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Whole-genome sequencing in 333,100 individuals reveals rare non-coding single variant and aggregate associations with height.

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Title: Whole-genome sequencing in 333,100 individuals reveals rare non-coding single variant and aggregate associations with height.
Authors: Hawkes G; Clinical and Biomedical Sciences, University of Exeter, Exeter, UK. g.hawkes2@exeter.ac.uk., Beaumont RN; Clinical and Biomedical Sciences, University of Exeter, Exeter, UK., Li Z; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Mandla R; Department of Medicine, Harvard Medical School, Broad Institute, Boston, Massachusetts, USA., Li X; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Albert CM; Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Arnett DK; Provost Office, University of South Carolina, Columbia, SC, USA., Ashley-Koch AE; Department of Medicine, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA., Ashrani AA; Division of Hematology, Department of Medicine, Mayo Clinic Rochester, Rochester, MN, USA., Barnes KC; Department of Medicine, School of Medicine, University of Colorado, Aurora, CO, USA., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Carson AP; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Chami N; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Chung MK; Department of Cardiovascular Medicine, Heart, Vascular & Thoracic Institute, Cleveland, OH, USA., Curran JE; Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, TX, USA., Darbar D; Division of Cardiology, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA., Ellinor PT; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Fornage M; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Gordeuk VR; Department of Medicine, School of Medicine, University of Illinois at Chicago, Chicago, IL, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., He J; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA., Hwu CM; Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei City, Taiwan., Kalyani RR; GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Kaplan R; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Lubitz SA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Minster RL; Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA., Naseri T; Naseri & Associates Public Health Consultancy Firm and Family Health Clinic, Apia, Samoa.; International Health Institute, Brown University, Providence, Rhode Island, US., Viali S; Oceania University of Medicine, Apia, Samoa.; School of Medicine, National University of Samoa, Apia, Samoa.; Dept of Chronic Disease Epidemiology, Yale University, New Haven, Connecticut, US., Mitchell BD; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Murabito JM; Boston University's and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA., Palmer ND; Department of Biochemistry, Wake Forest University School of Medicine, Winston-, Salem, NC, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Departments of Medicine, Epidemiology, and Health Systems and Population Health, University of Washington, Seattle, WA, USA., Redline S; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA., Shoemaker MB; Department of Medicine, Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Silverman EK; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Telen MJ; Department of Medicine, Duke University School of Medicine, Durham, NC, USA., Weiss ST; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Yanek LR; GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Zhou H; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Liu CT; Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA., North KE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Justice AE; Population Health Sciences, Geisinger, Danville, PA, USA., Locke JM; Clinical and Biomedical Sciences, University of Exeter, Exeter, UK., Owens N; Clinical and Biomedical Sciences, University of Exeter, Exeter, UK., Murray A; Clinical and Biomedical Sciences, University of Exeter, Exeter, UK., Patel K; Clinical and Biomedical Sciences, University of Exeter, Exeter, UK., Frayling TM; Clinical and Biomedical Sciences, University of Exeter, Exeter, UK., Wright CF; Clinical and Biomedical Sciences, University of Exeter, Exeter, UK., Wood AR; Clinical and Biomedical Sciences, University of Exeter, Exeter, UK., Lin X; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Statistics, Harvard University, Cambridge, MA, USA., Manning A; Department of Medicine, Harvard Medical School, Broad Institute, Boston, Massachusetts, USA., Weedon MN; Clinical and Biomedical Sciences, University of Exeter, Exeter, UK. m.n.weedon@exeter.ac.uk.
Corporate Authors: NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
Source: Nature communications [Nat Commun] 2024 Oct 03; Vol. 15 (1), pp. 8549. Date of Electronic Publication: 2024 Oct 03.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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            NameFull: Frayling TM
      – PersonEntity:
          Name:
            NameFull: Wright CF
      – PersonEntity:
          Name:
            NameFull: Wood AR
      – PersonEntity:
          Name:
            NameFull: Lin X
      – PersonEntity:
          Name:
            NameFull: Manning A
      – PersonEntity:
          Name:
            NameFull: Weedon MN
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 03
              M: 10
              Text: 2024 Oct 03
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 15
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1