Skeletal muscle p53-depletion uncovers a mechanism of fuel usage suppression that enables efficient energy conservation.

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Title: Skeletal muscle p53-depletion uncovers a mechanism of fuel usage suppression that enables efficient energy conservation.
Authors: Lenihan-Geels G; Department of Adipocyte Development and Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany., Garcia Carrizo F; Department of Adipocyte Development and Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany., Leer M; Department of Adipocyte Development and Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany., Gohlke S; Department of Adipocyte Development and Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany., Oster M; Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pharmacology, Max Rubner Center (MRC) for Cardiovascular-Metabolic-Renal Research, Berlin, Germany., Pöhle-Kronawitter S; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany., Ott C; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany., Chadt A; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany., Reinisch IN; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria., Galhuber M; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria., Li C; Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pharmacology, Max Rubner Center (MRC) for Cardiovascular-Metabolic-Renal Research, Berlin, Germany., Jonas W; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany., Jähnert M; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany., Klaus S; Department Physiology of Energy Metabolism, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany., Al-Hasani H; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany., Grune T; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany., Schürmann A; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany., Madl T; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.; BioTechMed-Graz, Graz, Austria., Prokesch A; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria.; BioTechMed-Graz, Graz, Austria., Schupp M; Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pharmacology, Max Rubner Center (MRC) for Cardiovascular-Metabolic-Renal Research, Berlin, Germany., Schulz TJ; Department of Adipocyte Development and Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Institute of Nutritional Science, University of Potsdam, Potsdam-Rehbrücke, Nuthetal, Germany.
Source: Journal of cachexia, sarcopenia and muscle [J Cachexia Sarcopenia Muscle] 2024 Oct; Vol. 15 (5), pp. 1772-1784. Date of Electronic Publication: 2024 Jul 15.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders Country of Publication: Germany NLM ID: 101552883 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-6009 (Electronic) Linking ISSN: 21905991 NLM ISO Abbreviation: J Cachexia Sarcopenia Muscle Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Skeletal muscle p53-depletion uncovers a mechanism of fuel usage suppression that enables efficient energy conservation.
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  Data: <searchLink fieldCode="AU" term="%22Lenihan-Geels+G%22">Lenihan-Geels G</searchLink>; Department of Adipocyte Development and Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany.<br /><searchLink fieldCode="AU" term="%22Garcia+Carrizo+F%22">Garcia Carrizo F</searchLink>; Department of Adipocyte Development and Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Leer+M%22">Leer M</searchLink>; Department of Adipocyte Development and Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Gohlke+S%22">Gohlke S</searchLink>; Department of Adipocyte Development and Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany.<br /><searchLink fieldCode="AU" term="%22Oster+M%22">Oster M</searchLink>; Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pharmacology, Max Rubner Center (MRC) for Cardiovascular-Metabolic-Renal Research, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Pöhle-Kronawitter+S%22">Pöhle-Kronawitter S</searchLink>; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.<br /><searchLink fieldCode="AU" term="%22Ott+C%22">Ott C</searchLink>; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.<br /><searchLink fieldCode="AU" term="%22Chadt+A%22">Chadt A</searchLink>; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Reinisch+IN%22">Reinisch IN</searchLink>; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Galhuber+M%22">Galhuber M</searchLink>; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pharmacology, Max Rubner Center (MRC) for Cardiovascular-Metabolic-Renal Research, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Jonas+W%22">Jonas W</searchLink>; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.<br /><searchLink fieldCode="AU" term="%22Jähnert+M%22">Jähnert M</searchLink>; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.<br /><searchLink fieldCode="AU" term="%22Klaus+S%22">Klaus S</searchLink>; Department Physiology of Energy Metabolism, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.<br /><searchLink fieldCode="AU" term="%22Al-Hasani+H%22">Al-Hasani H</searchLink>; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Grune+T%22">Grune T</searchLink>; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.<br /><searchLink fieldCode="AU" term="%22Schürmann+A%22">Schürmann A</searchLink>; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.<br /><searchLink fieldCode="AU" term="%22Madl+T%22">Madl T</searchLink>; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.; BioTechMed-Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Prokesch+A%22">Prokesch A</searchLink>; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria.; BioTechMed-Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Schupp+M%22">Schupp M</searchLink>; Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pharmacology, Max Rubner Center (MRC) for Cardiovascular-Metabolic-Renal Research, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Schulz+TJ%22">Schulz TJ</searchLink>; Department of Adipocyte Development and Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Institute of Nutritional Science, University of Potsdam, Potsdam-Rehbrücke, Nuthetal, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101552883%22">Journal of cachexia, sarcopenia and muscle</searchLink> [J Cachexia Sarcopenia Muscle] 2024 Oct; Vol. 15 (5), pp. 1772-1784. <i>Date of Electronic Publication: </i>2024 Jul 15.
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