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Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypes in the COPDGene and ECLIPSE cohort studies.

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Title: Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypes in the COPDGene and ECLIPSE cohort studies.
Authors: Moll M; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Division of Pulmonary, Critical Care, Sleep and Allergy, Veterans Affairs Boston Healthcare System, West Roxbury, MA, 02123, USA; Harvard Medical School, Boston, MA, 02115, USA., Hecker J; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA., Platig J; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, 22903, USA., Zhang J; The Pulmonary Center, Boston University Medical Center, Boston, MA 02118, USA., Ghosh AJ; Division of Pulmonary, Critical Care, and Sleep Medicine, SUNY Upstate Medical University, Syracuse, NY, 13210, USA., Pratte KA; Department of Biostatistics, National Jewish Health, Denver, CO, 80206, USA., Wang RS; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA., Hill D; Department of Electrical and Computer Engineering, Northeastern University, Boston, MA, 02115, USA., Konigsberg IR; Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA., Chiles JW 3rd; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35233, USA., Hersh CP; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA., Castaldi PJ; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35233, USA; Division of General Internal Medicine and Primary Care, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA., Glass K; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA., Dy JG; Department of Electrical and Computer Engineering, Northeastern University, Boston, MA, 02115, USA., Sin DD; Centre for Heart Lung Innovation, St. Paul's Hospital, and Department of Medicine (Respiratory Division), University of British Columbia, Vancouver, BC, Canada., Tal-Singer R; Global Allergy and Airways Patient Platform, Vienna, Austria., Mouded M; Novartis Institute for Biomedical Research, Cambridge, MA, USA., Rennard SI; Division of Pulmonary, Critical Care, and Sleep Medicine, University of Nebraska, Omaha, NE, 68198, USA., Anderson GP; Lung Health Research Centre, Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, Victoria, Australia., Kinney GL; Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA., Bowler RP; Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO, 80206, USA., Curtis JL; Division of Pulmonary and Critical Care Medicine, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USA; Medical Service, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI, 48109, USA., McDonald ML; Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA; Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 701, 19th Street S., LHRB 440, Birmingham, AL, 35233, USA; Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, 35233, USA., Silverman EK; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA., Hobbs BD; Regeneron Pharmaceutical, Tarrytown, NY, USA., Cho MH; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA. Electronic address: remhc@channing.harvard.edu.
Source: EBioMedicine [EBioMedicine] 2024 Dec; Vol. 110, pp. 105429. Date of Electronic Publication: 2024 Nov 06.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
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  Data: Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypes in the COPDGene and ECLIPSE cohort studies.
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  Data: <searchLink fieldCode="AU" term="%22Moll+M%22">Moll M</searchLink>; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Division of Pulmonary, Critical Care, Sleep and Allergy, Veterans Affairs Boston Healthcare System, West Roxbury, MA, 02123, USA; Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Hecker+J%22">Hecker J</searchLink>; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Platig+J%22">Platig J</searchLink>; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, 22903, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; The Pulmonary Center, Boston University Medical Center, Boston, MA 02118, USA.<br /><searchLink fieldCode="AU" term="%22Ghosh+AJ%22">Ghosh AJ</searchLink>; Division of Pulmonary, Critical Care, and Sleep Medicine, SUNY Upstate Medical University, Syracuse, NY, 13210, USA.<br /><searchLink fieldCode="AU" term="%22Pratte+KA%22">Pratte KA</searchLink>; Department of Biostatistics, National Jewish Health, Denver, CO, 80206, USA.<br /><searchLink fieldCode="AU" term="%22Wang+RS%22">Wang RS</searchLink>; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Hill+D%22">Hill D</searchLink>; Department of Electrical and Computer Engineering, Northeastern University, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Konigsberg+IR%22">Konigsberg IR</searchLink>; Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.<br /><searchLink fieldCode="AU" term="%22Chiles+JW+3rd%22">Chiles JW 3rd</searchLink>; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35233, USA.<br /><searchLink fieldCode="AU" term="%22Hersh+CP%22">Hersh CP</searchLink>; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Castaldi+PJ%22">Castaldi PJ</searchLink>; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35233, USA; Division of General Internal Medicine and Primary Care, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Glass+K%22">Glass K</searchLink>; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Dy+JG%22">Dy JG</searchLink>; Department of Electrical and Computer Engineering, Northeastern University, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Sin+DD%22">Sin DD</searchLink>; Centre for Heart Lung Innovation, St. Paul's Hospital, and Department of Medicine (Respiratory Division), University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Tal-Singer+R%22">Tal-Singer R</searchLink>; Global Allergy and Airways Patient Platform, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Mouded+M%22">Mouded M</searchLink>; Novartis Institute for Biomedical Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rennard+SI%22">Rennard SI</searchLink>; Division of Pulmonary, Critical Care, and Sleep Medicine, University of Nebraska, Omaha, NE, 68198, USA.<br /><searchLink fieldCode="AU" term="%22Anderson+GP%22">Anderson GP</searchLink>; Lung Health Research Centre, Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Kinney+GL%22">Kinney GL</searchLink>; Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.<br /><searchLink fieldCode="AU" term="%22Bowler+RP%22">Bowler RP</searchLink>; Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO, 80206, USA.<br /><searchLink fieldCode="AU" term="%22Curtis+JL%22">Curtis JL</searchLink>; Division of Pulmonary and Critical Care Medicine, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USA; Medical Service, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22McDonald+ML%22">McDonald ML</searchLink>; Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA; Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 701, 19th Street S., LHRB 440, Birmingham, AL, 35233, USA; Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, 35233, USA.<br /><searchLink fieldCode="AU" term="%22Silverman+EK%22">Silverman EK</searchLink>; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Hobbs+BD%22">Hobbs BD</searchLink>; Regeneron Pharmaceutical, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Cho+MH%22">Cho MH</searchLink>; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA. Electronic address: remhc@channing.harvard.edu.
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