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A resurrected ancestor of Cas12a expands target access and substrate recognition for nucleic acid editing and detection.

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Title: A resurrected ancestor of Cas12a expands target access and substrate recognition for nucleic acid editing and detection.
Authors: Jabalera Y; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain., Tascón I; Ikerbasque Foundation for Science, Bilbao, Spain.; Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, Leioa, Spain., Samperio S; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain., López-Alonso JP; Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, Leioa, Spain.; Basque Resource for Electron Microscopy, Leioa, Spain., Gonzalez-Lopez M; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain., Aransay AM; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.; CIBERehd, ISCIII, Madrid, Spain., Abascal-Palacios G; Ikerbasque Foundation for Science, Bilbao, Spain.; Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, Leioa, Spain., Beisel CL; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany.; Medical Faculty, University of Würzburg, Würzburg, Germany., Ubarretxena-Belandia I; Ikerbasque Foundation for Science, Bilbao, Spain. ivan.ubarrechena@ehu.eus.; Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, Leioa, Spain. ivan.ubarrechena@ehu.eus., Perez-Jimenez R; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain. raulpjc@cicbiogune.es.; Ikerbasque Foundation for Science, Bilbao, Spain. raulpjc@cicbiogune.es.
Source: Nature biotechnology [Nat Biotechnol] 2025 Oct; Vol. 43 (10), pp. 1663-1672. Date of Electronic Publication: 2024 Oct 31.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A resurrected ancestor of Cas12a expands target access and substrate recognition for nucleic acid editing and detection.
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  Data: <searchLink fieldCode="AU" term="%22Jabalera+Y%22">Jabalera Y</searchLink>; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Tascón+I%22">Tascón I</searchLink>; Ikerbasque Foundation for Science, Bilbao, Spain.; Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, Leioa, Spain.<br /><searchLink fieldCode="AU" term="%22Samperio+S%22">Samperio S</searchLink>; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22López-Alonso+JP%22">López-Alonso JP</searchLink>; Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, Leioa, Spain.; Basque Resource for Electron Microscopy, Leioa, Spain.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Lopez+M%22">Gonzalez-Lopez M</searchLink>; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Aransay+AM%22">Aransay AM</searchLink>; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.; CIBERehd, ISCIII, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Abascal-Palacios+G%22">Abascal-Palacios G</searchLink>; Ikerbasque Foundation for Science, Bilbao, Spain.; Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, Leioa, Spain.<br /><searchLink fieldCode="AU" term="%22Beisel+CL%22">Beisel CL</searchLink>; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany.; Medical Faculty, University of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Ubarretxena-Belandia+I%22">Ubarretxena-Belandia I</searchLink>; Ikerbasque Foundation for Science, Bilbao, Spain. ivan.ubarrechena@ehu.eus.; Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, Leioa, Spain. ivan.ubarrechena@ehu.eus.<br /><searchLink fieldCode="AU" term="%22Perez-Jimenez+R%22">Perez-Jimenez R</searchLink>; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain. raulpjc@cicbiogune.es.; Ikerbasque Foundation for Science, Bilbao, Spain. raulpjc@cicbiogune.es.
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  Data: <searchLink fieldCode="JN" term="%229604648%22">Nature biotechnology</searchLink> [Nat Biotechnol] 2025 Oct; Vol. 43 (10), pp. 1663-1672. <i>Date of Electronic Publication: </i>2024 Oct 31.
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              Text: 2025 Oct
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