Safety and potential effects of intrathecal injection of allogeneic human umbilical cord mesenchymal stem cell-derived exosomes in complete subacute spinal cord injury: a first-in-human, single-arm, open-label, phase I clinical trial.
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| Title: | Safety and potential effects of intrathecal injection of allogeneic human umbilical cord mesenchymal stem cell-derived exosomes in complete subacute spinal cord injury: a first-in-human, single-arm, open-label, phase I clinical trial. |
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| Authors: | Akhlaghpasand M; Medical Biotechnology Research Center, AJA University of Medical Sciences, PO box: 1411718541, Tehran, Iran.; Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, PO box: 1988873554, Tehran, Iran., Tavanaei R; Medical Biotechnology Research Center, AJA University of Medical Sciences, PO box: 1411718541, Tehran, Iran., Hosseinpoor M; Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, PO box: 1988873554, Tehran, Iran.; Stem Cell Technology Research Center (STRC), Iran University of Medical Sciences (IUMS), Tehran, Iran., Yazdani KO; Department of cardiovascular diseases, Zahedan university of medical science, Zahedan, Iran., Soleimani A; Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, PO box: 1988873554, Tehran, Iran., Zoshk MY; Department of Pediatrics, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran., Soleimani M; Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran., Chamanara M; Department of Pharmacology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran., Ghorbani M; Medical Biotechnology Research Center, AJA University of Medical Sciences, PO box: 1411718541, Tehran, Iran.; Department of Medical Laboratory Sciences, School of Allied Medical Sciences, AJA University of Medical Sciences, Tehran, Iran., Deylami M; Department of ICU &Critical care, Faculty of Medicine, Loghman-e Hakim Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran., Zali A; Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, PO box: 1988873554, Tehran, Iran., Heidari R; Medical Biotechnology Research Center, AJA University of Medical Sciences, PO box: 1411718541, Tehran, Iran. r-heidary@ajaums.ac.ir.; Cancer Epidemiology Research Center, AJA University of Medical Sciences, Tehran, Iran. r-heidary@ajaums.ac.ir., Oraee-Yazdani S; Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, PO box: 1988873554, Tehran, Iran. saeed.o.yazdani@gmail.com. |
| Source: | Stem cell research & therapy [Stem Cell Res Ther] 2024 Aug 26; Vol. 15 (1), pp. 264. Date of Electronic Publication: 2024 Aug 26. |
| Publication Type: | Journal Article; Clinical Trial, Phase I; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 39183334 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Safety and potential effects of intrathecal injection of allogeneic human umbilical cord mesenchymal stem cell-derived exosomes in complete subacute spinal cord injury: a first-in-human, single-arm, open-label, phase I clinical trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Akhlaghpasand+M%22">Akhlaghpasand M</searchLink>; Medical Biotechnology Research Center, AJA University of Medical Sciences, PO box: 1411718541, Tehran, Iran.; Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, PO box: 1988873554, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Tavanaei+R%22">Tavanaei R</searchLink>; Medical Biotechnology Research Center, AJA University of Medical Sciences, PO box: 1411718541, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Hosseinpoor+M%22">Hosseinpoor M</searchLink>; Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, PO box: 1988873554, Tehran, Iran.; Stem Cell Technology Research Center (STRC), Iran University of Medical Sciences (IUMS), Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Yazdani+KO%22">Yazdani KO</searchLink>; Department of cardiovascular diseases, Zahedan university of medical science, Zahedan, Iran.<br /><searchLink fieldCode="AU" term="%22Soleimani+A%22">Soleimani A</searchLink>; Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, PO box: 1988873554, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Zoshk+MY%22">Zoshk MY</searchLink>; Department of Pediatrics, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Soleimani+M%22">Soleimani M</searchLink>; Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Chamanara+M%22">Chamanara M</searchLink>; Department of Pharmacology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Ghorbani+M%22">Ghorbani M</searchLink>; Medical Biotechnology Research Center, AJA University of Medical Sciences, PO box: 1411718541, Tehran, Iran.; Department of Medical Laboratory Sciences, School of Allied Medical Sciences, AJA University of Medical Sciences, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Deylami+M%22">Deylami M</searchLink>; Department of ICU &Critical care, Faculty of Medicine, Loghman-e Hakim Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Zali+A%22">Zali A</searchLink>; Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, PO box: 1988873554, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Heidari+R%22">Heidari R</searchLink>; Medical Biotechnology Research Center, AJA University of Medical Sciences, PO box: 1411718541, Tehran, Iran. r-heidary@ajaums.ac.ir.; Cancer Epidemiology Research Center, AJA University of Medical Sciences, Tehran, Iran. r-heidary@ajaums.ac.ir.<br /><searchLink fieldCode="AU" term="%22Oraee-Yazdani+S%22">Oraee-Yazdani S</searchLink>; Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, PO box: 1988873554, Tehran, Iran. saeed.o.yazdani@gmail.com. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101527581%22">Stem cell research & therapy</searchLink> [Stem Cell Res Ther] 2024 Aug 26; Vol. 15 (1), pp. 264. <i>Date of Electronic Publication: </i>2024 Aug 26. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial, Phase I; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101527581 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1757-6512 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217576512%22">17576512 </searchLink><i>NLM ISO Abbreviation: </i>Stem Cell Res Ther <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=39183334 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s13287-024-03868-0 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 264 Titles: – TitleFull: Safety and potential effects of intrathecal injection of allogeneic human umbilical cord mesenchymal stem cell-derived exosomes in complete subacute spinal cord injury: a first-in-human, single-arm, open-label, phase I clinical trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Akhlaghpasand M – PersonEntity: Name: NameFull: Tavanaei R – PersonEntity: Name: NameFull: Hosseinpoor M – PersonEntity: Name: NameFull: Yazdani KO – PersonEntity: Name: NameFull: Soleimani A – PersonEntity: Name: NameFull: Zoshk MY – PersonEntity: Name: NameFull: Soleimani M – PersonEntity: Name: NameFull: Chamanara M – PersonEntity: Name: NameFull: Ghorbani M – PersonEntity: Name: NameFull: Deylami M – PersonEntity: Name: NameFull: Zali A – PersonEntity: Name: NameFull: Heidari R – PersonEntity: Name: NameFull: Oraee-Yazdani S IsPartOfRelationships: – BibEntity: Dates: – D: 26 M: 08 Text: 2024 Aug 26 Type: published Y: 2024 Identifiers: – Type: issn-electronic Value: 1757-6512 Numbering: – Type: volume Value: 15 – Type: issue Value: 1 Titles: – TitleFull: Stem cell research & therapy Type: main |
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