Safety and potential effects of intrathecal injection of allogeneic human umbilical cord mesenchymal stem cell-derived exosomes in complete subacute spinal cord injury: a first-in-human, single-arm, open-label, phase I clinical trial.
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| Title: | Safety and potential effects of intrathecal injection of allogeneic human umbilical cord mesenchymal stem cell-derived exosomes in complete subacute spinal cord injury: a first-in-human, single-arm, open-label, phase I clinical trial. |
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| Authors: | Akhlaghpasand M; Medical Biotechnology Research Center, AJA University of Medical Sciences, PO box: 1411718541, Tehran, Iran.; Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, PO box: 1988873554, Tehran, Iran., Tavanaei R; Medical Biotechnology Research Center, AJA University of Medical Sciences, PO box: 1411718541, Tehran, Iran., Hosseinpoor M; Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, PO box: 1988873554, Tehran, Iran.; Stem Cell Technology Research Center (STRC), Iran University of Medical Sciences (IUMS), Tehran, Iran., Yazdani KO; Department of cardiovascular diseases, Zahedan university of medical science, Zahedan, Iran., Soleimani A; Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, PO box: 1988873554, Tehran, Iran., Zoshk MY; Department of Pediatrics, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran., Soleimani M; Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran., Chamanara M; Department of Pharmacology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran., Ghorbani M; Medical Biotechnology Research Center, AJA University of Medical Sciences, PO box: 1411718541, Tehran, Iran.; Department of Medical Laboratory Sciences, School of Allied Medical Sciences, AJA University of Medical Sciences, Tehran, Iran., Deylami M; Department of ICU &Critical care, Faculty of Medicine, Loghman-e Hakim Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran., Zali A; Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, PO box: 1988873554, Tehran, Iran., Heidari R; Medical Biotechnology Research Center, AJA University of Medical Sciences, PO box: 1411718541, Tehran, Iran. r-heidary@ajaums.ac.ir.; Cancer Epidemiology Research Center, AJA University of Medical Sciences, Tehran, Iran. r-heidary@ajaums.ac.ir., Oraee-Yazdani S; Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, PO box: 1988873554, Tehran, Iran. saeed.o.yazdani@gmail.com. |
| Source: | Stem cell research & therapy [Stem Cell Res Ther] 2024 Aug 26; Vol. 15 (1), pp. 264. Date of Electronic Publication: 2024 Aug 26. |
| Publication Type: | Journal Article; Clinical Trial, Phase I; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1757-6512 |
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| DOI: | 10.1186/s13287-024-03868-0 |
