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A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features.

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Title: A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features.
Authors: Klughammer J; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA. klughammer@genzentrum.lmu.de.; Gene Center and Department of Biochemistry, Ludwig Maximilians Universität München, Munich, Germany. klughammer@genzentrum.lmu.de., Abravanel DL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. daniel_abravanel@dfci.harvard.edu.; Harvard Medical School, Boston, MA, USA. daniel_abravanel@dfci.harvard.edu., Segerstolpe Å; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Blosser TR; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Goltsev Y; Baxter Laboratory in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA., Cui Y; Department of Media Arts and Sciences, McGovern Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Goodwin DR; Department of Media Arts and Sciences, McGovern Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Sinha A; Department of Media Arts and Sciences, McGovern Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Ashenberg O; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Slyper M; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Vigneau S; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Jané-Valbuena J; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Alon S; Department of Media Arts and Sciences, McGovern Institute, Massachusetts Institute of Technology, Cambridge, MA, USA.; Faculty of Engineering, Gonda Brain Research Center and Institute of Nanotechnology, Bar-Ilan University, Ramat Gan, Israel., Caraccio C; Baxter Laboratory in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA., Chen J; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Cohen O; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Guiron University, Beersheba, Israel., Cullen N; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., DelloStritto LK; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Dionne D; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Files J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Frangieh A; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Helvie K; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Hughes ME; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Inga S; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Kanodia A; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Lako A; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., MacKichan C; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Mages S; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Gene Center and Department of Biochemistry, Ludwig Maximilians Universität München, Munich, Germany., Moriel N; School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel., Murray E; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Napolitano S; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Nguyen K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Nitzan M; School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel.; Racah Institute of Physics, The Hebrew University of Jerusalem, Jerusalem, Israel.; Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Ortiz R; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Patel M; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Pfaff KL; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Porter CBM; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Rotem A; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA.; AstraZeneca R&D, Boston, MA, USA., Strauss S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Strasser R; Gene Center and Department of Biochemistry, Ludwig Maximilians Universität München, Munich, Germany., Thorner AR; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Turner M; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, USA., Wakiro I; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Waldman J; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Wu J; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Gómez Tejeda Zañudo J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Zhang D; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Lin NU; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Tolaney SM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Winer EP; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Boyden ES; Department of Media Arts and Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.; K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA, USA., Chen F; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Nolan GP; Baxter Laboratory in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA., Rodig SJ; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA., Zhuang X; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Department of Physics, Harvard University, Cambridge, MA, USA., Rozenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Genentech, Inc., South San Francisco, CA, USA., Johnson BE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Regev A; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA. regev.aviv@gene.com.; Genentech, Inc., South San Francisco, CA, USA. regev.aviv@gene.com., Wagle N; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. wagle.nikhil@gene.com.; Harvard Medical School, Boston, MA, USA. wagle.nikhil@gene.com.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA. wagle.nikhil@gene.com.; Broad Institute of Harvard and MIT, Cambridge, MA, USA. wagle.nikhil@gene.com.; Genentech, Inc., South San Francisco, CA, USA. wagle.nikhil@gene.com.
Source: Nature medicine [Nat Med] 2024 Nov; Vol. 30 (11), pp. 3236-3249. Date of Electronic Publication: 2024 Oct 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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          Name:
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          Name:
            NameFull: Strauss S
      – PersonEntity:
          Name:
            NameFull: Strasser R
      – PersonEntity:
          Name:
            NameFull: Thorner AR
      – PersonEntity:
          Name:
            NameFull: Turner M
      – PersonEntity:
          Name:
            NameFull: Wakiro I
      – PersonEntity:
          Name:
            NameFull: Waldman J
      – PersonEntity:
          Name:
            NameFull: Wu J
      – PersonEntity:
          Name:
            NameFull: Gómez Tejeda Zañudo J
      – PersonEntity:
          Name:
            NameFull: Zhang D
      – PersonEntity:
          Name:
            NameFull: Lin NU
      – PersonEntity:
          Name:
            NameFull: Tolaney SM
      – PersonEntity:
          Name:
            NameFull: Winer EP
      – PersonEntity:
          Name:
            NameFull: Boyden ES
      – PersonEntity:
          Name:
            NameFull: Chen F
      – PersonEntity:
          Name:
            NameFull: Nolan GP
      – PersonEntity:
          Name:
            NameFull: Rodig SJ
      – PersonEntity:
          Name:
            NameFull: Zhuang X
      – PersonEntity:
          Name:
            NameFull: Rozenblatt-Rosen O
      – PersonEntity:
          Name:
            NameFull: Johnson BE
      – PersonEntity:
          Name:
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          Dates:
            – D: 01
              M: 11
              Text: 2024 Nov
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-electronic
              Value: 1546-170X
          Numbering:
            – Type: volume
              Value: 30
            – Type: issue
              Value: 11
          Titles:
            – TitleFull: Nature medicine
              Type: main
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