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Enzymatic, structural, and biophysical characterization of a single-domain antibody (VHH) selectively and tightly inhibiting neutrophil elastase and exhibiting favorable developability properties.

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Title: Enzymatic, structural, and biophysical characterization of a single-domain antibody (VHH) selectively and tightly inhibiting neutrophil elastase and exhibiting favorable developability properties.
Authors: Redeghieri P; Nano-Antibodies to Explore Protein Structure and Functions (NEPTUNS), Centre for Protein Engineering, InBios, Department of Life Sciences, University of Liège, Liège, Belgium., Moray J; Nano-Antibodies to Explore Protein Structure and Functions (NEPTUNS), Centre for Protein Engineering, InBios, Department of Life Sciences, University of Liège, Liège, Belgium., Kerff F; Biological Macromolecule Crystallography, Centre for Protein Engineering, InBios, Department of Life Sciences, University of Liège, Liège, Belgium., Gohy S; Department of Pneumology, ENT and Dermatology, Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain, Brussels, Belgium.; Cystic Fibrosis Reference Centre, Cliniques Universitaires Saint-Luc, Brussels, Belgium., Leal T; Louvain Center for Toxicology and Applied Pharmacology (LTAP), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain, Brussels, Belgium., Muyldermans S; Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium., Vanbever R; Louvain Drug Research Institute (LDRI), Université Catholique de Louvain, Brussels, Belgium., Morales-Yánez FJ; Nano-Antibodies to Explore Protein Structure and Functions (NEPTUNS), Centre for Protein Engineering, InBios, Department of Life Sciences, University of Liège, Liège, Belgium., Dumoulin M; Nano-Antibodies to Explore Protein Structure and Functions (NEPTUNS), Centre for Protein Engineering, InBios, Department of Life Sciences, University of Liège, Liège, Belgium.
Source: Protein science : a publication of the Protein Society [Protein Sci] 2024 Dec; Vol. 33 (12), pp. e5227.
Publication Type: Journal Article
Journal Info: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Enzymatic, structural, and biophysical characterization of a single-domain antibody (VHH) selectively and tightly inhibiting neutrophil elastase and exhibiting favorable developability properties.
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  Data: <searchLink fieldCode="AU" term="%22Redeghieri+P%22">Redeghieri P</searchLink>; Nano-Antibodies to Explore Protein Structure and Functions (NEPTUNS), Centre for Protein Engineering, InBios, Department of Life Sciences, University of Liège, Liège, Belgium.<br /><searchLink fieldCode="AU" term="%22Moray+J%22">Moray J</searchLink>; Nano-Antibodies to Explore Protein Structure and Functions (NEPTUNS), Centre for Protein Engineering, InBios, Department of Life Sciences, University of Liège, Liège, Belgium.<br /><searchLink fieldCode="AU" term="%22Kerff+F%22">Kerff F</searchLink>; Biological Macromolecule Crystallography, Centre for Protein Engineering, InBios, Department of Life Sciences, University of Liège, Liège, Belgium.<br /><searchLink fieldCode="AU" term="%22Gohy+S%22">Gohy S</searchLink>; Department of Pneumology, ENT and Dermatology, Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain, Brussels, Belgium.; Cystic Fibrosis Reference Centre, Cliniques Universitaires Saint-Luc, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Leal+T%22">Leal T</searchLink>; Louvain Center for Toxicology and Applied Pharmacology (LTAP), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Muyldermans+S%22">Muyldermans S</searchLink>; Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Vanbever+R%22">Vanbever R</searchLink>; Louvain Drug Research Institute (LDRI), Université Catholique de Louvain, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Morales-Yánez+FJ%22">Morales-Yánez FJ</searchLink>; Nano-Antibodies to Explore Protein Structure and Functions (NEPTUNS), Centre for Protein Engineering, InBios, Department of Life Sciences, University of Liège, Liège, Belgium.<br /><searchLink fieldCode="AU" term="%22Dumoulin+M%22">Dumoulin M</searchLink>; Nano-Antibodies to Explore Protein Structure and Functions (NEPTUNS), Centre for Protein Engineering, InBios, Department of Life Sciences, University of Liège, Liège, Belgium.
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              Text: 2024 Dec
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