Complete substitution with modified nucleotides in self-amplifying RNA suppresses the interferon response and increases potency.
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| Title: | Complete substitution with modified nucleotides in self-amplifying RNA suppresses the interferon response and increases potency. |
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| Authors: | McGee JE; Department of Biomedical Engineering, Boston University, Boston, MA, USA.; Biological Design Center, Boston University, Boston, MA, USA., Kirsch JR; Department of Biomedical Engineering, Boston University, Boston, MA, USA., Kenney D; Department of Virology, Immunology and Microbiology, Boston University School of Medicine, Boston, MA, USA.; National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA, USA., Cerbo F; Department of Virology, Immunology and Microbiology, Boston University School of Medicine, Boston, MA, USA.; National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA, USA., Chavez EC; Department of Virology, Immunology and Microbiology, Boston University School of Medicine, Boston, MA, USA.; National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA, USA., Shih TY; Department of Chemistry, Boston University, Boston, MA, USA., Douam F; Department of Virology, Immunology and Microbiology, Boston University School of Medicine, Boston, MA, USA. fdouam@bu.edu.; National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA, USA. fdouam@bu.edu., Wong WW; Department of Biomedical Engineering, Boston University, Boston, MA, USA. wilwong@bu.edu.; Biological Design Center, Boston University, Boston, MA, USA. wilwong@bu.edu., Grinstaff MW; Department of Biomedical Engineering, Boston University, Boston, MA, USA. mgrin@bu.edu.; Department of Chemistry, Boston University, Boston, MA, USA. mgrin@bu.edu. |
| Source: | Nature biotechnology [Nat Biotechnol] 2025 May; Vol. 43 (5), pp. 720-726. Date of Electronic Publication: 2024 Jul 08. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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