Blocking tumor-intrinsic MNK1 kinase restricts metabolic adaptation and diminishes liver metastasis.
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| Title: | Blocking tumor-intrinsic MNK1 kinase restricts metabolic adaptation and diminishes liver metastasis. |
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| Authors: | Preston SEJ; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada.; Gerald Bronfman Department of Oncology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, Canada., Dahabieh MS; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA., Flores González RE; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada.; Gerald Bronfman Department of Oncology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, Canada., Gonçalves C; Gerald Bronfman Department of Oncology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, Canada., Richard VR; Segal Cancer Proteomics Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, Canada., Leibovitch M; MUHC Research Institute, McGill University Health Centre, Montréal, QC, Canada., Dakin E; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada.; Gerald Bronfman Department of Oncology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, Canada., Papadopoulos T; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada.; Gerald Bronfman Department of Oncology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, Canada., Lopez Naranjo C; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada.; Gerald Bronfman Department of Oncology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, Canada., McCallum PA; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada.; Gerald Bronfman Department of Oncology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, Canada., Huang F; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada.; Gerald Bronfman Department of Oncology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, Canada., Gagnon N; Gerald Bronfman Department of Oncology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, Canada., Perrino S; MUHC Research Institute, McGill University Health Centre, Montréal, QC, Canada., Zahedi RP; Segal Cancer Proteomics Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, Canada.; Manitoba Centre for Proteomics and Systems Biology, University of Manitoba, Winnipeg, MB, Canada.; Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.; CancerCare Manitoba, Winnipeg, MB, Canada., Borchers CH; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada.; Gerald Bronfman Department of Oncology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, Canada.; Segal Cancer Proteomics Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, Canada.; Department of Pathology, McGill University, Montréal, QC, Canada., Jones RG; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA., Brodt P; MUHC Research Institute, McGill University Health Centre, Montréal, QC, Canada.; Departments of Surgery, Oncology and Medicine, McGill University, Montréal, QC, Canada., Miller WH Jr; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada.; Gerald Bronfman Department of Oncology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, Canada., Del Rincón SV; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada.; Gerald Bronfman Department of Oncology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, Canada. |
| Source: | Science advances [Sci Adv] 2024 Sep 13; Vol. 10 (37), pp. eadi7673. Date of Electronic Publication: 2024 Sep 13. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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