Spatially resolved gene expression profiling of tumor microenvironment reveals key steps of lung adenocarcinoma development.

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Title: Spatially resolved gene expression profiling of tumor microenvironment reveals key steps of lung adenocarcinoma development.
Authors: Takano Y; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan.; Pharmaceutical Science Department, Chugai Pharmaceutical Co., Ltd., Chuo-ku, Tokyo, Japan., Suzuki J; Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.; Department of General Thoracic Surgery, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan., Nomura K; Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan., Fujii G; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan., Zenkoh J; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan., Kawai H; Department of Diagnostic Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Kuze Y; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan., Kashima Y; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan., Nagasawa S; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan., Nakamura Y; Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan., Kojima M; Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan., Tsuchihara K; Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan., Seki M; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan., Kanai A; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan., Matsubara D; Department of Diagnostic Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Kohno T; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Noguchi M; Department of Diagnostic Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.; Center for Clinical and Translational Science, Shonan Kamakura General Hospital, Kamakura, Kanagawa, Japan., Nakaya A; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan., Tsuboi M; Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan., Ishii G; Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan., Suzuki Y; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan. ysuzuki@edu.k.u-tokyo.ac.jp., Suzuki A; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan. asuzuki@edu.k.u-tokyo.ac.jp.
Source: Nature communications [Nat Commun] 2024 Dec 06; Vol. 15 (1), pp. 10637. Date of Electronic Publication: 2024 Dec 06.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-024-54671-7