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ASXL1/TET2 genotype-based risk stratification outperforms ASXL1 mutational impact and is independent of mutant variant allele fractions in chronic myelomonocytic leukemia.

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Title: ASXL1/TET2 genotype-based risk stratification outperforms ASXL1 mutational impact and is independent of mutant variant allele fractions in chronic myelomonocytic leukemia.
Authors: Csizmar CM; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN., Gurney M; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN., Kanagal-Shamanna R; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX., Chien K; Division of Cancer Medicine, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX., Hammond D; Division of Cancer Medicine, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX., Lasho TL; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN., Finke CM; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN., Dean C; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN., Natu A; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN., Mangaonkar AA; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN., Al-Kali A; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN., Gangat N; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN., Tefferi A; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN., Alkhateeb H; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN., Garcia-Manero G; Division of Cancer Medicine, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX., Komrokji RS; Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL., Ali NA; Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL., Padron E; Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL., Montalban-Bravo G; Division of Cancer Medicine, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX., Patnaik MM; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN. patnaik.mrinal@mayo.edu.
Source: Haematologica [Haematologica] 2024 Oct 01; Vol. 109 (10), pp. 3419-3425. Date of Electronic Publication: 2024 Oct 01.
Publication Type: Letter; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Ferrata Storti Foundation Country of Publication: Italy NLM ID: 0417435 Publication Model: Electronic Cited Medium: Internet ISSN: 1592-8721 (Electronic) Linking ISSN: 03906078 NLM ISO Abbreviation: Haematologica Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Report
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  Data: ASXL1/TET2 genotype-based risk stratification outperforms ASXL1 mutational impact and is independent of mutant variant allele fractions in chronic myelomonocytic leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Csizmar+CM%22">Csizmar CM</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Gurney+M%22">Gurney M</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Kanagal-Shamanna+R%22">Kanagal-Shamanna R</searchLink>; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Chien+K%22">Chien K</searchLink>; Division of Cancer Medicine, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Hammond+D%22">Hammond D</searchLink>; Division of Cancer Medicine, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Lasho+TL%22">Lasho TL</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Finke+CM%22">Finke CM</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Dean+C%22">Dean C</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Natu+A%22">Natu A</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Mangaonkar+AA%22">Mangaonkar AA</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Al-Kali+A%22">Al-Kali A</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Gangat+N%22">Gangat N</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Tefferi+A%22">Tefferi A</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Alkhateeb+H%22">Alkhateeb H</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Garcia-Manero+G%22">Garcia-Manero G</searchLink>; Division of Cancer Medicine, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Komrokji+RS%22">Komrokji RS</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Ali+NA%22">Ali NA</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Padron+E%22">Padron E</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Montalban-Bravo+G%22">Montalban-Bravo G</searchLink>; Division of Cancer Medicine, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Patnaik+MM%22">Patnaik MM</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN. patnaik.mrinal@mayo.edu.
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  Data: <searchLink fieldCode="JN" term="%220417435%22">Haematologica</searchLink> [Haematologica] 2024 Oct 01; Vol. 109 (10), pp. 3419-3425. <i>Date of Electronic Publication: </i>2024 Oct 01.
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  Data: Letter; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Ferrata+Storti+Foundation%22">Ferrata Storti Foundation </searchLink><i>Country of Publication: </i>Italy <i>NLM ID: </i>0417435 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1592-8721 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203906078%22">03906078 </searchLink><i>NLM ISO Abbreviation: </i>Haematologica <i>Subsets: </i>MEDLINE
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        Value: 10.3324/haematol.2024.285410
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        Text: English
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      – TitleFull: ASXL1/TET2 genotype-based risk stratification outperforms ASXL1 mutational impact and is independent of mutant variant allele fractions in chronic myelomonocytic leukemia.
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