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Neuronal and oligodendroglial, but not astroglial, tau translates to in vivo tau PET signals in individuals with primary tauopathies.

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Title: Neuronal and oligodendroglial, but not astroglial, tau translates to in vivo tau PET signals in individuals with primary tauopathies.
Authors: Slemann L; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany., Gnörich J; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany., Hummel S; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany., Bartos LM; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany., Klaus C; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany., Kling A; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany., Kusche-Palenga J; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany., Kunte ST; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany., Kunze LH; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany., Englert AL; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany., Li Y; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany., Vogler L; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany., Katzdobler S; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Department of Neurology, LMU Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Palleis C; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Department of Neurology, LMU Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Bernhardt A; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Department of Neurology, LMU Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Jäck A; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Department of Neurology, LMU Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Zwergal A; Department of Neurology, LMU Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; German Center for Vertigo and Balance Disorders, DSGZ, LMU Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Hopfner F; Department of Neurology, LMU Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Roemer-Cassiano SN; Department of Neurology, LMU Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Institute for Stroke and Dementia Research, LMU Hospital, LMU Munich, Munich, Germany., Biechele G; Department of Radiology, LMU Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Stöcklein S; Department of Radiology, LMU Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Bischof G; Cognitive Neuroscience, Institute for Neuroscience and Medicine (INM-3), Research Centre Juelich, Juelich, Germany.; Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany., van Eimeren T; Cognitive Neuroscience, Institute for Neuroscience and Medicine (INM-3), Research Centre Juelich, Juelich, Germany.; Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany.; Department of Neurology, University Hospital Cologne, Cologne, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Drzezga A; Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Sabri O; Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany., Barthel H; Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany., Respondek G; Department of Neurology, Medizinische Hochschule Hannover, Hannover, Germany., Grimmer T; Center for Cognitive Disorders, Department of Psychiatry and Psychotherapy, School of Medicine and Health, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany., Levin J; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Department of Neurology, LMU Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Herms J; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Center of Neuropathology and Prion Research, Faculty of Medicine, LMU Munich, Munich, Germany., Paeger L; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany., Willroider M; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany., Beyer L; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany., Höglinger GU; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Department of Neurology, LMU Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Roeber S; Center of Neuropathology and Prion Research, Faculty of Medicine, LMU Munich, Munich, Germany., Franzmeier N; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Institute for Stroke and Dementia Research, LMU Hospital, LMU Munich, Munich, Germany.; Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, , University of Gothenburg, The Sahlgrenska Academy, Mölndal, Gothenburg, Sweden., Brendel M; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany. matthias.brendel@med.uni-muenchen.de.; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany. matthias.brendel@med.uni-muenchen.de.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. matthias.brendel@med.uni-muenchen.de.
Source: Acta neuropathologica [Acta Neuropathol] 2024 Nov 24; Vol. 148 (1), pp. 70. Date of Electronic Publication: 2024 Nov 24.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Neuronal and oligodendroglial, but not astroglial, tau translates to in vivo tau PET signals in individuals with primary tauopathies.
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  Data: <searchLink fieldCode="AU" term="%22Slemann+L%22">Slemann L</searchLink>; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Gnörich+J%22">Gnörich J</searchLink>; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Hummel+S%22">Hummel S</searchLink>; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Bartos+LM%22">Bartos LM</searchLink>; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Klaus+C%22">Klaus C</searchLink>; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kling+A%22">Kling A</searchLink>; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kusche-Palenga+J%22">Kusche-Palenga J</searchLink>; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kunte+ST%22">Kunte ST</searchLink>; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kunze+LH%22">Kunze LH</searchLink>; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Englert+AL%22">Englert AL</searchLink>; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Vogler+L%22">Vogler L</searchLink>; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Katzdobler+S%22">Katzdobler S</searchLink>; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Department of Neurology, LMU Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Palleis+C%22">Palleis C</searchLink>; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Department of Neurology, LMU Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Bernhardt+A%22">Bernhardt A</searchLink>; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Department of Neurology, LMU Hospital, Ludwig Maximilian University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Jäck+A%22">Jäck A</searchLink>; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Department of Neurology, LMU Hospital, Ludwig Maximilian University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Zwergal+A%22">Zwergal A</searchLink>; Department of Neurology, LMU Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; German Center for Vertigo and Balance Disorders, DSGZ, LMU Hospital, Ludwig Maximilian University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Hopfner+F%22">Hopfner F</searchLink>; Department of Neurology, LMU Hospital, Ludwig Maximilian University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Roemer-Cassiano+SN%22">Roemer-Cassiano SN</searchLink>; Department of Neurology, LMU Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Institute for Stroke and Dementia Research, LMU Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Biechele+G%22">Biechele G</searchLink>; Department of Radiology, LMU Hospital, Ludwig Maximilian University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Stöcklein+S%22">Stöcklein S</searchLink>; Department of Radiology, LMU Hospital, Ludwig Maximilian University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Bischof+G%22">Bischof G</searchLink>; Cognitive Neuroscience, Institute for Neuroscience and Medicine (INM-3), Research Centre Juelich, Juelich, Germany.; Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22van+Eimeren+T%22">van Eimeren T</searchLink>; Cognitive Neuroscience, Institute for Neuroscience and Medicine (INM-3), Research Centre Juelich, Juelich, Germany.; Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany.; Department of Neurology, University Hospital Cologne, Cologne, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Drzezga+A%22">Drzezga A</searchLink>; Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Sabri+O%22">Sabri O</searchLink>; Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Barthel+H%22">Barthel H</searchLink>; Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Respondek+G%22">Respondek G</searchLink>; Department of Neurology, Medizinische Hochschule Hannover, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Grimmer+T%22">Grimmer T</searchLink>; Center for Cognitive Disorders, Department of Psychiatry and Psychotherapy, School of Medicine and Health, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Levin+J%22">Levin J</searchLink>; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Department of Neurology, LMU Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Herms+J%22">Herms J</searchLink>; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Center of Neuropathology and Prion Research, Faculty of Medicine, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Paeger+L%22">Paeger L</searchLink>; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Willroider+M%22">Willroider M</searchLink>; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Beyer+L%22">Beyer L</searchLink>; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Höglinger+GU%22">Höglinger GU</searchLink>; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Department of Neurology, LMU Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Roeber+S%22">Roeber S</searchLink>; Center of Neuropathology and Prion Research, Faculty of Medicine, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Franzmeier+N%22">Franzmeier N</searchLink>; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Institute for Stroke and Dementia Research, LMU Hospital, LMU Munich, Munich, Germany.; Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, , University of Gothenburg, The Sahlgrenska Academy, Mölndal, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Brendel+M%22">Brendel M</searchLink>; Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Marchioninstraße 15, 81377, Munich, Germany. matthias.brendel@med.uni-muenchen.de.; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany. matthias.brendel@med.uni-muenchen.de.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. matthias.brendel@med.uni-muenchen.de.
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