A resurrected ancestor of Cas12a expands target access and substrate recognition for nucleic acid editing and detection.
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| Title: | A resurrected ancestor of Cas12a expands target access and substrate recognition for nucleic acid editing and detection. |
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| Authors: | Jabalera Y; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain., Tascón I; Ikerbasque Foundation for Science, Bilbao, Spain.; Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, Leioa, Spain., Samperio S; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain., López-Alonso JP; Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, Leioa, Spain.; Basque Resource for Electron Microscopy, Leioa, Spain., Gonzalez-Lopez M; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain., Aransay AM; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.; CIBERehd, ISCIII, Madrid, Spain., Abascal-Palacios G; Ikerbasque Foundation for Science, Bilbao, Spain.; Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, Leioa, Spain., Beisel CL; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany.; Medical Faculty, University of Würzburg, Würzburg, Germany., Ubarretxena-Belandia I; Ikerbasque Foundation for Science, Bilbao, Spain. ivan.ubarrechena@ehu.eus.; Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, Leioa, Spain. ivan.ubarrechena@ehu.eus., Perez-Jimenez R; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain. raulpjc@cicbiogune.es.; Ikerbasque Foundation for Science, Bilbao, Spain. raulpjc@cicbiogune.es. |
| Source: | Nature biotechnology [Nat Biotechnol] 2025 Oct; Vol. 43 (10), pp. 1663-1672. Date of Electronic Publication: 2024 Oct 31. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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