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Complete substitution with modified nucleotides in self-amplifying RNA suppresses the interferon response and increases potency.

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Title: Complete substitution with modified nucleotides in self-amplifying RNA suppresses the interferon response and increases potency.
Authors: McGee JE; Department of Biomedical Engineering, Boston University, Boston, MA, USA.; Biological Design Center, Boston University, Boston, MA, USA., Kirsch JR; Department of Biomedical Engineering, Boston University, Boston, MA, USA., Kenney D; Department of Virology, Immunology and Microbiology, Boston University School of Medicine, Boston, MA, USA.; National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA, USA., Cerbo F; Department of Virology, Immunology and Microbiology, Boston University School of Medicine, Boston, MA, USA.; National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA, USA., Chavez EC; Department of Virology, Immunology and Microbiology, Boston University School of Medicine, Boston, MA, USA.; National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA, USA., Shih TY; Department of Chemistry, Boston University, Boston, MA, USA., Douam F; Department of Virology, Immunology and Microbiology, Boston University School of Medicine, Boston, MA, USA. fdouam@bu.edu.; National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA, USA. fdouam@bu.edu., Wong WW; Department of Biomedical Engineering, Boston University, Boston, MA, USA. wilwong@bu.edu.; Biological Design Center, Boston University, Boston, MA, USA. wilwong@bu.edu., Grinstaff MW; Department of Biomedical Engineering, Boston University, Boston, MA, USA. mgrin@bu.edu.; Department of Chemistry, Boston University, Boston, MA, USA. mgrin@bu.edu.
Source: Nature biotechnology [Nat Biotechnol] 2025 May; Vol. 43 (5), pp. 720-726. Date of Electronic Publication: 2024 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22McGee+JE%22">McGee JE</searchLink>; Department of Biomedical Engineering, Boston University, Boston, MA, USA.; Biological Design Center, Boston University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kirsch+JR%22">Kirsch JR</searchLink>; Department of Biomedical Engineering, Boston University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kenney+D%22">Kenney D</searchLink>; Department of Virology, Immunology and Microbiology, Boston University School of Medicine, Boston, MA, USA.; National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cerbo+F%22">Cerbo F</searchLink>; Department of Virology, Immunology and Microbiology, Boston University School of Medicine, Boston, MA, USA.; National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chavez+EC%22">Chavez EC</searchLink>; Department of Virology, Immunology and Microbiology, Boston University School of Medicine, Boston, MA, USA.; National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Shih+TY%22">Shih TY</searchLink>; Department of Chemistry, Boston University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Douam+F%22">Douam F</searchLink>; Department of Virology, Immunology and Microbiology, Boston University School of Medicine, Boston, MA, USA. fdouam@bu.edu.; National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA, USA. fdouam@bu.edu.<br /><searchLink fieldCode="AU" term="%22Wong+WW%22">Wong WW</searchLink>; Department of Biomedical Engineering, Boston University, Boston, MA, USA. wilwong@bu.edu.; Biological Design Center, Boston University, Boston, MA, USA. wilwong@bu.edu.<br /><searchLink fieldCode="AU" term="%22Grinstaff+MW%22">Grinstaff MW</searchLink>; Department of Biomedical Engineering, Boston University, Boston, MA, USA. mgrin@bu.edu.; Department of Chemistry, Boston University, Boston, MA, USA. mgrin@bu.edu.
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  Data: <searchLink fieldCode="JN" term="%229604648%22">Nature biotechnology</searchLink> [Nat Biotechnol] 2025 May; Vol. 43 (5), pp. 720-726. <i>Date of Electronic Publication: </i>2024 Jul 08.
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