The VLA-4 integrin is constitutively active in circulating chronic lymphocytic leukemia cells via BCR autonomous signaling: a novel anchor-independent mechanism exploiting soluble blood-borne ligands.
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| Title: | The VLA-4 integrin is constitutively active in circulating chronic lymphocytic leukemia cells via BCR autonomous signaling: a novel anchor-independent mechanism exploiting soluble blood-borne ligands. |
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| Authors: | Tissino E; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy. etissino@cro.it., Gaglio A; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Nicolò A; Institut für Immunologie, Universitätsklinikum Ulm, Ulm, Germany., Pozzo F; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Bittolo T; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Rossi FM; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Bomben R; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Nanni P; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Cattarossi I; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Zaina E; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Zimbo AM; Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, Italy.; Haematology Unit, Azienda Ospedaliera Annunziata, Cosenza, Italy., Ianna G; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Capasso G; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Forestieri G; Laboratory of Experimental Hematology, Institute of Oncology Research, Bellinzona, Switzerland., Moia R; Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy., Datta M; Institut für Immunologie, Universitätsklinikum Ulm, Ulm, Germany., Härzschel A; Department of Internal Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Olivieri J; Clinica Ematologica, Centro Trapianti e Terapie Cellulari 'Carlo Melzi' DISM, Azienda Ospedaliera Universitaria S. Maria Misericordia, Udine, Italy., D'Arena G; Hematology, 'S. Luca' Hospital, ASL Salerno, Vallo della Lucania, Italy., Laurenti L; Fondazione Policlinico Universitario A Gemelli, IRCCS, Rome, Italy., Zaja F; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy., Chiarenza A; Division of Hematology, Ferrarotto Hospital, University of Catania, Catania, Italy., Palumbo GA; Dipartimento di Scienze Mediche, Chirurgiche e Tecnologie Avanzate 'G.F. Ingrassia', University of Catania, Catania, Italy., Martino EA; Haematology Unit, Azienda Ospedaliera Annunziata, Cosenza, Italy., Gentile M; Haematology Unit, Azienda Ospedaliera Annunziata, Cosenza, Italy.; Department of Pharmacy, Health and Nutritional Science, University of Calabria, Rende, Italy., Rossi D; Laboratory of Experimental Hematology, Institute of Oncology Research, Bellinzona, Switzerland., Gaidano G; Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy., Del Poeta G; Division of Hematology, University of Tor Vergata, Rome, Italy., Laureana R; Division of Hematology, University of Tor Vergata, Rome, Italy., Del Principe MI; Division of Hematology, University of Tor Vergata, Rome, Italy., Maity PC; Institut für Experimentelle Tumorforschung, Universitätsklinikum Ulm, Ulm, Germany., Jumaa H; Institut für Immunologie, Universitätsklinikum Ulm, Ulm, Germany., Hartmann TN; Department of Internal Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Zucchetto A; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy. zucchetto.soecs@cro.it., Gattei V; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy. vgattei@cro.it. |
| Source: | Leukemia [Leukemia] 2024 Oct; Vol. 38 (10), pp. 2127-2140. Date of Electronic Publication: 2024 Aug 14. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 39143370 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The VLA-4 integrin is constitutively active in circulating chronic lymphocytic leukemia cells via BCR autonomous signaling: a novel anchor-independent mechanism exploiting soluble blood-borne ligands. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Tissino+E%22">Tissino E</searchLink>; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy. etissino@cro.it.<br /><searchLink fieldCode="AU" term="%22Gaglio+A%22">Gaglio A</searchLink>; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.<br /><searchLink fieldCode="AU" term="%22Nicolò+A%22">Nicolò A</searchLink>; Institut für Immunologie, Universitätsklinikum Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Pozzo+F%22">Pozzo F</searchLink>; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.<br /><searchLink fieldCode="AU" term="%22Bittolo+T%22">Bittolo T</searchLink>; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.<br /><searchLink fieldCode="AU" term="%22Rossi+FM%22">Rossi FM</searchLink>; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.