Pharmacokinetics of Ganaplacide and Lumefantrine in Adults, Adolescents, and Children with Plasmodium falciparum Malaria Treated with Ganaplacide Plus Lumefantrine Solid Dispersion Formulation: Analysis of Data from a Multinational Phase 2 Study.
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| Title: | Pharmacokinetics of Ganaplacide and Lumefantrine in Adults, Adolescents, and Children with Plasmodium falciparum Malaria Treated with Ganaplacide Plus Lumefantrine Solid Dispersion Formulation: Analysis of Data from a Multinational Phase 2 Study. |
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| Authors: | Sangana R; PK Sciences, Biomedical Research, Novartis, Cambridge, MA, USA., Ogutu B; Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya and CREATES, Strathmore University, Nairobi, Kenya., Yeka A; Infectious Diseases Research Collaboration, Kampala, Uganda., Kusemererwa S; Medical Research Council/Uganda Virus Resea, rch Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda., Tinto H; Institut de Recherche en Science de la Santé - Unité de Recherche Clinique de Nanoro (IRSS-URCN), Nanoro, Burkina Faso., Toure AO; Department of Parasitology-Mycology, Institut Pasteur de Côte d'Ivoire, Abidjan, Côte d'Ivoire., Kibuuka A; Infectious Diseases Research Collaboration (IDRC), Kampala, Uganda., Lingani M; Institut de Recherche en Science de la Santé - Unité de Recherche Clinique de Nanoro (IRSS-URCN), Nanoro, Burkina Faso., Lourenço C; Chókwè Health Research and Training Center/Centro de Investigação e Treino em Saúde de Chókwè (CITSC), National Institute of Health, Mozambique., Mombo-Ngoma G; Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.; Department of Implementation Research, Bernhard Nocht Institute for Tropical Medicine and Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Nduba V; Kenya Medical Research Institute-Centre for Respiratory Diseases Research (KEMRI-CRDR), Nairobi, Kenya., Landry N'Guessan T; Department of Parasitology-Mycology, Institut Pasteur de Côte d'Ivoire, Abidjan, Côte d'Ivoire., Nassa GJW; Institut de Recherche en Science de la Santé - Unité de Recherche Clinique de Nanoro (IRSS-URCN), Nanoro, Burkina Faso., Nyantaro M; Medical Research Council/Uganda Virus Resea, rch Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda., Tina LO; Centre for Clinical Research, Kenya Medical Research Institute/US Army Medical Research Directorate, Kisumu, Kenya., Anvikar A; ICMR-National Institute of Malaria Research, New Delhi, India., Sinha A; ICMR-National Institute of Malaria Research, New Delhi, India., Kaguthi G; Kenya Medical Research Institute-Centre for Respiratory Diseases Research (KEMRI-CRDR), Nairobi, Kenya., Fofana B; Malaria Research and Training Center, Bamako, Mali., Grobusch MP; Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.; Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.; Institute of Tropical Medicine, University of Tubingen, Tubingen, Germany., Gaaloul ME; Medicines for Malaria Venture, Geneva, Switzerland., Marrast AC; Medicines for Malaria Venture, Geneva, Switzerland., Pathan R; Novartis Healthcare Pvt. Ltd., Hyderabad, India., Chikoto H; Novartis Healthcare Pvt. Ltd., Hyderabad, India., Csermak K; Novartis Healthcare Pvt. Ltd., Hyderabad, India., Risterucci C; Novartis Healthcare Pvt. Ltd., Hyderabad, India., Su G; Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA., Winnips C; Novartis Pharma AG, Basel, Switzerland., Zhang J; PK Sciences, Biomedical Research, Novartis, East Hanover, NJ, USA., Zack J; PK Sciences, Biomedical Research, Novartis, East Hanover, NJ, USA. |
| Source: | Journal of clinical pharmacology [J Clin Pharmacol] 2025 Feb; Vol. 65 (2), pp. 179-189. Date of Electronic Publication: 2024 Sep 29. |
| Publication Type: | Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial; Multicenter Study; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Wiley Country of Publication: England NLM ID: 0366372 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4604 (Electronic) Linking ISSN: 00912700 NLM ISO Abbreviation: J Clin Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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