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γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS).

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Title: γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS).
Authors: Schultz SA; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Medical School, Harvard University, Boston, MA, USA., Liu L; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Ann Romney Center for Neurologic Diseases, Boston, MA, USA., Schultz AP; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Medical School, Harvard University, Boston, MA, USA., Fitzpatrick CD; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Medical School, Harvard University, Boston, MA, USA., Levin R; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Medical School, Harvard University, Boston, MA, USA., Bellier JP; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Ann Romney Center for Neurologic Diseases, Boston, MA, USA., Shirzadi Z; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Medical School, Harvard University, Boston, MA, USA; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Joseph-Mathurin N; Mallinckrodt Institute of Radiology, Washington University, St Louis, MO, USA., Chen CD; Mallinckrodt Institute of Radiology, Washington University, St Louis, MO, USA., Benzinger TLS; Mallinckrodt Institute of Radiology, Washington University, St Louis, MO, USA., Day GS; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Farlow MR; Indiana Alzheimer's Disease Research Center, Indianapolis, IN, USA., Gordon BA; Mallinckrodt Institute of Radiology, Washington University, St Louis, MO, USA., Hassenstab JJ; Department of Psychology, Washington University, St Louis, MO, USA., Jack CR Jr; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Jucker M; German Center for Neurodegenerative Diseases, Tübingen, Germany., Karch CM; Department of Psychiatry, Washington University, St Louis, MO, USA., Lee JH; Department of Neurology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, South Korea., Levin J; German Center for Neurodegenerative Diseases, Munich, Germany; Department of Neurology, Ludwig Maximilian University of Munich, Munich, Germany; Munich Cluster for Systems Neurology, Munich, Germany., Perrin RJ; Department of Psychiatry, Washington University, St Louis, MO, USA; Department of Pathology and Immunology, Washington University, St Louis, MO, USA., Schofield PR; Neuroscience Research Australia, Randwick, NSW, Australia; School of Biomedical Sciences, University of New South Wales, Sydney, NSW, Australia., Xiong C; Division of Biostatistics, Washington University, St Louis, MO, USA., Johnson KA; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Medical School, Harvard University, Boston, MA, USA., McDade E; Department of Neurology, Washington University, St Louis, MO, USA., Bateman RJ; Department of Neurology, Washington University, St Louis, MO, USA., Sperling RA; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Medical School, Harvard University, Boston, MA, USA; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Selkoe DJ; Department of Neurology, Medical School, Harvard University, Boston, MA, USA; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Ann Romney Center for Neurologic Diseases, Boston, MA, USA., Chhatwal JP; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Medical School, Harvard University, Boston, MA, USA; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Ann Romney Center for Neurologic Diseases, Boston, MA, USA. Electronic address: chhatwal.jasmeer@mgh.harvard.edu.
Corporate Authors: Dominantly Inherited Alzheimer Network
Source: The Lancet. Neurology [Lancet Neurol] 2024 Sep; Vol. 23 (9), pp. 913-924. Date of Electronic Publication: 2024 Jul 26.
Publication Type: Journal Article; Multicenter Study; Observational Study; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 101139309 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-4465 (Electronic) Linking ISSN: 14744422 NLM ISO Abbreviation: Lancet Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS).
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  Data: <searchLink fieldCode="AU" term="%22Schultz+SA%22">Schultz SA</searchLink>; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Medical School, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Ann Romney Center for Neurologic Diseases, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Schultz+AP%22">Schultz AP</searchLink>; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Medical School, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fitzpatrick+CD%22">Fitzpatrick CD</searchLink>; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Medical School, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Levin+R%22">Levin R</searchLink>; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; 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Division of Biostatistics, Washington University, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+KA%22">Johnson KA</searchLink>; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Medical School, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22McDade+E%22">McDade E</searchLink>; Department of Neurology, Washington University, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Bateman+RJ%22">Bateman RJ</searchLink>; Department of Neurology, Washington University, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Sperling+RA%22">Sperling RA</searchLink>; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Medical School, Harvard University, Boston, MA, USA; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Selkoe+DJ%22">Selkoe DJ</searchLink>; Department of Neurology, Medical School, Harvard University, Boston, MA, USA; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Ann Romney Center for Neurologic Diseases, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chhatwal+JP%22">Chhatwal JP</searchLink>; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Medical School, Harvard University, Boston, MA, USA; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Ann Romney Center for Neurologic Diseases, Boston, MA, USA. Electronic address: chhatwal.jasmeer@mgh.harvard.edu.
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  Data: <searchLink fieldCode="CA" term="%22Dominantly+Inherited+Alzheimer+Network%22">Dominantly Inherited Alzheimer Network</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22101139309%22">The Lancet. Neurology</searchLink> [Lancet Neurol] 2024 Sep; Vol. 23 (9), pp. 913-924. <i>Date of Electronic Publication: </i>2024 Jul 26.
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