<br /><searchLink fieldCode="AU" term="%22Bomben+R%22">Bomben R</searchLink>; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.<br /><searchLink fieldCode="AU" term="%22Nanni+P%22">Nanni P</searchLink>; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.<br /><searchLink fieldCode="AU" term="%22Cattarossi+I%22">Cattarossi I</searchLink>; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.<br /><searchLink fieldCode="AU" term="%22Zaina+E%22">Zaina E</searchLink>; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.<br /><searchLink fieldCode="AU" term="%22Zimbo+AM%22">Zimbo AM</searchLink>; Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, Italy.; Haematology Unit, Azienda Ospedaliera Annunziata, Cosenza, Italy.<br /><searchLink fieldCode="AU" term="%22Ianna+G%22">Ianna G</searchLink>; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.<br /><searchLink fieldCode="AU" term="%22Capasso+G%22">Capasso G</searchLink>; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.<br /><searchLink fieldCode="AU" term="%22Forestieri+G%22">Forestieri G</searchLink>; Laboratory of Experimental Hematology, Institute of Oncology Research, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Moia+R%22">Moia R</searchLink>; Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Datta+M%22">Datta M</searchLink>; Institut für Immunologie, Universitätsklinikum Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Härzschel+A%22">Härzschel A</searchLink>; Department of Internal Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Olivieri+J%22">Olivieri J</searchLink>; Clinica Ematologica, Centro Trapianti e Terapie Cellulari 'Carlo Melzi' DISM, Azienda Ospedaliera Universitaria S. Maria Misericordia, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22D'Arena+G%22">D'Arena G</searchLink>; Hematology, 'S. Luca' Hospital, ASL Salerno, Vallo della Lucania, Italy.<br /><searchLink fieldCode="AU" term="%22Laurenti+L%22">Laurenti L</searchLink>; Fondazione Policlinico Universitario A Gemelli, IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Zaja+F%22">Zaja F</searchLink>; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Chiarenza+A%22">Chiarenza A</searchLink>; Division of Hematology, Ferrarotto Hospital, University of Catania, Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Palumbo+GA%22">Palumbo GA</searchLink>; Dipartimento di Scienze Mediche, Chirurgiche e Tecnologie Avanzate 'G.F. Ingrassia', University of Catania, Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Martino+EA%22">Martino EA</searchLink>; Haematology Unit, Azienda Ospedaliera Annunziata, Cosenza, Italy.<br /><searchLink fieldCode="AU" term="%22Gentile+M%22">Gentile M</searchLink>; Haematology Unit, Azienda Ospedaliera Annunziata, Cosenza, Italy.; Department of Pharmacy, Health and Nutritional Science, University of Calabria, Rende, Italy.<br /><searchLink fieldCode="AU" term="%22Rossi+D%22">Rossi D</searchLink>; Laboratory of Experimental Hematology, Institute of Oncology Research, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gaidano+G%22">Gaidano G</searchLink>; Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Del+Poeta+G%22">Del Poeta G</searchLink>; Division of Hematology, University of Tor Vergata, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Laureana+R%22">Laureana R</searchLink>; Division of Hematology, University of Tor Vergata, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Del+Principe+MI%22">Del Principe MI</searchLink>; Division of Hematology, University of Tor Vergata, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Maity+PC%22">Maity PC</searchLink>; Institut für Experimentelle Tumorforschung, Universitätsklinikum Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Jumaa+H%22">Jumaa H</searchLink>; Institut für Immunologie, Universitätsklinikum Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Hartmann+TN%22">Hartmann TN</searchLink>; Department of Internal Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Zucchetto+A%22">Zucchetto A</searchLink>; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy. zucchetto.soecs@cro.it.<br /><searchLink fieldCode="AU" term="%22Gattei+V%22">Gattei V</searchLink>; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy. vgattei@cro.it. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%228704895%22">Leukemia</searchLink> [Leukemia] 2024 Oct; Vol. 38 (10), pp. 2127-2140. <i>Date of Electronic Publication: </i>2024 Aug 14. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%2C+Specialist+Journals%22">Nature Publishing Group, Specialist Journals </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8704895 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5551 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208876924%22">08876924 </searchLink><i>NLM ISO Abbreviation: </i>Leukemia <i>Subsets: </i>MEDLINE |
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