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Dihydroisotanshinone I regulates ferroptosis via PI3K/AKT pathway to enhance cisplatin sensitivity in lung adenocarcinoma.

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Title: Dihydroisotanshinone I regulates ferroptosis via PI3K/AKT pathway to enhance cisplatin sensitivity in lung adenocarcinoma.
Authors: Li FJ; The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Shaoshan South Road No. 161, Changsha 410000, Hunan, China.; School of Pharmacy, University of South China, Changsheng West Road No. 28, Hengyang 421000, Hunan, China.; Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, No. 161, Shaoshan South Road, Hengyang 421000, Hunan, China., Gao LC; The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Shaoshan South Road No. 161, Changsha 410000, Hunan, China.; School of Pharmacy, University of South China, Changsheng West Road No. 28, Hengyang 421000, Hunan, China.; Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, No. 161, Shaoshan South Road, Hengyang 421000, Hunan, China., Long HZ; The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Shaoshan South Road No. 161, Changsha 410000, Hunan, China.; School of Pharmacy, University of South China, Changsheng West Road No. 28, Hengyang 421000, Hunan, China.; Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, No. 161, Shaoshan South Road, Hengyang 421000, Hunan, China., Zhou ZW; The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Shaoshan South Road No. 161, Changsha 410000, Hunan, China.; School of Pharmacy, University of South China, Changsheng West Road No. 28, Hengyang 421000, Hunan, China.; Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, No. 161, Shaoshan South Road, Hengyang 421000, Hunan, China., Luo HY; The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Shaoshan South Road No. 161, Changsha 410000, Hunan, China.; School of Pharmacy, University of South China, Changsheng West Road No. 28, Hengyang 421000, Hunan, China.; Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, No. 161, Shaoshan South Road, Hengyang 421000, Hunan, China., Xu SG; The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Shaoshan South Road No. 161, Changsha 410000, Hunan, China.; School of Pharmacy, University of South China, Changsheng West Road No. 28, Hengyang 421000, Hunan, China.; Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, No. 161, Shaoshan South Road, Hengyang 421000, Hunan, China., Dai SM; The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Shaoshan South Road No. 161, Changsha 410000, Hunan, China.; School of Pharmacy, University of South China, Changsheng West Road No. 28, Hengyang 421000, Hunan, China.; Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, No. 161, Shaoshan South Road, Hengyang 421000, Hunan, China., Hu JD; The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Shaoshan South Road No. 161, Changsha 410000, Hunan, China.; School of Pharmacy, University of South China, Changsheng West Road No. 28, Hengyang 421000, Hunan, China.; Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, No. 161, Shaoshan South Road, Hengyang 421000, Hunan, China.
Source: The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 2025 Jun 09; Vol. 77 (6), pp. 752-767.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0376363 Publication Model: Print Cited Medium: Internet ISSN: 2042-7158 (Electronic) Linking ISSN: 00223573 NLM ISO Abbreviation: J Pharm Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Dihydroisotanshinone I regulates ferroptosis via PI3K/AKT pathway to enhance cisplatin sensitivity in lung adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Li+FJ%22">Li FJ</searchLink>; The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Shaoshan South Road No. 161, Changsha 410000, Hunan, China.; School of Pharmacy, University of South China, Changsheng West Road No. 28, Hengyang 421000, Hunan, China.; Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, No. 161, Shaoshan South Road, Hengyang 421000, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Gao+LC%22">Gao LC</searchLink>; The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Shaoshan South Road No. 161, Changsha 410000, Hunan, China.; School of Pharmacy, University of South China, Changsheng West Road No. 28, Hengyang 421000, Hunan, China.; Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, No. 161, Shaoshan South Road, Hengyang 421000, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Long+HZ%22">Long HZ</searchLink>; The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Shaoshan South Road No. 161, Changsha 410000, Hunan, China.; School of Pharmacy, University of South China, Changsheng West Road No. 28, Hengyang 421000, Hunan, China.; Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, No. 161, Shaoshan South Road, Hengyang 421000, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Zhou+ZW%22">Zhou ZW</searchLink>; The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Shaoshan South Road No. 161, Changsha 410000, Hunan, China.; School of Pharmacy, University of South China, Changsheng West Road No. 28, Hengyang 421000, Hunan, China.; Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, No. 161, Shaoshan South Road, Hengyang 421000, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Luo+HY%22">Luo HY</searchLink>; The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Shaoshan South Road No. 161, Changsha 410000, Hunan, China.; School of Pharmacy, University of South China, Changsheng West Road No. 28, Hengyang 421000, Hunan, China.; Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, No. 161, Shaoshan South Road, Hengyang 421000, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Xu+SG%22">Xu SG</searchLink>; The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Shaoshan South Road No. 161, Changsha 410000, Hunan, China.; School of Pharmacy, University of South China, Changsheng West Road No. 28, Hengyang 421000, Hunan, China.; Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, No. 161, Shaoshan South Road, Hengyang 421000, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Dai+SM%22">Dai SM</searchLink>; The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Shaoshan South Road No. 161, Changsha 410000, Hunan, China.; School of Pharmacy, University of South China, Changsheng West Road No. 28, Hengyang 421000, Hunan, China.; Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, No. 161, Shaoshan South Road, Hengyang 421000, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Hu+JD%22">Hu JD</searchLink>; The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Shaoshan South Road No. 161, Changsha 410000, Hunan, China.; School of Pharmacy, University of South China, Changsheng West Road No. 28, Hengyang 421000, Hunan, China.; Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, No. 161, Shaoshan South Road, Hengyang 421000, Hunan, China.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0376363 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2042-7158 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200223573%22">00223573 </searchLink><i>NLM ISO Abbreviation: </i>J Pharm Pharmacol <i>Subsets: </i>MEDLINE
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        Value: 10.1093/jpp/rgae085
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      – Code: eng
        Text: English
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        StartPage: 752
    Titles:
      – TitleFull: Dihydroisotanshinone I regulates ferroptosis via PI3K/AKT pathway to enhance cisplatin sensitivity in lung adenocarcinoma.
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            NameFull: Li FJ
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            – D: 09
              M: 06
              Text: 2025 Jun 09
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              Y: 2025
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