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Tofacitinib prevents depressive-like behaviors through decreased hippocampal microgliosis and increased BDNF levels in both LPS-induced and CSDS-induced mice.

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Title: Tofacitinib prevents depressive-like behaviors through decreased hippocampal microgliosis and increased BDNF levels in both LPS-induced and CSDS-induced mice.
Authors: Gao YN; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, 210009, China.; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Pan KJ; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, 210009, China.; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Zhang YM; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Qi YB; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Chen WG; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, 210009, China.; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Zhou T; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Zong HC; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Guo HR; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Zhao JW; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Liu XC; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Cao ZT; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, 210009, China.; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Chen Z; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, 210009, China.; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Yin T; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Zang Y; Lingang Laboratory, Shanghai, 200120, China. yzang@lglab.ac.cn., Li J; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, 210009, China. jli@simm.ac.cn.; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. jli@simm.ac.cn.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China. jli@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. jli@simm.ac.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2025 Feb; Vol. 46 (2), pp. 353-365. Date of Electronic Publication: 2024 Sep 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Tofacitinib prevents depressive-like behaviors through decreased hippocampal microgliosis and increased BDNF levels in both LPS-induced and CSDS-induced mice.
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  Data: <searchLink fieldCode="AU" term="%22Gao+YN%22">Gao YN</searchLink>; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, 210009, China.; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Pan+KJ%22">Pan KJ</searchLink>; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, 210009, China.; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Zhang+YM%22">Zhang YM</searchLink>; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Qi+YB%22">Qi YB</searchLink>; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Chen+WG%22">Chen WG</searchLink>; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, 210009, China.; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Zhou+T%22">Zhou T</searchLink>; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Zong+HC%22">Zong HC</searchLink>; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Guo+HR%22">Guo HR</searchLink>; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Zhao+JW%22">Zhao JW</searchLink>; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Liu+XC%22">Liu XC</searchLink>; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Cao+ZT%22">Cao ZT</searchLink>; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, 210009, China.; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, 210009, China.; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Yin+T%22">Yin T</searchLink>; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Zang+Y%22">Zang Y</searchLink>; Lingang Laboratory, Shanghai, 200120, China. yzang@lglab.ac.cn.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, 210009, China. jli@simm.ac.cn.; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. jli@simm.ac.cn.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China. jli@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. jli@simm.ac.cn.
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  Data: <searchLink fieldCode="JN" term="%22100956087%22">Acta pharmacologica Sinica</searchLink> [Acta Pharmacol Sin] 2025 Feb; Vol. 46 (2), pp. 353-365. <i>Date of Electronic Publication: </i>2024 Sep 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100956087 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-7254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216714083%22">16714083 </searchLink><i>NLM ISO Abbreviation: </i>Acta Pharmacol Sin <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41401-024-01384-8
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        Text: English
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              Text: 2025 Feb
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