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ReNeu: A Pivotal, Phase IIb Trial of Mirdametinib in Adults and Children With Symptomatic Neurofibromatosis Type 1-Associated Plexiform Neurofibroma.

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Title: ReNeu: A Pivotal, Phase IIb Trial of Mirdametinib in Adults and Children With Symptomatic Neurofibromatosis Type 1-Associated Plexiform Neurofibroma.
Authors: Moertel CL; Department of Pediatrics, University of Minnesota, Minneapolis, MN., Hirbe AC; Washington University School of Medicine in St Louis, St Louis, MO., Shuhaiber HH; University of Florida Clinical Research Center, Gainesville, FL., Bielamowicz K; The University of Arkansas for Medical Sciences/Arkansas Children's Hospital, Little Rock, AR., Sidhu A; University of Iowa Hospitals and Clinics, Iowa City, IA., Viskochil D; University of Utah, Salt Lake City, UT., Weber MD; SpringWorks Therapeutics, Inc, Stamford, CT., Lokku A; SpringWorks Therapeutics, Inc, Stamford, CT., Smith LM; SpringWorks Therapeutics, Inc, Stamford, CT., Foreman NK; Children's Hospital Colorado, Aurora, CO., Hajjar FM; AdventHealth for Children, Orlando, FL., McNall-Knapp RY; University of Oklahoma Health Sciences Center, Oklahoma City, OK., Weintraub L; Albany Medical Center, Albany, NY., Antony R; University of California Davis, Sacramento, CA., Franson AT; University of Michigan, Ann Arbor, MI., Meade J; University of Pittsburgh School of Medicine, Pittsburgh, PA., Schiff D; University of Virginia Medical Center, Charlottesville, VA., Walbert T; Henry Ford Health, Wayne State University and Michigan State University, Detroit, MI., Ambady P; Oregon Health and Science University, Portland, OR., Bota DA; University of California, Irvine, CA., Campen CJ; Stanford/Lucile Packard Children's Hospital and Stanford Children's Health, Palo Alto, CA., Kaur G; New York Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY., Klesse LJ; University of Texas Southwestern/Children's Health, Dallas, TX., Maraka S; University of Illinois at Chicago, Chicago, IL., Moots PL; Vanderbilt University Medical Center/Vanderbilt-Ingram Cancer Center, Nashville, TN., Nevel K; Indiana University Health/Indiana University School of Medicine, Indianapolis, IL., Bornhorst M; Children's National Hospital, Washington, DC., Aguilar-Bonilla A; Orlando Health, Inc, Orlando, FL., Chagnon S; Children's Hospital of the Kings Daughters, Norfolk, VA., Dalvi N; Montefiore Medical Center/Children's Hospital at Montefiore, New York City, NY., Gupta P; St Joseph's Regional Medical Center, Paterson, NJ., Khatib Z; Nicklaus Children's Hospital, Miami, FL., Metrock LK; University of Alabama at Birmingham, Birmingham, AL., Nghiemphu PL; University of California, Los Angeles (UCLA), Los Angeles, CA., Roberts RD; Nationwide Children's Hospital, Columbus, OH., Robison NJ; Children's Hospital Los Angeles, Los Angeles, CA., Sadighi Z; University of Texas MD Anderson Cancer Center, Houston, TX., Stapleton S; Johns Hopkins All Children's Hospital, St Petersburg, FL., Babovic-Vuksanovic D; Mayo Clinic, Rochester, MN., Gershon TR; Department of Pediatrics, Emory University, Atlanta, GA.
Corporate Authors: ReNeu Trial Investigators, ReNeu Study Investigators
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2025 Feb 20; Vol. 43 (6), pp. 716-729. Date of Electronic Publication: 2024 Nov 08.
Publication Type: Journal Article; Clinical Trial, Phase II; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-7755 (Electronic) Linking ISSN: 0732183X NLM ISO Abbreviation: J Clin Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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  Data: <searchLink fieldCode="AU" term="%22Moertel+CL%22">Moertel CL</searchLink>; Department of Pediatrics, University of Minnesota, Minneapolis, MN.<br /><searchLink fieldCode="AU" term="%22Hirbe+AC%22">Hirbe AC</searchLink>; Washington University School of Medicine in St Louis, St Louis, MO.<br /><searchLink fieldCode="AU" term="%22Shuhaiber+HH%22">Shuhaiber HH</searchLink>; University of Florida Clinical Research Center, Gainesville, FL.<br /><searchLink fieldCode="AU" term="%22Bielamowicz+K%22">Bielamowicz K</searchLink>; The University of Arkansas for Medical Sciences/Arkansas Children's Hospital, Little Rock, AR.<br /><searchLink fieldCode="AU" term="%22Sidhu+A%22">Sidhu A</searchLink>; University of Iowa Hospitals and Clinics, Iowa City, IA.<br /><searchLink fieldCode="AU" term="%22Viskochil+D%22">Viskochil D</searchLink>; University of Utah, Salt Lake City, UT.<br /><searchLink fieldCode="AU" term="%22Weber+MD%22">Weber MD</searchLink>; SpringWorks Therapeutics, Inc, Stamford, CT.<br /><searchLink fieldCode="AU" term="%22Lokku+A%22">Lokku A</searchLink>; SpringWorks Therapeutics, Inc, Stamford, CT.