Development and preclinical characterization of a novel radiotheranostic EphA2-targeting bicyclic peptide.

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Title: Development and preclinical characterization of a novel radiotheranostic EphA2-targeting bicyclic peptide.
Authors: El Fakiri M; Department of Nuclear Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany.; Division of Radiopharmaceutical Development, German Cancer Consortium (DKTK), partner site Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany and German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany., Regupathy AR; BicycleTx Limited, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom., Uhlmann L; Department of Nuclear Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany.; Division of Radiopharmaceutical Development, German Cancer Consortium (DKTK), partner site Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany and German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany., Ayada N; Department of Nuclear Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany.; Division of Radiopharmaceutical Development, German Cancer Consortium (DKTK), partner site Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany and German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany., Geis NM; Department of Nuclear Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany.; Division of Radiopharmaceutical Development, German Cancer Consortium (DKTK), partner site Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany and German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany., Domogalla LC; Department of Nuclear Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany.; Division of Radiopharmaceutical Development, German Cancer Consortium (DKTK), partner site Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany and German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany., Lahdenranta J; Bicycle Therapeutics, 35 Cambridgepark Drive, Cambridge, MA, 02140, United States., Blakeman B; BicycleTx Limited, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom., Wood F; BicycleTx Limited, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom., Meyer PT; Department of Nuclear Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany., Huxley P; BicycleTx Limited, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom., Eder M; Department of Nuclear Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany.; Division of Radiopharmaceutical Development, German Cancer Consortium (DKTK), partner site Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany and German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany., Mudd GE; BicycleTx Limited, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom., Eder AC; Department of Nuclear Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany.; Division of Radiopharmaceutical Development, German Cancer Consortium (DKTK), partner site Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany and German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Source: Theranostics [Theranostics] 2024 Aug 06; Vol. 14 (12), pp. 4701-4712. Date of Electronic Publication: 2024 Aug 06 (Print Publication: 2024).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101552395 Publication Model: eCollection Cited Medium: Internet ISSN: 1838-7640 (Electronic) Linking ISSN: 18387640 NLM ISO Abbreviation: Theranostics Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1838-7640
DOI:10.7150/thno.96641