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Vitamin D Alleviates Heavy Metal-Induced Cytotoxic Effects on Human Bone Osteoblasts Via the Induction of Bioenergetic Disruption, Oxidative Stress, and Apoptosis.

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Title: Vitamin D Alleviates Heavy Metal-Induced Cytotoxic Effects on Human Bone Osteoblasts Via the Induction of Bioenergetic Disruption, Oxidative Stress, and Apoptosis.
Authors: Elmorsy EM; Pathology Department, Faculty of Medicine, Northern Border University, 91431, Arar, Saudi Arabia. ekramy.elmorsy@nbu.edu.sa.; Center for Health Research, Northern Border University, Arar, Saudi Arabia. ekramy.elmorsy@nbu.edu.sa., Al-Ghafari AB; Department of Biochemistry, Faculty of Science, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.; Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University, 21589, Jeddah, Saudi Arabia., Al Doghaither HA; Department of Biochemistry, Faculty of Science, King Abdulaziz University, 21589, Jeddah, Saudi Arabia., Alrowaili MG; Department of Surgery (Orthopedic Division), Faculty of Medicine, Northern Border University, Arar, Saudi Arabia., Khired ZA; Department of Surgery, College of Medicine, Jazan University, 45142, Jazan, Saudi Arabia., Toraih EA; Department of Surgery, School of Medicine, Tulane University, New Orleans, LA, 70112, USA. etoraih@tulane.edu.; Genetics Unit, Department of Histology and Cell Biology, Suez Canal University, Ismailia, 41522, Egypt. etoraih@tulane.edu., Fawzy MS; Center for Health Research, Northern Border University, Arar, Saudi Arabia.; Department of Biochemistry, Faculty of Medicine, Northern Border University, 73213, Arar, Saudi Arabia.; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt., Shehata SA; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.
Source: Biological trace element research [Biol Trace Elem Res] 2025 Apr; Vol. 203 (4), pp. 2420-2434. Date of Electronic Publication: 2024 Sep 05.
Publication Type: Journal Article
Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 7911509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0720 (Electronic) Linking ISSN: 01634984 NLM ISO Abbreviation: Biol Trace Elem Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Vitamin D Alleviates Heavy Metal-Induced Cytotoxic Effects on Human Bone Osteoblasts Via the Induction of Bioenergetic Disruption, Oxidative Stress, and Apoptosis.
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  Data: <searchLink fieldCode="AU" term="%22Elmorsy+EM%22">Elmorsy EM</searchLink>; Pathology Department, Faculty of Medicine, Northern Border University, 91431, Arar, Saudi Arabia. ekramy.elmorsy@nbu.edu.sa.; Center for Health Research, Northern Border University, Arar, Saudi Arabia. ekramy.elmorsy@nbu.edu.sa.<br /><searchLink fieldCode="AU" term="%22Al-Ghafari+AB%22">Al-Ghafari AB</searchLink>; Department of Biochemistry, Faculty of Science, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.; Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Al+Doghaither+HA%22">Al Doghaither HA</searchLink>; Department of Biochemistry, Faculty of Science, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alrowaili+MG%22">Alrowaili MG</searchLink>; Department of Surgery (Orthopedic Division), Faculty of Medicine, Northern Border University, Arar, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Khired+ZA%22">Khired ZA</searchLink>; Department of Surgery, College of Medicine, Jazan University, 45142, Jazan, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Toraih+EA%22">Toraih EA</searchLink>; Department of Surgery, School of Medicine, Tulane University, New Orleans, LA, 70112, USA. etoraih@tulane.edu.; Genetics Unit, Department of Histology and Cell Biology, Suez Canal University, Ismailia, 41522, Egypt. etoraih@tulane.edu.<br /><searchLink fieldCode="AU" term="%22Fawzy+MS%22">Fawzy MS</searchLink>; Center for Health Research, Northern Border University, Arar, Saudi Arabia.; Department of Biochemistry, Faculty of Medicine, Northern Border University, 73213, Arar, Saudi Arabia.; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.<br /><searchLink fieldCode="AU" term="%22Shehata+SA%22">Shehata SA</searchLink>; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.
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  Data: <searchLink fieldCode="JN" term="%227911509%22">Biological trace element research</searchLink> [Biol Trace Elem Res] 2025 Apr; Vol. 203 (4), pp. 2420-2434. <i>Date of Electronic Publication: </i>2024 Sep 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Humana+Press%22">Humana Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7911509 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1559-0720 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201634984%22">01634984 </searchLink><i>NLM ISO Abbreviation: </i>Biol Trace Elem Res <i>Subsets: </i>MEDLINE
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              Text: 2025 Apr
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