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The impact of inactivation of the GH/IGF axis during aging on healthspan.

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Title: The impact of inactivation of the GH/IGF axis during aging on healthspan.
Authors: Poudel SB; David B. Kriser Dental Center, Department of Molecular Pathobiology, New York University College of Dentistry, 345 East 24Th Street, New York, NY, 10010-4086, USA., Ruff RR; David B. Kriser Dental Center, Department of Epidemiology and Health Promotion, New York University College of Dentistry, New York, NY, 10010-4086, USA., He Z; David B. Kriser Dental Center, Department of Molecular Pathobiology, New York University College of Dentistry, 345 East 24Th Street, New York, NY, 10010-4086, USA., Dixit M; David B. Kriser Dental Center, Department of Molecular Pathobiology, New York University College of Dentistry, 345 East 24Th Street, New York, NY, 10010-4086, USA., Yildirim G; David B. Kriser Dental Center, Department of Molecular Pathobiology, New York University College of Dentistry, 345 East 24Th Street, New York, NY, 10010-4086, USA., Jayarathne H; Department of Biological Sciences, iBio (Integrative Biosciences Center), Integrative Biosciences Center, and Institute of Environmental Health Sciences, Wayne State University, Detroit, MI, 48202, USA., Manchanayake DH; Department of Biological Sciences, iBio (Integrative Biosciences Center), Integrative Biosciences Center, and Institute of Environmental Health Sciences, Wayne State University, Detroit, MI, 48202, USA., Basta-Pljakic J; Department of Biomedical Engineering, City College of New York, New York, NY, 10031, USA., Duran-Ortiz S; Edison Biotechnology Institute and Department of Biomedical Sciences, Ohio University, Athens, OH, USA., Schaffler MB; Department of Biomedical Engineering, City College of New York, New York, NY, 10031, USA., Kopchick JJ; Edison Biotechnology Institute and Department of Biomedical Sciences, Ohio University, Athens, OH, USA., Sadagurski M; Department of Biological Sciences, iBio (Integrative Biosciences Center), Integrative Biosciences Center, and Institute of Environmental Health Sciences, Wayne State University, Detroit, MI, 48202, USA., Yakar S; David B. Kriser Dental Center, Department of Molecular Pathobiology, New York University College of Dentistry, 345 East 24Th Street, New York, NY, 10010-4086, USA. sy1007@nyu.edu.
Source: GeroScience [Geroscience] 2025 Jun; Vol. 47 (3), pp. 3027-3042. Date of Electronic Publication: 2024 Nov 13.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Poudel+SB%22">Poudel SB</searchLink>; David B. Kriser Dental Center, Department of Molecular Pathobiology, New York University College of Dentistry, 345 East 24Th Street, New York, NY, 10010-4086, USA.<br /><searchLink fieldCode="AU" term="%22Ruff+RR%22">Ruff RR</searchLink>; David B. Kriser Dental Center, Department of Epidemiology and Health Promotion, New York University College of Dentistry, New York, NY, 10010-4086, USA.<br /><searchLink fieldCode="AU" term="%22He+Z%22">He Z</searchLink>; David B. Kriser Dental Center, Department of Molecular Pathobiology, New York University College of Dentistry, 345 East 24Th Street, New York, NY, 10010-4086, USA.<br /><searchLink fieldCode="AU" term="%22Dixit+M%22">Dixit M</searchLink>; David B. Kriser Dental Center, Department of Molecular Pathobiology, New York University College of Dentistry, 345 East 24Th Street, New York, NY, 10010-4086, USA.<br /><searchLink fieldCode="AU" term="%22Yildirim+G%22">Yildirim G</searchLink>; David B. Kriser Dental Center, Department of Molecular Pathobiology, New York University College of Dentistry, 345 East 24Th Street, New York, NY, 10010-4086, USA.<br /><searchLink fieldCode="AU" term="%22Jayarathne+H%22">Jayarathne H</searchLink>; Department of Biological Sciences, iBio (Integrative Biosciences Center), Integrative Biosciences Center, and Institute of Environmental Health Sciences, Wayne State University, Detroit, MI, 48202, USA.<br /><searchLink fieldCode="AU" term="%22Manchanayake+DH%22">Manchanayake DH</searchLink>; Department of Biological Sciences, iBio (Integrative Biosciences Center), Integrative Biosciences Center, and Institute of Environmental Health Sciences, Wayne State University, Detroit, MI, 48202, USA.<br /><searchLink fieldCode="AU" term="%22Basta-Pljakic+J%22">Basta-Pljakic J</searchLink>; Department of Biomedical Engineering, City College of New York, New York, NY, 10031, USA.<br /><searchLink fieldCode="AU" term="%22Duran-Ortiz+S%22">Duran-Ortiz S</searchLink>; Edison Biotechnology Institute and Department of Biomedical Sciences, Ohio University, Athens, OH, USA.<br /><searchLink fieldCode="AU" term="%22Schaffler+MB%22">Schaffler MB</searchLink>; Department of Biomedical Engineering, City College of New York, New York, NY, 10031, USA.<br /><searchLink fieldCode="AU" term="%22Kopchick+JJ%22">Kopchick JJ</searchLink>; Edison Biotechnology Institute and Department of Biomedical Sciences, Ohio University, Athens, OH, USA.<br /><searchLink fieldCode="AU" term="%22Sadagurski+M%22">Sadagurski M</searchLink>; Department of Biological Sciences, iBio (Integrative Biosciences Center), Integrative Biosciences Center, and Institute of Environmental Health Sciences, Wayne State University, Detroit, MI, 48202, USA.<br /><searchLink fieldCode="AU" term="%22Yakar+S%22">Yakar S</searchLink>; David B. Kriser Dental Center, Department of Molecular Pathobiology, New York University College of Dentistry, 345 East 24Th Street, New York, NY, 10010-4086, USA. sy1007@nyu.edu.
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