searchLink fieldCode="AU" term="%22Pensiero+M%22">Pensiero M</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22McDermott+A%22">McDermott A</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Gama+L%22">Gama L</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Koup+RA%22">Koup RA</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Gilbert+PB%22">Gilbert PB</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Cohen+MS%22">Cohen MS</searchLink>; Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.<br /><searchLink fieldCode="AU" term="%22Corey+L%22">Corey L</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.; Departments of Medicine and Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Hyrien+O%22">Hyrien O</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.<br /><searchLink fieldCode="AU" term="%22Tomaras+GD%22">Tomaras GD</searchLink>; Duke University Medical Center, Durham, NC 27705, USA.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.; Department of Global Health, University of Washington, Seattle, WA 98195, USA.
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  Data: <searchLink fieldCode="JN" term="%22101534003%22">Pharmaceutics</searchLink> [Pharmaceutics] 2024 Apr 27; Vol. 16 (5). <i>Date of Electronic Publication: </i>2024 Apr 27.
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