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EZH2 directly methylates PARP1 and regulates its activity in cancer.

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Title: EZH2 directly methylates PARP1 and regulates its activity in cancer.
Authors: Meng Q; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA., Shen J; Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405, USA., Ren Y; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Liu Q; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Wang R; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Li Q; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Jiang W; Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA., Wang Q; Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405, USA., Zhang Y; Department of Chemistry, Biological Mass Spectrometry Facility, Indiana University, Bloomington, IN 47405, USA.; Research Technology Branch, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA., Trinidad JC; Department of Chemistry, Biological Mass Spectrometry Facility, Indiana University, Bloomington, IN 47405, USA., Lu X; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN 55455, USA., Wang T; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Li Y; Basic and Translational Research Division, Department of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Yum C; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Yi Y; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA., Yang Y; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Zhao D; Basic and Translational Research Division, Department of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Harris C; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA., Kalantry S; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA., Chen K; Basic and Translational Research Division, Department of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Yang R; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Niu H; Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405, USA., Cao Q; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Source: Science advances [Sci Adv] 2024 Nov 29; Vol. 10 (48), pp. eadl2804. Date of Electronic Publication: 2024 Nov 27.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: EZH2 directly methylates PARP1 and regulates its activity in cancer.
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  Data: <searchLink fieldCode="AU" term="%22Meng+Q%22">Meng Q</searchLink>; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Shen+J%22">Shen J</searchLink>; Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405, USA.<br /><searchLink fieldCode="AU" term="%22Ren+Y%22">Ren Y</searchLink>; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Q%22">Liu Q</searchLink>; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Wang+R%22">Wang R</searchLink>; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+W%22">Jiang W</searchLink>; Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Chemistry, Biological Mass Spectrometry Facility, Indiana University, Bloomington, IN 47405, USA.; Research Technology Branch, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA.<br /><searchLink fieldCode="AU" term="%22Trinidad+JC%22">Trinidad JC</searchLink>; Department of Chemistry, Biological Mass Spectrometry Facility, Indiana University, Bloomington, IN 47405, USA.<br /><searchLink fieldCode="AU" term="%22Lu+X%22">Lu X</searchLink>; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN 55455, USA.<br /><searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink>; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Basic and Translational Research Division, Department of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Yum+C%22">Yum C</searchLink>; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Yi+Y%22">Yi Y</searchLink>; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+D%22">Zhao D</searchLink>; Basic and Translational Research Division, Department of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Harris+C%22">Harris C</searchLink>; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Kalantry+S%22">Kalantry S</searchLink>; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Chen+K%22">Chen K</searchLink>; Basic and Translational Research Division, Department of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Yang+R%22">Yang R</searchLink>; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Niu+H%22">Niu H</searchLink>; Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405, USA.<br /><searchLink fieldCode="AU" term="%22Cao+Q%22">Cao Q</searchLink>; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
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