<br /><searchLink fieldCode="AU" term="%22Smith+LM%22">Smith LM</searchLink>; SpringWorks Therapeutics, Inc, Stamford, CT.<br /><searchLink fieldCode="AU" term="%22Foreman+NK%22">Foreman NK</searchLink>; Children's Hospital Colorado, Aurora, CO.<br /><searchLink fieldCode="AU" term="%22Hajjar+FM%22">Hajjar FM</searchLink>; AdventHealth for Children, Orlando, FL.<br /><searchLink fieldCode="AU" term="%22McNall-Knapp+RY%22">McNall-Knapp RY</searchLink>; University of Oklahoma Health Sciences Center, Oklahoma City, OK.<br /><searchLink fieldCode="AU" term="%22Weintraub+L%22">Weintraub L</searchLink>; Albany Medical Center, Albany, NY.<br /><searchLink fieldCode="AU" term="%22Antony+R%22">Antony R</searchLink>; University of California Davis, Sacramento, CA.<br /><searchLink fieldCode="AU" term="%22Franson+AT%22">Franson AT</searchLink>; University of Michigan, Ann Arbor, MI.<br /><searchLink fieldCode="AU" term="%22Meade+J%22">Meade J</searchLink>; University of Pittsburgh School of Medicine, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Schiff+D%22">Schiff D</searchLink>; University of Virginia Medical Center, Charlottesville, VA.<br /><searchLink fieldCode="AU" term="%22Walbert+T%22">Walbert T</searchLink>; Henry Ford Health, Wayne State University and Michigan State University, Detroit, MI.<br /><searchLink fieldCode="AU" term="%22Ambady+P%22">Ambady P</searchLink>; Oregon Health and Science University, Portland, OR.<br /><searchLink fieldCode="AU" term="%22Bota+DA%22">Bota DA</searchLink>; University of California, Irvine, CA.<br /><searchLink fieldCode="AU" term="%22Campen+CJ%22">Campen CJ</searchLink>; Stanford/Lucile Packard Children's Hospital and Stanford Children's Health, Palo Alto, CA.<br /><searchLink fieldCode="AU" term="%22Kaur+G%22">Kaur G</searchLink>; New York Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Klesse+LJ%22">Klesse LJ</searchLink>; University of Texas Southwestern/Children's Health, Dallas, TX.<br /><searchLink fieldCode="AU" term="%22Maraka+S%22">Maraka S</searchLink>; University of Illinois at Chicago, Chicago, IL.<br /><searchLink fieldCode="AU" term="%22Moots+PL%22">Moots PL</searchLink>; Vanderbilt University Medical Center/Vanderbilt-Ingram Cancer Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Nevel+K%22">Nevel K</searchLink>; Indiana University Health/Indiana University School of Medicine, Indianapolis, IL.<br /><searchLink fieldCode="AU" term="%22Bornhorst+M%22">Bornhorst M</searchLink>; Children's National Hospital, Washington, DC.<br /><searchLink fieldCode="AU" term="%22Aguilar-Bonilla+A%22">Aguilar-Bonilla A</searchLink>; Orlando Health, Inc, Orlando, FL.<br /><searchLink fieldCode="AU" term="%22Chagnon+S%22">Chagnon S</searchLink>; Children's Hospital of the Kings Daughters, Norfolk, VA.<br /><searchLink fieldCode="AU" term="%22Dalvi+N%22">Dalvi N</searchLink>; Montefiore Medical Center/Children's Hospital at Montefiore, New York City, NY.<br /><searchLink fieldCode="AU" term="%22Gupta+P%22">Gupta P</searchLink>; St Joseph's Regional Medical Center, Paterson, NJ.<br /><searchLink fieldCode="AU" term="%22Khatib+Z%22">Khatib Z</searchLink>; Nicklaus Children's Hospital, Miami, FL.<br /><searchLink fieldCode="AU" term="%22Metrock+LK%22">Metrock LK</searchLink>; University of Alabama at Birmingham, Birmingham, AL.<br /><searchLink fieldCode="AU" term="%22Nghiemphu+PL%22">Nghiemphu PL</searchLink>; University of California, Los Angeles (UCLA), Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Roberts+RD%22">Roberts RD</searchLink>; Nationwide Children's Hospital, Columbus, OH.<br /><searchLink fieldCode="AU" term="%22Robison+NJ%22">Robison NJ</searchLink>; Children's Hospital Los Angeles, Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Sadighi+Z%22">Sadighi Z</searchLink>; University of Texas MD Anderson Cancer Center, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Stapleton+S%22">Stapleton S</searchLink>; Johns Hopkins All Children's Hospital, St Petersburg, FL.<br /><searchLink fieldCode="AU" term="%22Babovic-Vuksanovic+D%22">Babovic-Vuksanovic D</searchLink>; Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Gershon+TR%22">Gershon TR</searchLink>; Department of Pediatrics, Emory University, Atlanta, GA.
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  Data: <searchLink fieldCode="CA" term="%22ReNeu+Trial+Investigators%22">ReNeu Trial Investigators</searchLink><br /><searchLink fieldCode="CA" term="%22ReNeu+Study+Investigators%22">ReNeu Study Investigators</searchLink>
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  Data: <searchLink fieldCode="JN" term="%228309333%22">Journal of clinical oncology : official journal of the American Society of Clinical Oncology</searchLink> [J Clin Oncol] 2025 Feb 20; Vol. 43 (6), pp. 716-729. <i>Date of Electronic Publication: </i>2024 Nov 08.
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