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Genipin rescues developmental and degenerative defects in familial dysautonomia models and accelerates axon regeneration.

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Title: Genipin rescues developmental and degenerative defects in familial dysautonomia models and accelerates axon regeneration.
Authors: Saito-Diaz K; Center for Molecular Medicine, University of Georgia, Athens, GA 30602, USA., Dietrich P; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA., Saini T; Center for Molecular Medicine, University of Georgia, Athens, GA 30602, USA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA., Rashid MM; Regenerative Bioscience Center, Department of Animal and Dairy Science, College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA 30602, USA., Wu HF; Center for Molecular Medicine, University of Georgia, Athens, GA 30602, USA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA., Ishan M; Regenerative Bioscience Center, Department of Animal and Dairy Science, College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA 30602, USA., Sun X; College of Engineering, University of Georgia, Athens, GA 30602, USA., Bedillion S; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA., Patel AJ; Center for Molecular Medicine, University of Georgia, Athens, GA 30602, USA., Prudden AR; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.; Department of Chemistry, University of Georgia, Athens, GA 30602, USA., Wzientek CG; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.; Department of Chemistry, University of Georgia, Athens, GA 30602, USA., Knight TN; Center for Molecular Medicine, University of Georgia, Athens, GA 30602, USA., Chen YW; Department of Otolaryngology, Department of Cell, Developmental, and Regenerative Biology, Institute for Airway Sciences, Institute for Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Boons GJ; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.; Department of Chemistry, University of Georgia, Athens, GA 30602, USA.; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, and Bijvoet Center for Biomolecular Research, Utrecht University, 3508 TC Utrecht, Netherlands., Chen S; Department of Surgery and Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA.; Center for Stem Cell Biology, Sloan Kettering Institute, New York, NY 10065, USA., Studer L; Center for Stem Cell Biology, Sloan Kettering Institute, New York, NY 10065, USA.; Department of Developmental Biology, Sloan Kettering Institute, New York, NY 10065, USA., Tiemeyer M; Center for Molecular Medicine, University of Georgia, Athens, GA 30602, USA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA., Xu B; College of Engineering, University of Georgia, Athens, GA 30602, USA., Dragatsis I; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA., Liu HX; Regenerative Bioscience Center, Department of Animal and Dairy Science, College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA 30602, USA., Zeltner N; Center for Molecular Medicine, University of Georgia, Athens, GA 30602, USA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.; Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA.
Source: Science translational medicine [Sci Transl Med] 2024 Nov 20; Vol. 16 (774), pp. eadq2418. Date of Electronic Publication: 2024 Nov 20.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: Genipin rescues developmental and degenerative defects in familial dysautonomia models and accelerates axon regeneration.
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  Data: <searchLink fieldCode="AU" term="%22Saito-Diaz+K%22">Saito-Diaz K</searchLink>; Center for Molecular Medicine, University of Georgia, Athens, GA 30602, USA.<br /><searchLink fieldCode="AU" term="%22Dietrich+P%22">Dietrich P</searchLink>; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.<br /><searchLink fieldCode="AU" term="%22Saini+T%22">Saini T</searchLink>; Center for Molecular Medicine, University of Georgia, Athens, GA 30602, USA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.<br /><searchLink fieldCode="AU" term="%22Rashid+MM%22">Rashid MM</searchLink>; Regenerative Bioscience Center, Department of Animal and Dairy Science, College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA 30602, USA.<br /><searchLink fieldCode="AU" term="%22Wu+HF%22">Wu HF</searchLink>; Center for Molecular Medicine, University of Georgia, Athens, GA 30602, USA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.<br /><searchLink fieldCode="AU" term="%22Ishan+M%22">Ishan M</searchLink>; Regenerative Bioscience Center, Department of Animal and Dairy Science, College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA 30602, USA.<br /><searchLink fieldCode="AU" term="%22Sun+X%22">Sun X</searchLink>; College of Engineering, University of Georgia, Athens, GA 30602, USA.<br /><searchLink fieldCode="AU" term="%22Bedillion+S%22">Bedillion S</searchLink>; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.<br /><searchLink fieldCode="AU" term="%22Patel+AJ%22">Patel AJ</searchLink>; Center for Molecular Medicine, University of Georgia, Athens, GA 30602, USA.<br /><searchLink fieldCode="AU" term="%22Prudden+AR%22">Prudden AR</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.; Department of Chemistry, University of Georgia, Athens, GA 30602, USA.<br /><searchLink fieldCode="AU" term="%22Wzientek+CG%22">Wzientek CG</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.; Department of Chemistry, University of Georgia, Athens, GA 30602, USA.<br /><searchLink fieldCode="AU" term="%22Knight+TN%22">Knight TN</searchLink>; Center for Molecular Medicine, University of Georgia, Athens, GA 30602, USA.<br /><searchLink fieldCode="AU" term="%22Chen+YW%22">Chen YW</searchLink>; Department of Otolaryngology, Department of Cell, Developmental, and Regenerative Biology, Institute for Airway Sciences, Institute for Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Boons+GJ%22">Boons GJ</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.; Department of Chemistry, University of Georgia, Athens, GA 30602, USA.; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, and Bijvoet Center for Biomolecular Research, Utrecht University, 3508 TC Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; Department of Surgery and Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA.; Center for Stem Cell Biology, Sloan Kettering Institute, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Studer+L%22">Studer L</searchLink>; Center for Stem Cell Biology, Sloan Kettering Institute, New York, NY 10065, USA.; Department of Developmental Biology, Sloan Kettering Institute, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Tiemeyer+M%22">Tiemeyer M</searchLink>; Center for Molecular Medicine, University of Georgia, Athens, GA 30602, USA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.<br /><searchLink fieldCode="AU" term="%22Xu+B%22">Xu B</searchLink>; College of Engineering, University of Georgia, Athens, GA 30602, USA.<br /><searchLink fieldCode="AU" term="%22Dragatsis+I%22">Dragatsis I</searchLink>; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.<br /><searchLink fieldCode="AU" term="%22Liu+HX%22">Liu HX</searchLink>; Regenerative Bioscience Center, Department of Animal and Dairy Science, College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA 30602, USA.<br /><searchLink fieldCode="AU" term="%22Zeltner+N%22">Zeltner N</searchLink>; Center for Molecular Medicine, University of Georgia, Athens, GA 30602, USA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.; Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2024 Nov 20; Vol. 16 (774), pp. eadq2418. <i>Date of Electronic Publication: </i>2024 Nov 20.
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