Topical adjunctive treatment with flagellin augments pulmonary neutrophil responses and reduces bacterial dissemination in multidrug-resistant K. pneumoniae infection.

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Title: Topical adjunctive treatment with flagellin augments pulmonary neutrophil responses and reduces bacterial dissemination in multidrug-resistant K. pneumoniae infection.
Authors: van Linge CCA; Center for Experimental and Molecular Medicine, Amsterdam University Medical Center, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Infection & Immunity Institute, Amsterdam, Netherlands., Kullberg RFJ; Center for Experimental and Molecular Medicine, Amsterdam University Medical Center, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Infection & Immunity Institute, Amsterdam, Netherlands., Chouchane O; Center for Experimental and Molecular Medicine, Amsterdam University Medical Center, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Infection & Immunity Institute, Amsterdam, Netherlands., Roelofs JJTH; Amsterdam Infection & Immunity Institute, Amsterdam, Netherlands.; Department of Pathology, Amsterdam University Medical Center, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands., Goessens WHF; Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, Netherlands., van 't Veer C; Center for Experimental and Molecular Medicine, Amsterdam University Medical Center, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Infection & Immunity Institute, Amsterdam, Netherlands., Sirard JC; Center for Infection and Immunity of Lille, Institut Pasteur de Lille, U1019 - UMR9017, centre hospitalier universitaire (CHU) Lille, Centre national de la recherche scientifique (CNRS), L'institut national de la santé et de la recherche médicale (INSERM), University of Lille, Lille, France., de Vos AF; Center for Experimental and Molecular Medicine, Amsterdam University Medical Center, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Infection & Immunity Institute, Amsterdam, Netherlands., van der Poll T; Center for Experimental and Molecular Medicine, Amsterdam University Medical Center, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Infection & Immunity Institute, Amsterdam, Netherlands.; Division of Infectious Diseases, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands.
Source: Frontiers in immunology [Front Immunol] 2024 Sep 04; Vol. 15, pp. 1450486. Date of Electronic Publication: 2024 Sep 04 (Print Publication: 2024).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
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  Data: Topical adjunctive treatment with flagellin augments pulmonary neutrophil responses and reduces bacterial dissemination in multidrug-resistant K. pneumoniae infection.
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  Data: <searchLink fieldCode="AU" term="%22van+Linge+CCA%22">van Linge CCA</searchLink>; Center for Experimental and Molecular Medicine, Amsterdam University Medical Center, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Infection & Immunity Institute, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Kullberg+RFJ%22">Kullberg RFJ</searchLink>; Center for Experimental and Molecular Medicine, Amsterdam University Medical Center, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Infection & Immunity Institute, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Chouchane+O%22">Chouchane O</searchLink>; Center for Experimental and Molecular Medicine, Amsterdam University Medical Center, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Infection & Immunity Institute, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Roelofs+JJTH%22">Roelofs JJTH</searchLink>; Amsterdam Infection & Immunity Institute, Amsterdam, Netherlands.; Department of Pathology, Amsterdam University Medical Center, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Goessens+WHF%22">Goessens WHF</searchLink>; Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+'t+Veer+C%22">van 't Veer C</searchLink>; Center for Experimental and Molecular Medicine, Amsterdam University Medical Center, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Infection & Immunity Institute, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Sirard+JC%22">Sirard JC</searchLink>; Center for Infection and Immunity of Lille, Institut Pasteur de Lille, U1019 - UMR9017, centre hospitalier universitaire (CHU) Lille, Centre national de la recherche scientifique (CNRS), L'institut national de la santé et de la recherche médicale (INSERM), University of Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22de+Vos+AF%22">de Vos AF</searchLink>; Center for Experimental and Molecular Medicine, Amsterdam University Medical Center, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Infection & Immunity Institute, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Poll+T%22">van der Poll T</searchLink>; Center for Experimental and Molecular Medicine, Amsterdam University Medical Center, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Infection & Immunity Institute, Amsterdam, Netherlands.; Division of Infectious Diseases, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2024 Sep 04; Vol. 15, pp. 1450486. <i>Date of Electronic Publication: </i>2024 Sep 04 (<i>Print Publication: </i>2024).
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              Text: 2024 Sep 04
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